Citation Impact
Citing Papers
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
2018 Science
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
2020
NF-κB signaling in inflammation
2017 Standout
Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly
2013
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation
2019
Chronic inflammation in the etiology of disease across the life span
2019 Standout
Mechanism and Regulation of NLRP3 Inflammasome Activation
2016 Standout
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
The molecular machinery of regulated cell death
2019 Standout
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
2011
Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases
2014
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Multiple molecular targets in breast cancer therapy by betulinic acid
2016
Pyroptosis: mechanisms and diseases
2021 Standout
Targeting apoptosis in cancer therapy
2020 Standout
TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex
2015
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Pyroptosis: A new frontier in cancer
2019 Standout
Atherosclerosis
2019 Standout
10 Years of GWAS Discovery: Biology, Function, and Translation
2017 Standout
Mitochondria as multifaceted regulators of cell death
2019 Standout
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
2016 Standout
<p>Reactive Oxygen Species: Drivers of Physiological and Pathological Processes</p>
2020 Standout
Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates
2016 StandoutNobel
Gasdermins: Effectors of Pyroptosis
2017 Standout
Click-EM for imaging metabolically tagged nonprotein biomolecules
2016 StandoutNobel
Dead Cert: Measuring Cell Death
2016
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
2015 Standout
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3
2019
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
2017 Standout
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
2019 Standout
Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity
2017 StandoutNobel
Paracaspase MALT1 Deficiency Protects Mice from Autoimmune-Mediated Demyelination
2013
Structure of yeast Ape1 and its role in autophagic vesicle formation
2015
Fluorescent chemosensors: the past, present and future
2017 Standout
Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy
2015
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization
2015
Gasdermins and their role in immunity and inflammation
2019
Bright Side of Lignin Depolymerization: Toward New Platform Chemicals
2018 Standout
Cytokine Storm
2020 Standout
Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G
2018
Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe
2015
Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application
2018 Standout
Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis
2016
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
2020
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation
2018
Activity-Based Profiling of Proteases
2014
The Essential Medicinal Chemistry of Curcumin
2017 Standout
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Promiscuity and Selectivity in Covalent Enzyme Inhibition: A Systematic Study of Electrophilic Fragments
2014
Works of Marcin Poręba being referenced
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1
2018
Current Strategies for Probing Substrate Specificity of Proteases
2010
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates
2014
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
2017
Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4
2015
Caspase Substrates and Inhibitors
2013
The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine
2012
S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors
2011
The new esters derivatives of betulin and betulinic acid in epidermoid squamous carcinoma treatment – In vitro studies
2015
Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease
2016
X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP
2012
Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses
2020
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling
2014
Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples
2018
Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides
2011
Emerging challenges in the design of selective substrates, inhibitors and activity‐based probes for indistinguishable proteases
2017
Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad
2013
Mechanism and specificity of the human paracaspase MALT1
2012