Citation Impact
Citing Papers
Machine learning-assisted directed protein evolution with combinatorial libraries
2019 Nobel
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
GEMME: A Simple and Fast Global Epistatic Model Predicting Mutational Effects
2019
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
Structures of the CRISPR genome integration complex
2017 StandoutScienceNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Protein Conformational Switches: From Nature to Design
2012
Rapid construction of metabolite biosensors using domain-insertion profiling
2016
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
2011
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
The ensemble nature of allostery
2014 Nature
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Evolving strategies for enzyme engineering
2005 StandoutNobel
Accurate design of co-assembling multi-component protein nanomaterials
2014 StandoutNatureNobel
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Random multi-recombinant PCR for the construction of combinatorial protein libraries
2001
Libraries of hybrid proteins from distantly related sequences
2001 StandoutNobel
Protein building blocks preserved by recombination
2002 StandoutNobel
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Engineering allostery
2014
Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions
2010
Library analysis of SCHEMA‐guided protein recombination
2003 StandoutNobel
Engineering an allosteric transcription factor to respond to new ligands
2015 StandoutNobel
Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation
2022
Low-N protein engineering with data-efficient deep learning
2021
Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry
2004
Complete mapping of viral escape from neutralizing antibodies
2017
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
Engineering Allosteric Regulation into Biological Catalysts
2009
Computational de novo Design, and Characterization of an A2B2 Diiron Protein
2002
The coming of age of de novo protein design
2016 StandoutNatureNobel
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Reconstruction of Functional β-Propeller Lectins via Homo-oligomeric Assembly of Shorter Fragments
2006
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes
2007
Functional Expression of Horseradish Peroxidase in E. coli by Directed Evolution
1999 StandoutNobel
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
High efficiency family shuffling based on multi-step PCR and in vivo DNA recombination in yeast: statistical and functional analysis of a combinatorial library between human cytochrome P450 1A1 and 1A2
2000
Engineering explored
2014 StandoutNatureNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Towards the directed evolution of protein materials
2019
Modulating protein activity using tethered ligands with mutually exclusive binding sites
2015
Mutation effects predicted from sequence co-variation
2017
Evolution of new protein topologies through multistep gene rearrangements
2006
Self‐Assembly of 3,6‐Bis(4‐triazolyl)pyridazine Ligands with Copper(I) and Silver(I) Ions: Time‐Dependant 2D‐NOESY and Ultracentrifuge Measurements
2010
Structure-based Combinatorial Protein Engineering (SCOPE)
2002
DNA shuffling method for generating highly recombined genes and evolved enzymes
2001
Man-made enzymes — from design to in vitro compartmentalisation
2000
Exploring protein fitness landscapes by directed evolution
2009 StandoutNobel
Folding and Stability of a Primitive Protein
2005 StandoutNobel
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
General Method for Sequence-independent Site-directed Chimeragenesis
2003 StandoutNobel
Design of protein conformational switches
2006
Synthetic protein switches: design principles and applications
2014
De novo protein design by deep network hallucination
2021 StandoutNatureNobel
Directed Evolution of Gloeobacter violaceus Rhodopsin Spectral Properties
2014 StandoutNobel
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Library-Aided Probing of Linker Determinants in Hybrid Photoreceptors
2016
Precise assembly of complex beta sheet topologies from de novo designed building blocks
2015 StandoutNobel
Combinatorial approaches to engineering hybrid enzymes
2002
Caged Activators of Artificial Allosteric Protein Biosensors
2020
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
Copper(I)-Assembled [3]Rotaxane Whose Two Rings Act as Flapping Wings
2012 StandoutNobel
Reducing Codon Redundancy and Screening Effort of Combinatorial Protein Libraries Created by Saturation Mutagenesis
2012
Generalizable Protein Biosensors Based on Synthetic Switch Modules
2019
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Structural DNA Nanotechnology: State of the Art and Future Perspective
2014
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
2022 StandoutScienceNobel
DeMaSk: a deep mutational scanning substitution matrix and its use for variant impact prediction
2020
Induced allostery in the directed evolution of an enantioselective Baeyer–Villiger monooxygenase
2010
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Switchable Reporter Enzymes Based on Mutually Exclusive Domain Interactions Allow Antibody Detection Directly in Solution
2013
Fancy footwork in the sequence space shuffle
2006 StandoutNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
Enzyme Redesign
2001
Ultrahigh-throughput screening enables efficient single-round oxidase remodelling
2019
De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds
2016
Engineering allosteric regulation in protein kinases
2018
Protein Design by Directed Evolution
2008
On the conservative nature of intragenic recombination
2005 StandoutNobel
“Itching” for new strategies in protein engineering
1999 StandoutNobel
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Dynamic Control of Chiral Space in a Catalytic Asymmetric Reaction Using a Molecular Motor
2011 StandoutScienceNobel
Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations
2020
PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta
2010
Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins
2014
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions
2015 StandoutNobel
Works of Marc Ostermeier being referenced
Directed evolution of protein switches and their application to the creation of ligand-binding proteins
2005
Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells
2009
Mathematical expressions useful in the construction, description and evaluation of protein libraries
2005
The Creation of ITCHY Hybrid Protein Libraries
2003
Hybrid enzymes: manipulating enzyme design
1998
PFunkel: Efficient, Expansive, User-Defined Mutagenesis
2012
Engineering allosteric protein switches by domain insertion
2005
In Vitro Recombination of Non-Homologous Genes Can Result in Gene Fusions that Confer a Switching Phenotype to Cells
2011
Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 β-lactamase switch
2005
Ligand binding and allostery can emerge simultaneously
2007
Incremental truncation as a strategy in the engineering of novel biocatalysts
1999
Structure Prediction of Domain Insertion Proteins from Structures of Individual Domains
2008
Multifunctional “Clickates” as Versatile Extended Heteroaromatic Building Blocks: Efficient Synthesis via Click Chemistry, Conformational Preferences, and Metal Coordination
2007
A Comprehensive, High-Resolution Map of a Gene’s Fitness Landscape
2014
Protein Switch Engineering by Domain Insertion
2013
A Molecular Switch Created by In Vitro Recombination of Nonhomologous Genes
2004
Targeted DNA methylation in human cells using engineered dCas9-methyltransferases
2017
Construction of Protein Switches by Domain Insertion and Directed Evolution
2017
A combinatorial approach to hybrid enzymes independent of DNA homology
1999
Eukaryotic Protein Disulfide Isomerase Complements Escherichia coli dsbA Mutants and Increases the Yield of a Heterologous Secreted Protein with Disulfide Bonds
1996
Design of protein switches based on an ensemble model of allostery
2015
Non‐allosteric enzyme switches possess larger effector‐induced changes in thermodynamic stability than their non‐switch analogs
2013
Designing switchable enzymes
2009
Theoretical distribution of truncation lengths in incremental truncation libraries
2003
NMR characterization of an engineered domain fusion between maltose binding protein and TEM1 β‐lactamase provides insight into its structure and allosteric mechanism
2009
Protein fragment complementation in M.HhaI DNA methyltransferase
2005
Creation of an Allosteric Enzyme by Domain Insertion
2003
As easy as flipping a switch?
2007
Evolution of protein function by Domain swapping
2001
Environmental changes bridge evolutionary valleys
2016
A protein therapeutic modality founded on molecular regulation
2011
An externally tunable bacterial band-pass filter
2009
Combinatorial protein engineering by incremental truncation
1999
Creating multiple-crossover DNA libraries independent of sequence identity
2001
Construction of hybrid gene libraries involving the circular permutation of DNA
2001
Enzymatic protein switches built from paralogous input domains
2015