Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
Human Caspases: Activation, Specificity, and Regulation
2009
Discovery and engineering of enhanced SUMO protease enzymes
2018 StandoutNobel
Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7
2008
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
2011 Nature
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
2011
Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8
2013
Necroptosis and its role in inflammation
2015 StandoutNature
Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly
2013
Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation
2009
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Direct Catalytic Asymmetric Three‐Component Kabachnik–Fields Reaction
2008 StandoutNobel
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
2011
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
Breaking the chains: structure and function of the deubiquitinases
2009 Standout
A manganese catalyst for highly reactive yet chemoselective intramolecular C(sp3)–H amination
2015
The Catalytic Asymmetric Abramov Reaction
2014 StandoutNobel
cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
2011
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
2014
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Emerging Biological Principles of Metastasis
2017 Standout
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Thiourea‐Enhanced Flavin Photooxidation of Benzyl Alcohol
2007
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
2011
Necroptosis in development, inflammation and disease
2016
The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
2011
The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells
2012
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S
2014
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Proteome-wide covalent ligand discovery in native biological systems
2016 Nature
Protein‐Protected Au Clusters as a New Class of Nanoscale Biosensor for Label‐Free Fluorescence Detection of Proteases
2012
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila
2012 StandoutNobel
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry
2011
3d Transition Metals for C–H Activation
2018 Standout
Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3
2019
Synthesis of β-Aminophosphonates and -Phosphinates
2005
Atomically Precise Colloidal Metal Nanoclusters and Nanoparticles: Fundamentals and Opportunities
2016 Standout
Organic Photoredox Catalysis
2016 Standout
A Hafnium-Based Metal–Organic Framework as a Nature-Inspired Tandem Reaction Catalyst
2015 StandoutNobel
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
2019 Standout
The potential for caspases in drug discovery.
2010
Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity
2017 StandoutNobel
Diversity of Allosteric Regulation in Proteases
2012
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Development and Applications of Disulfonimides in Enantioselective Organocatalysis
2015 StandoutNobel
Catalytic Enantioselective Hydrophosphonylation of Aldehydes and Imines
2008
Regioselective synthesis of the 1-bromo-4-phenyl-tetrahydro-7-amino-benzocyclohepten-6-one, a subnanomolar aminopeptidase-N/CD13 inhibitor
2012
Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling
2013
Reactions of Alicyclic Epoxy Compounds with Nitrogen-Containing Nucleophiles
2004
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Cytokine Storm
2020 Standout
A Hafnium-Based Metal–Organic Framework as an Efficient and Multifunctional Catalyst for Facile CO2 Fixation and Regioselective and Enantioretentive Epoxide Activation
2014 StandoutNobel
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity
2011
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Sunflower trypsin inhibitor (SFTI-1) analogues of synthetic and biological origin via N→S acyl transfer: potential inhibitors of human Kallikrein-5 (KLK5)
2014 StandoutNobel
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
2017 Standout
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation
2018
Activity-Based Profiling of Proteases
2014
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
2009
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Atomically Precise Clusters of Noble Metals: Emerging Link between Atoms and Nanoparticles
2017 Standout
Works of Marcin Drąg being referenced
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1
2018
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC
2008
Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells
2009
Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors
2009
Emerging principles in protease-based drug discovery
2010
Current Strategies for Probing Substrate Specificity of Proteases
2010
α-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases
2005
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates
2014
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
2009
Metallo-aminopeptidase inhibitors
2010
SUMO-mediated regulation of NLRP3 modulates inflammasome activity
2018
Novel hydroxamic acid-related phosphinates: Inhibition of neutral aminopeptidase N (APN)
2007
Redox reaction between amino‐(3,4‐dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase
2002
Caspase Substrates and Inhibitors
2013
Current and prospective applications of non-proteinogenic amino acids in profiling of proteases substrate specificity
2012
Small Ubiquitin-related Modifier (SUMO)-specific Proteases
2007
Identification of very potent inhibitor of human aminopeptidase N (CD13)
2010
FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
2011
Stereoselective synthesis, solution structure and metal complexes of (1S,2S)-2-amino-1-hydroxyalkylphosphonic acids
2003
Regio- and stereoselective synthesis of 2-amino-1-hydroxy-2-aryl ethylphosphonic esters
2000
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
2008
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
2007
Synthesis of α1-(Cbz-aminoalkyl)-α2-(hydroxyalkyl)phosphinic esters
2005
Solution conformations of 2-amino-1-hydroxy-2-aryl ethylphosphonic acids and their diethyl esters
2002
Activation and Specificity of Human Caspase-10
2010
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis
2009
Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis
2016
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
2020
Mechanism and specificity of the human paracaspase MALT1
2012