Standout Papers
Citation Impact
Citing Papers
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25
2006 StandoutNobel
A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules
2003 StandoutScience
RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay in plants
2011
rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA
2011
Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
2003 StandoutScienceNobel
A Gene Expression Map for Caenorhabditis elegans
2001 Science
Functional Genomic Analysis of RNA Interference in C. elegans
2005 StandoutScienceNobel
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
2015 StandoutScienceNobel
Using RNA interference to identify genes required for RNA interference
2002
Rates of Behavior and Aging Specified by Mitochondrial Function During Development
2002 Science
Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans
2006 StandoutScienceNobel
Age-related changes of nuclear architecture in Caenorhabditis elegans
2005
An Extensive Class of Small RNAs in Caenorhabditis elegans
2001 StandoutScienceNobel
Bulk RNA degradation by nitrogen starvation‐induced autophagy in yeast
2014 StandoutNobel
Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae
2012
DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
2018 StandoutNobel
Regulatory elements of Caenorhabditis elegans ribosomal protein genes
2012
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
2013
Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs
2013
Regulation of Lipoprotein Assembly, Secretion and Fatty Acid β-Oxidation by Krüppel-Like Transcription Factor, klf-3
2013
Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
2010 Nature
Small RNA: can RNA interference be exploited for therapy?
2003
Cargo recognition and trafficking in selective autophagy
2014
The hedgehog‐related gene qua‐1 is required for molting in Caenorhabditis elegans
2006
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
2007 StandoutNobel
Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions
2003
Piwi and piRNAs Act Upstream of an Endogenous siRNA Pathway to Suppress Tc3 Transposon Mobility in the Caenorhabditis elegans Germline
2008
A Genome-Wide Screen Identifies 27 Genes Involved in Transposon Silencing in C. elegans
2003
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
2004
Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits
2014
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
2005 StandoutNobel
RNAi and HTS: exploring cancer by systematic loss-of-function
2004
Establishment of a tissue-specific RNAi system in C. elegans
2007
On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing
2001 StandoutNobel
A Role for Ubiquitin in Selective Autophagy
2009
MicroRNAs
2004 Standout
RNA interference—2001
2001
PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1
2012 StandoutNobel
A systematic RNAi screen for longevity genes in C. elegans
2005 StandoutNobel
Conservation and Coevolution in the Scale-Free Human Gene Coexpression Network
2004
Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription
2010 Nature
Repetitive Transgenes in C. elegans Accumulate Heterochromatic Marks and Are Sequestered at the Nuclear Envelope in a Copy-Number- and Lamin-Dependent Manner
2010
Oncogenic potential of a C.eleganscdc25 gene is demonstrated by a gain-of-function allele
2002
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity
2013 StandoutNobel
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
2001
MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline
2012 StandoutNobel
The Caenorhabditis elegans MAPK phosphatase VHP‐1 mediates a novel JNK‐like signaling pathway in stress response
2004
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence
2012 StandoutNatureNobel
From large networks to small molecules
2003
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Distinct Innate Immune Responses to Infection and Wounding in the C. elegans Epidermis
2008
Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans
2013
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN‐1
2009
A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis
2013
Enhanced neuronal RNAi in C. elegans using SID-1
2010 Nobel
A Pre-mRNA–Associating Factor Links Endogenous siRNAs to Chromatin Regulation
2011
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
2000
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity
2013
Restriction enzyme–generated siRNA (REGS) vectors and libraries
2004
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA
2011 StandoutNobel
A Whole-Genome RNAi Screen for C. elegans miRNA Pathway Genes
2007 StandoutNobel
A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport
2016 StandoutNobel
Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
2002 Standout
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans
2006
Novel Genomic cDNA Hybrids Produce Effective RNA Interference in Adult Drosophila
2002
ClpP Mediates Activation of a Mitochondrial Unfolded Protein Response in C. elegans
2007
RNA interference: gene silencing in the fast lane
2003
Regulation of Heterochromatin Assembly on Unpaired Chromosomes during Caenorhabditis elegans Meiosis by Components of a Small RNA-Mediated Pathway
2009
Network organization of the human autophagy system
2010 StandoutNature
Genome-Wide RNAi Analysis of Growth and Viability in Drosophila Cells
2004 Science
Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation
2005
Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy
2009 StandoutNobel
Selective autophagy mediated by autophagic adapter proteins
2011 Standout
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences
2005
fzr-1 and lin-35 /Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen
2002
Mitochondrial Respiratory Chain Deficiency inCaenorhabditis elegans Results in Developmental Arrest and Increased Life Span
2001
Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans
2019
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
2007 StandoutNature
A Conserved PMK-1/p38 MAPK Is Required in Caenorhabditis elegans Tissue-specific Immune Response to Yersinia pestis Infection
2010
Dynein Modifiers in C. elegans: Light Chains Suppress Conditional Heavy Chain Mutants
2007
Trans -splicing and polyadenylation of let-7 microRNA primary transcripts
2004
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening
2003
Killing the messenger: short RNAs that silence gene expression
2003
TOR Deficiency in C. elegans Causes Developmental Arrest and Intestinal Atrophy by Inhibition of mRNA Translation
2002
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
Diverse Chromatin Remodeling Genes Antagonize the Rb-Involved SynMuv Pathways in C. elegans
2006
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
2003 StandoutNobel
Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint
2012 Nobel
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
A resource for large-scale RNA-interference-based screens in mammals
2004
Minireview: The role of the vacuolar ATPase in nematodes
2011
Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans
2013 StandoutNobel
Unbiased Mapping of Transcription Factor Binding Sites along Human Chromosomes 21 and 22 Points to Widespread Regulation of Noncoding RNAs
2004
Identification of Genes Needed for Regeneration, Stem Cell Function, and Tissue Homeostasis by Systematic Gene Perturbation in Planaria
2005
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
2001 Standout
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
2006
Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins
2009
Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi
2003 Nature
Functional Genomic Analysis of C. elegans Molting
2005 StandoutNobel
Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses
2011
Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based RNAi Library
2004
Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans
2013
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
2004
Defining the Human Deubiquitinating Enzyme Interaction Landscape
2009
C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span
2006 Nobel
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
2006
Revealing the world of RNA interference
2004 StandoutNatureNobel
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
2002 StandoutNobel
Prevalence of off-target effects in Drosophila RNA interference screens
2006 Nature
Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1
2009
Two neurons mediate diet-restriction-induced longevity in C. elegans
2007 Nature
Mitochondrial Genome Content Is Regulated during Nematode Development
2002
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Dynamics and diversity in autophagy mechanisms: lessons from yeast
2009 StandoutNobel
The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans
2010
9 Quelling in Neurospora crassa
2002
Genes Required for Systemic RNA Interference in Caenorhabditis elegans
2004
TATA Binding Protein-Associated CK2 Transduces DNA Damage Signals to the RNA Polymerase III Transcriptional Machinery
2001
Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi
2002 StandoutNobel
11 RNAi (nematodes: Caenorhabditis elegans)
2002
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
2003 StandoutNature
Vacuolar (H+)-ATPases in Caenorhabditis elegans: What can we learn about giant H+ pumps from tiny worms?
2010
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
2009 StandoutNobel
A role for casein kinase 2α in the Drosophila circadian clock
2002 StandoutNatureNobel
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
2004 StandoutNatureNobel
DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage
2014
A Reduction in Intestinal Cell pH Due to Loss of the Caenorhabditis elegans Na+/H+ Exchanger NHX-2 Increases Life Span
2003
Germ-Cell Loss Extends C. elegans Life Span through Regulation of DAF-16 by kri-1 and Lipophilic-Hormone Signaling
2006
Genome-wide RNAi screening in Caenorhabditis elegans
2003
Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
2003
Selective autophagy in budding yeast
2012
The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans
2005 StandoutNobel
Requirement for the ERI/DICER Complex in Endogenous RNA Interference and Sperm Development in Caenorhabditis elegans
2009
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
2004
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
2005 StandoutScienceNobel
TOR Action in Mammalian Cells and in Caenorhabditis elegans
2004
Perinuclear P granules are the principal sites of mRNA export in adultC. elegansgerm cells
2010
Organellophagy: Eliminating cellular building blocks via selective autophagy
2014
Golgi‐mediated Glycosylation Determines Residency of the T2 RNase Rny1p in Saccharomyces cerevisiae
2013
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response
2009
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Developmental Genetics of Secretory Vesicle Acidification DuringCaenorhabditis elegansSpermatogenesis
2012
Hrr25 triggers selective autophagy–related pathways by phosphorylating receptor proteins
2014 StandoutNobel
Biogenesis and Cargo Selectivity of Autophagosomes
2011
Shared gene expression in distinct neurons expressing common selector genes
2011 Nobel
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
A comprehensive two-hybrid analysis to explore the yeast protein interactome
2001 Standout
A Genomewide RNAi Screen for Genes That Affect the Stability, Distribution and Function of P Granules in Caenorhabditis elegans
2009
The Temporal Patterning MicroRNA let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. elegans
2005
lin-35/Rb andubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis inC. elegans
2003
Ubiquitin-Like Protein 5 Positively Regulates Chaperone Gene Expression in the Mitochondrial Unfolded Protein Response
2006
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians
2003
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells
2003
cdc12p, a Protein Required for Cytokinesis in Fission Yeast, Is a Component of the Cell Division Ring and Interacts with Profilin
1997 StandoutNobel
High-Throughput Cloning of Temperature-Sensitive Caenorhabditis elegans Mutants with Adult Syncytial Germline Membrane Architecture Defects
2015
Genetic Analysis of Tissue Aging in Caenorhabditis elegans: A Role for Heat-Shock Factor and Bacterial Proliferation
2002
Autophagy: More Than a Nonselective Pathway
2012
Human DNA Repair Genes
2001 StandoutScienceNobel
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase
2004
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
2004 Standout
lin-35/Rb Cooperates With the SWI/SNF Complex to Control Caenorhabditis elegans Larval Development
2004
Genetic Analysis of theCaenorhabditis elegansGLH Family of P-Granule Proteins
2008
Combining biological networks to predict genetic interactions
2004
Small interfering RNA production by enzymatic engineering of DNA (SPEED)
2004
Works of Marc Sohrmann being referenced
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
2003 StandoutNature
Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease
2008
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
2000 StandoutNature
The dmf1/mid1 gene is essential for correct positioning of the division septum in fission yeast.
1996