Standout Papers
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth (2011)
- FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex (1996)
- The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 (2008)
- Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. (1995)
Citation Impact
Citing Papers
MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents
2009
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
2003
Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment
2012
p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice
1998
Hallmarks of Cancer: The Next Generation
2011 Standout
Fas Ligand-independent, FADD-mediated Activation of the Fas Death Pathway by Anticancer Drugs
1999
Identification and Characterization of an IκB Kinase
1997
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
2015
RIP3, a Novel Apoptosis-inducing Kinase
1999
Involvement of Members of the Cadherin Superfamily in Cancer
2009
ICEBERG
2000
Efficient T Cell Activation via a Toll-Interleukin 1 Receptor-Independent Pathway
2006 StandoutNobel
Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA
1996
Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
1997 Nobel
Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells
1998
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
2009 Standout
Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α
1998
Target Protease Specificity of the Viral Serpin CrmA
1997
Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity
2006
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
2009 Standout
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
1998 Standout
Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis
2001
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer
2009
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
1996 Standout
Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo
1999 Standout
An Induced Proximity Model for Caspase-8 Activation
1998
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
Apoptotic Pathways
2000
Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
1998
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
2000
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB
1999 Standout
Granzyme B Induces BID-mediated Cytochrome c Release and Mitochondrial Permeability Transition
2001
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
2008 Standout
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Molecules involved in cell death and peripheral tolerance
1997
RAIDD is a new 'death' adaptor molecule
1997 Nature
Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL
1997
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
2012 Standout
Casper Is a FADD- and Caspase-Related Inducer of Apoptosis
1997
Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
2009
Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage
1998
NMR structure of the death domain of the p75 neurotrophin receptor
1997
Inhibition of Receptor Internalization by Monodansylcadaverine Selectively Blocks p55 Tumor Necrosis Factor Receptor Death Domain Signaling
1999
Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats
1999
Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
1998 Nature
Immunoelectron microscopic localization of the HPC-1 antigen in rat cerebellum
1993
Apoptosis by Death Factor
1997 Standout
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development
2000
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Origins of Metastatic Traits
2013
The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation
1993
Identification of a ligand for the death-domain-containing receptor Apo3
1998
X-linked IAP is a direct inhibitor of cell-death proteases
1997 StandoutNature
The Large Subunit of the DNA Replication Complex C (DSEB/RF-C140) Cleaved and Inactivated by Caspase-3 (CPP32/YAMA) during Fas-induced Apoptosis
1997
The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2
1999
TNF, Apoptosis and Autoimmunity: A Common Thread?
1998 StandoutNobel
IAP family proteins---suppressors of apoptosis
1999 Standout
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
2002
MicroRNAs as regulators of epithelial-mesenchymal transition
2008
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
2000 Standout
Cell Death
2004 Standout
Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments
1991 StandoutNobel
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
1999 Nature
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
1995 Standout
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
2010 Standout
Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors
1999
ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing
2009
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
2008 StandoutNature
Tumor metastasis: moving new biological insights into the clinic
2013
Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin
1990
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
2002
Cell Death in Pancreatitis
2005
Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8
2001
TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL
1997
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Caspase activity is required for commitment to Fas-mediated apoptosis
1997
A second higher vertebrate B-type lamin
1989
Cell Death in Development
1999
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 Standout
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation
2003
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
1998
Intrinsic tumour suppression
2004 Nature
Characterization of two receptors for TRAIL1
1997
Intermediate filaments: structure, assembly and molecular interactions
1990
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
2002 Nature
Widespread changes in protein synthesis induced by microRNAs
2008 StandoutNature
T cell life and death signalling via TNF-receptor family members
2000
TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)
1997
A License to Kill
1996
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Apoptosis
2002 Standout
IAP proteins: blocking the road to death's door
2002
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 Standout
Two CD95 (APO-1/Fas) signaling pathways
1998 Standout
I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis
1997
Proteases to die for
1998
Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish
2000
Targeting metastasis-initiating cells through the fatty acid receptor CD36
2016 Nature
Transducing signals of life and death
1997
Inhibition of Fas death signals by FLIPs
1998
TNF receptor associated factors in cytokine signaling
1999
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
1998 Standout
Characterization of seven murine caspase family members
1997
Refined structure of elongation factor EF-Tu from Escherichia coli
1992
Caspases: killer proteases
1997 Standout
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Substrates for p34cdc2: In vivo veritas?
1990 StandoutNobel
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
2009
Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells
2000
TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex
1996
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
1997 Standout
What We Talk About When We Talk About Fat
2014 Standout
Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation
2004
Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c
1998
Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis
1997
Elimination of Antigen-Presenting Cells and Autoreactive T Cells by Fas Contributes to Prevention of Autoimmunity
2007
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
2003 Standout
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
The basics of epithelial-mesenchymal transition
2009 Standout
Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB
1996
The cell-death machine
1996
Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?
1996
A Unified Model for Apical Caspase Activation
2003
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
2000 Standout
let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells
2007 Standout
Autophagy: process and function
2007 Standout
Biomarkers for epithelial-mesenchymal transitions
2009 Standout
Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II
1999
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
1997
Autoproteolytic Activation of Pro-Caspases by Oligomerization
1998 Nobel
FLICE Induced Apoptosis in a Cell-free System
1997
The TNF and TNF Receptor Superfamilies
2001 Standout
Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway
1997
RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis
1998
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase
1998
Autoimmunity and Apoptosis
2001 StandoutNobel
Inhibition of death receptor signals by cellular FLIP
1997 StandoutNature
TNF-Induced Signaling in Apoptosis
1999
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
2010 Standout
Calreticulin exposure dictates the immunogenicity of cancer cell death
2006 Standout
NF-κB at the crossroads of life and death
2002 Standout
Kaposi's Sarcoma
2000 Standout
Crystal structure of active elongation factor Tu reveals major domain rearrangements
1993 Nature
Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition
2008
Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
2006
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
1997
Regulation of death receptor signaling by the ubiquitin system
2009
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
1994 StandoutNatureNobel
CD95's deadly mission in the immune system
2000 Nature
Mechanisms and Implications of Metabolic Heterogeneity in Cancer
2019
Transcriptional regulation of cell polarity in EMT and cancer
2008
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Heat shock proteins – modulators of apoptosis in tumour cells
2000
Nucleotide sequence of theThermus thermophilus HB8gene coding for elongation factor G
1989
Apoptosis and the maintenance of homoeostasis in the immune system
1996
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
2000
Dysregulation of Apoptosis in Cancer
1999
The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2.
1991
Signaling by the TNF Receptor Superfamily and T Cell Homeostasis
2000
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
Premature p34 cdc2 Activation Required for Apoptosis
1994 Science
NF-κB Signals Induce the Expression of c-FLIP
2001
The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution.
1994 StandoutNobel
Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein
1999
Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway
1997 Science
The identification of a domain in Escherichia coli elongation factor Tu that interacts with elongation factor Ts.
1992
Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors
1997 StandoutScience
Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms
2002
Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells.
2000
Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor
1998
Fundamentals of cancer metabolism
2016 Standout
Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells
2000
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal
1998
Specific interactions of Mss4 with members of the Rab GTPase subfamily.
1994
Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus.
1994
Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex
2003
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
1998 StandoutScience
Death Receptors: Signaling and Modulation
1998 StandoutScience
Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis
1997
p34cdc2 acts as a lamin kinase in fission yeast.
1991 StandoutNobel
Caspase-10 is an initiator caspase in death receptor signaling
2001
FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis
2001
The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment
2007
Fas ligation induces apoptosis of CD40-activated human B lymphocytes.
1995
The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition
2008
The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase.
1992 StandoutNobel
Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif.
1989
Regulation of Fas-associated Death Domain Interactions by the Death Effector Domain Identified by a Modified Reverse Two-hybrid Screen
2002
Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
1996
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction
1999
Metabolic reprogramming and cancer progression
2020 StandoutScience
Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death
1997 Science
Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells
1997
FADD is required for multiple signaling events downstream of the receptor Fas.
1999
Bcl-X L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
1998
Caspase-independent Cell Killing by Fas-associated Protein with Death Domain
1998
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells
2008
A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.
1996
Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95
1996 Science
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
2010
The Receptor for the Cytotoxic Ligand TRAIL
1997 StandoutScience
BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases
1996
The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis
1997
A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
1997
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
Cellular stress response and apoptosis in cancer therapy
2001
Fas Ligand-Induced c-Jun Kinase Activation in Lymphoid Cells Requires Extensive Receptor Aggregation But Is Independent of DAXX, and Fas-Mediated Cell Death Does Not Involve DAXX, RIP, or RAIDD
2000
Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.
1995
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
1998
Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
1997
Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways
1998
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.
1996
Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis
1997 Standout
Modulation of Caspase-8 and FLICE-Inhibitory Protein Expression as a Potential Mechanism of Epstein-Barr Virus Tumorigenesis in Burkitt’s Lymphoma
1999
Bcl-xLcan inhibit apoptosis in cells that have undergone Fas-induced protease activation
1997
FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis
1998 Science
A somatic cell-derived system for studying both early and late mitotic events in vitro
1989
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.
1993
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
1996 StandoutScience
Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1.
1992
Works of Marcus E. Peter being referenced
APO‐1(CD95)‐mediated apoptosis in Jurkat cells does not involve src kinases or CD45
1995
Identification of Let-7–Regulated Oncofetal Genes
2008
Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube
2016
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
1997 Nature
Apoptosis signaling in lymphocytes
1999
Cloning and sequencing of cDNA clones encoding chicken lamins A and B1 and comparison of the primary structures of vertebrate A- and B-type lamins
1989
In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase
1990
Apoptosis signaling by death receptors
1998
S-Adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis
1996
The CD95(APO-1/Fas) DISC and beyond
2003
The Role of c-FLIP in Modulation of CD95-induced Apoptosis
1999
Bcl-xL Acts Downstream of Caspase-8 Activation by the CD95 Death-inducing Signaling Complex
1998
Resistance of cultured peripheral T cells towards activation‐induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death‐inducing signaling complex
1997
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
2005
The Role of APO‐1‐Mediated Apoptosis in the Immune System
1994
Interaction of the isolated domain II/III ofThermus thermophiluselongation factor Tu with the nucleotide exchange factor EF-Ts
1990
Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
1998
APO-1(CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines
1995
Mapping the effector region in Thermus thermophilus elongation factor Tu
1990
Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression
2009
Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells
1999
The Death Receptors
1999
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
2008 Standout
Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells
1998
The CD95 Type I/Type II model
2003
Affinity labeling of the GDP/GTP binding site in Thermus thermophilus elongation factor Tu
1988
AIDS and the death receptors
1997
Nonapoptotic functions of FADD-binding death receptors and their signaling molecules
2005
Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid
1998
Differential sialylation of cell surface glycoconjugates in a human B lymphoma cell line regulates susceptibility for CD95 (APO-1/Fas)-mediated apoptosis and for infection by a lymphotropic virus
1999
FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis
1996
Cleavage of FLICE (caspase‐8) by granzyme B during cytotoxic T lymphocyte‐induced apoptosis
1997
Local gene density predicts the spatial position of genetic loci in the interphase nucleus
2005
Sequence and identification of the nucleotide binding site for the elongation factor Tu fromThermus thermophilusHB8
1987
FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b
1997
Mapping small GTP‐binding proteins on high‐resolution two‐dimensional gels by a combination of GTP binding and labeling with in situ periodateoxidized GTP
1994
Expression of c-FLIPL and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide
2000
Phosphatidylinositol 3′-Kinase Blocks CD95 Aggregation and Caspase-8 Cleavage at the Death-Inducing Signaling Complex by Modulating Lateral Diffusion of CD95
2001
CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases.
1996
Immunological characterization of avian MAP kinases: evidence for nuclear localization.
1992
Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short).
2001
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
1995 Standout
Let-7 expression defines two differentiation stages of cancer
2007
CD95 (APO-1/Fas)-associating signalling proteins.
1996
Identification of the Cytolinker Plectin as a Major Early In Vivo Substrate for Caspase 8 during CD95- and Tumor Necrosis Factor Receptor-Mediated Apoptosis
2000
Expression of c-FLIPL and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide
2000
The flip side of FLIP
2004
Cell surface sialylation plays a role in modulating sensitivity towards APO-1-mediated apoptotic cell death.
1995
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
2011 Standout
Isoprenylation of rab proteins on structurally distinct cysteine motifs
1992
Advances in apoptosis research
1997
The TRAIL DISCussion: It is FADD and caspase-8!
2000
Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia
1999
Molecular Ordering of the Initial Signaling Events of CD95
2002
Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.
1994