Citation Impact
Citing Papers
Cells have distinct mechanisms to maintain protection against different reactive oxygen species: Oxidative-stress-response genes
2004
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
2009 Science
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Biochemistry of B Lymphocyte Activation
1993
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth
2011
Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant
1991
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Proteins regulating Ras and its relatives
1993 StandoutNature
Insulin Stimulates the Phosphorylation of the 66- and 52-Kilodalton Shc Isoforms by Distinct Pathways1
1997
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
1994
Activators and effectors of ras p21 proteins
1994
Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange
2001
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Characterization of a Cytochrome P450 from the Acidothermophilic ArchaeaSulfolobus solfataricus
1998
Oxidative stress and gene regulation
2000
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
Simple and Complex Cell Cycles
1989
Signal transduction in yeast
1994
Regulation of Mitochondrial Protein Import by Cytosolic Kinases
2011
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
2013 Nature
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
2009
GTP-Binding Proteins: Structures, interactions and relationships
1994
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
The Hallmarks of Cancer
2000 Standout
The GTPase superfamily: conserved structure and molecular mechanism
1991 StandoutNature
Phosphatidylinositol-3-OH kinase direct target of Ras
1994 StandoutNature
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
1992 Nature
Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast
1998 StandoutNobel
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Control of glutamine metabolism by the tumor suppressor Rb
2013
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Protein modules and signalling networks
1995 StandoutNature
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
A Novel GTPase-activating Protein for R-Ras
1995
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Cooperative interaction of S. pombe proteins required for mating and morphogenesis
1994
Clonal selection and learning in the antibody system
1996 StandoutNature
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
1993
Redox control of glutamine utilization in cancer
2014
The p66shc adaptor protein controls oxidative stress response and life span in mammals
1999 StandoutNature
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
2014
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
1998
A novel role for RhoGDI as an inhibitor of GAP proteins.
1993
A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.
1996
Clues from cell metabolism
2010 StandoutNatureNobel
The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.
1991
Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient
2011 StandoutNobel
The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane
2003 StandoutNobel
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
The role of p21ras in receptor tyrosine kinase signaling
1995
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins.
1993
Function of Ras as a molecular switch in signal transduction.
1992
Sequence–Structure–Binding Relationships Reveal Adhesion Behavior of the Car9 Solid-Binding Peptide: An Integrated Experimental and Simulation Study
2020 StandoutNobel
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
2012
Introducing Protein Intrinsic Disorder
2014
Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.
1993
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
1998 StandoutNature
Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins
1993
Kinetic Analysis by Fluorescence of the Interaction between Ras and the Catalytic Domain of the Guanine Nucleotide Exchange Factor Cdc25Mm
1998
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
2016
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
RING Domain E3 Ubiquitin Ligases
2009 Standout
Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G
1995
Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells
2014
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
1993
Metabolic reprogramming and cancer progression
2020 StandoutScience
The Regulation of Reactive Oxygen Species Production during Programmed Cell Death
1998
Cancer Genome Landscapes
2013 StandoutScience
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
Growth Factors and Cancer
1991 StandoutScience
Signal transduction via the MAP kinases: proceed at your own RSK.
1993 Standout
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Fission yeast orb 6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle
1998 StandoutNobel
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
2015
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
1996 StandoutScience
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
Increase in chitin as an essential response to defects in assembly of cell wall polymers in the ggp1delta mutant of Saccharomyces cerevisiae
1997
Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae.
1986
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.
1994
Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes
1993 Science
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Marco Vanoni being referenced
Structure and Regulation of the Multigene Family Controlling Maltose Fermentation in Budding Yeast
1989
CK2 activity is modulated by growth rate in Saccharomyces cerevisiae
2010
Order propensity of an intrinsically disordered protein, the cyclin‐dependent‐kinase inhibitor Sic1
2009
A Systems Biology Road Map for the Discovery of Drugs Targeting Cancer Cell Metabolism
2014
Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes
2009
Cloning and nucleotide sequences of two lipase genes from Candida cylindracea
1992
Extreme heat- and pressure-resistant 7-kDa protein P2 from the archaeonSulfolobus solfataricus is dramatically destabilized by a single-point amino acid substitution
1997
The Ras Guanine Nucleotide Exchange Factor CDC25Mm Is Present at the Synaptic Junction
1997
Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts
2006
The CK2 phosphorylation of catalytic domain of Cdc34 modulates its activity at the G1to S transition inSaccharomyces cerevisiae
2008
First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand
2009
Overexpression of the CDC25 gene, an upstream element of the ras/adenylyl cyclase pathway in Saccharomyces cerevisiae, allows immunological identification and characterization of its gene product
1990
In budding yeast, reactive oxygen species induce both RAS‐dependent and RAS‐independent cell cycle‐specific arrest
1999
A dominant negative RAS-specific guanine nucleotide exchange factor reverses neoplastic phenotype in K-ras transformed mouse fibroblasts
2000
Glutamine Deprivation Induces Abortive S-Phase Rescued by Deoxyribonucleotides in K-Ras Transformed Fibroblasts
2009
Ras-dependent carbon metabolism and transformation in mouse fibroblasts
2006
Redox‐Mediated Regulation of p21Waf1/Cip1 Expression Involves a Post‐Transcriptional Mechanism and Activation of the Mitogen‐Activated Protein Kinase Pathway
1997
Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.
1992
Characterization and Properties of Dominant-negative Mutants of the Ras-specific Guanine Nucleotide Exchange Factor CDC25Mm
1999
Acquired glucose sensitivity of k-ras transformed fibroblasts
2005
Macromolecular syntheses in the cell cycle mutant cdc25 of budding yeast
1984
Structural heterogeneity in populations of the budding yeast Saccharomyces cerevisiae
1983
A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins.
1992