Citation Impact
Citing Papers
Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
2014 Science
Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin
2013 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance
2018 Standout
Mutation of a Self-Processing Site in Caspase-8 Compromises Its Apoptotic but Not Its Nonapoptotic Functions in Bacterial Artificial Chromosome-Transgenic Mice
2008
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
IRF-7 is the master regulator of type-I interferon-dependent immune responses
2005 StandoutNature
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
2011 Nature
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
2011
Apoptosis in the nervous system
2000 StandoutNature
Inflammation and metabolic disorders
2006 StandoutNature
Necroptosis and its role in inflammation
2015 StandoutNature
Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis
2001
Impact of obesity on treatment of chronic hepatitis C†
2006
Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis
1999
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Caspase knockouts: matters of life and death
1999
Death by TNF: a road to inflammation
2022
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium–derived factor
2002 Standout
Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL
2001
The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
2011
IAP family proteins---suppressors of apoptosis
1999 Standout
Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis
2013
The Hallmarks of Cancer
2000 Standout
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
1999 Nature
Functional complementation between FADD and RIP1 in embryos and lymphocytes
2011 Nature
The biochemistry of apoptosis
2000 StandoutNature
RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
2011
Apoptotic mechanisms in the control of erythropoiesis
2004
Molecular and cellular mechanisms of liver fibrosis and its regression
2020
Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation
2002
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Cell Death in Development
1999
Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome
2012
Caspase Functions in Cell Death and Disease
2013 Standout
Caspase structure, proteolytic substrates, and function during apoptotic cell death
1999
Remodelling the extracellular matrix in development and disease
2014 Standout
A FADD-dependent innate immune mechanism in mammalian cells
2004 Nature
RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein
2011
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
2011 Nature
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Apoptosis control by death and decoy receptors
1999
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
2011
Apoptosis without caspases: an inefficient molecular guillotine?
1999
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
2014
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Necroptosis in development, inflammation and disease
2016
Dysregulation of apoptosis genes in hematopoietic malignancies
2002
Proteolytic networks in cancer
2011
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Signal transduction by tumor necrosis factor and its relatives
2001
Atherosclerosis
2000 StandoutNature
The role of BH3-only proteins in the immune system
2005
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
2006 Standout
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
2008 StandoutNature
Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
2012
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
A decade of caspases
2003
Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases
1999
Pathogen Recognition and Innate Immunity
2006 Standout
Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin
2014
The ced-8 Gene Controls the Timing of Programmed Cell Deaths in C. elegans
2000 StandoutNobel
Mechanisms of caspase activation
2003
Programmed Cell Death in Animal Development and Disease
2011
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Control of Life-or-Death Decisions by RIP1 Kinase
2013
Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions
2000
FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
2011
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
2000 StandoutScience
The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
1998
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal
2002
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Biochemical Pathways of Caspase Activation During Apoptosis
1999 Standout
FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis
2001
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
2002 StandoutNobel
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis
2013
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction
1999
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
The Incredible Life and Times of Biological Cells
2000 StandoutScienceNobel
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
2002 StandoutScience
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
2000
Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis
2003
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
2009
FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes
2014
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
2006 StandoutScience
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner
1999 Standout
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
2000
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Marcus Schuchmann being referenced
Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally
1998
Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis
2013
Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8
2013
Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo
2011
Functional discrepancies between tumor necrosis factor and lymphotoxin α explained by trimer stability and distinct receptor interactions
1995
CD40 induces resistance to TNF-mediated apoptosis in a fibroblast cell line
1998
The HEP-NET B/C co-infection trial: A prospective multicenter study to investigate the efficacy of pegylated interferon-α2b and ribavirin in patients with HBV/HCV co-infection
2008
Apoptosis in liver disease
2001
Role of caspase‐8 in hepatocyte response to infection and injury in mice†
2007
Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation
2017
Cutting Edge: A Key Pathogenic Role of IL-27 in T Cell- Mediated Hepatitis
2008
610 Anti IL-6 therapy rescues transgenic mice with liver specific overexpression of TGF-β1 from death after LPS mediated liver injury
2004