Standout Papers
Citation Impact
Citing Papers
What is the total number of protein molecules per cell volume? A call to rethink some published values
2013
Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems
2014
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions
2013 StandoutNobel
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
2014
Dynamic profiling of the protein life cycle in response to pathogens
2015 Science
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
2014
Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA
2014 Science
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
2015 Science
Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line
2016
Rationally engineered Cas9 nucleases with improved specificity
2015 StandoutScience
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease
2013
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
2015 Science
High-throughput mapping of regulatory DNA
2016
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
Improved Hematopoietic Differentiation Efficiency of Gene-Corrected Beta-Thalassemia Induced Pluripotent Stem Cells by CRISPR/Cas9 System
2014
The iCRISPR Platform for Rapid Genome Editing in Human Pluripotent Stem Cells
2014
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
2014 Standout
A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification
2014
Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs
2015
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Proteome Dynamics: Revisiting Turnover with a Global Perspective
2012
Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
2016
Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo
2018
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells
2014
WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system
2015
Precision cancer mouse models through genome editing with CRISPR-Cas9
2015
Characterization of Functional Reprogramming during Osteoclast Development Using Quantitative Proteomics and mRNA Profiling
2014
Protein synthesis rate is the predominant regulator of protein expression during differentiation
2013
Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs
2015
Structure and Engineering of Francisella novicida Cas9
2016
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9
2014 Nobel
Transcriptome and proteome quantification of a tumor model provides novel insights into post‐transcriptional gene regulation
2013
Precision genome engineering in lactic acid bacteria
2014
CRISPR-ERA: a comprehensive design tool for CRISPR-mediated gene editing, repression and activation: Fig. 1.
2015
Disruption of HPV16-E7 by CRISPR/Cas System Induces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical Cancer Cells
2014
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
2014 Standout
Cell-Penetrating Peptide-Mediated Delivery of TALEN Proteins via Bioconjugation for Genome Engineering
2014
Digital PCR to assess gene-editing frequencies (GEF-dPCR) mediated by designer nucleases
2016
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
2013 Standout
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
2013 Standout
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
2017
Isolation of single-base genome-edited human iPS cells without antibiotic selection
2014
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
2015
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
2015
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level
2017
RNA-guided gene activation by CRISPR-Cas9–based transcription factors
2013
Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2
2013
DNA targeting specificity of RNA-guided Cas9 nucleases
2013 Standout
Systematic analysis of CRISPR–Cas9 mismatch tolerance reveals low levels of off-target activity
2015
Cell type– and brain region–resolved mouse brain proteome
2015
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
2015
Circular RNAs are a large class of animal RNAs with regulatory potency
2013 StandoutNature
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
2015
A multifunctional AAV–CRISPR–Cas9 and its host response
2016
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
2016
Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
2017 Nature
Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos
2013
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
2013
Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System
2013
In Vitro Enzymology of Cas9
2014
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
2013
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
Classification and evolution of type II CRISPR-Cas systems
2014 StandoutNobel
Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells
2014
Efficient and Allele-Specific Genome Editing of Disease Loci in Human iPSCs
2014
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
2013
Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment
2015
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
2015
Induced Pluripotent Stem Cells Meet Genome Editing
2016
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
2016
Efficient genome editing in zebrafish using a CRISPR-Cas system
2013 Standout
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
2015
Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair
2016
Genome-Editing Technologies: Principles and Applications
2016
Sequence determinants of improved CRISPR sgRNA design
2015
Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a
2017
crRNA and tracrRNA guide Cas9-mediated DNA interference inStreptococcus thermophilus
2013
Comparison of Cas9 activators in multiple species
2016
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
2018
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
2015
Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus
2015
Targeted Genome Editing in Human Cells Using CRISPR/Cas Nucleases and Truncated Guide RNAs
2014
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
2015
Heritable genome editing in C. elegans via a CRISPR-Cas9 system
2013
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
2015
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
2014
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9
2015
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
2015
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
2013
CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity
2014
Inducible in vivo genome editing with CRISPR-Cas9
2015
Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection
2015
Saturation editing of genomic regions by multiplex homology-directed repair
2014 Nature
Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy
2015
Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications
2015
Targeted genomic rearrangements using CRISPR/Cas technology
2014
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
2014
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
2015
The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo
2014
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
2014 Nature
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Enabling functional genomics with genome engineering
2015
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
2015
CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes
2016
Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9
2013
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
2016
Highly efficient Cas9-mediated transcriptional programming
2015
Marker-free coselection for CRISPR-driven genome editing in human cells
2017
An Efficient Genotyping Method for Genome-modified Animals and Human Cells Generated with CRISPR/Cas9 System
2014
CRISPR-Cas
2013
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
2015
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
2015
A split-Cas9 architecture for inducible genome editing and transcription modulation
2015
sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites
2014
Exploiting CRISPR–Cas immune systems for genome editing in bacteria
2015
A decade of discovery: CRISPR functions and applications
2017
Easy quantitative assessment of genome editing by sequence trace decomposition
2014 Standout
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
2016
RNA-Guided Genome Editing in Plants Using a CRISPR–Cas System
2013
In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target
2015
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
2015
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
2013 Standout
Applications of CRISPR–Cas systems in neuroscience
2015
Base editing: precision chemistry on the genome and transcriptome of living cells
2018
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
2016
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Therapeutic genome editing: prospects and challenges
2015
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome
2015
Self‐Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing
2015
The structural biology of CRISPR-Cas systems
2015 StandoutNobel
CRISPR RNA–guided activation of endogenous human genes
2013
Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis
2013
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach
2015
Non-viral vectors for gene-based therapy
2014 Standout
Improved Cell-Penetrating Zinc-Finger Nuclease Proteins for Precision Genome Engineering
2015
Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System
2013
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
2014 Standout
Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair
2013
Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA
2014
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease
2014
Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements
2015
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
Genome-scale CRISPR pooled screens
2016
CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing
2014
Cas9 as a versatile tool for engineering biology
2013
Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications
2015
A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells
2016
Predictable and precise template-free CRISPR editing of pathogenic variants
2018 Nature
Crystal Structure of Staphylococcus aureus Cas9
2015
An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells
2014
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
2013
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
2015
RNA-guided genome editing à la carte
2013
Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila
2014
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
2013
Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells
2014
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
2014
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Cloning-free CRISPR
2015
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
2013
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Photoactivatable CRISPR-Cas9 for optogenetic genome editing
2015
High-throughput mapping of regulatory DNA
2016
One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering
2013
Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac
2014
CRISPR-mediated direct mutation of cancer genes in the mouse liver
2014 Nature
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Adeno-Associated Virus–Mediated Delivery of CRISPR–Cas Systems for Genome Engineering in Mammalian Cells
2016
CRISPR-Cas systems for editing, regulating and targeting genomes
2014 Standout
Editing DNA Methylation in the Mammalian Genome
2016
Genome engineering using the CRISPR-Cas9 system
2013 Standout
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
2015
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
2015
Nuclear domain ‘knock-in’ screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing
2015
Editing plant genomes with CRISPR/Cas9
2014
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
2014
High-throughput functional genomics using CRISPR–Cas9
2015
Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
2016
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution
2014
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
2015 Nature
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
2013 Standout
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
CRISPR/Cas9‐mediated genome engineering: An adeno‐associated viral (AAV) vector toolbox
2014
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNobel
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
2014
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
2014
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
2013
Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells
2016
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
2013 Nobel
Targeted Genome Editing of Sweet Orange Using Cas9/sgRNA
2014
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells
2015
High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells
2014 Nature
Quantitative Analysis of Fission Yeast Transcriptomes and Proteomes in Proliferating and Quiescent Cells
2012
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
2016
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
2014 Standout
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
2012 Standout
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
2016 Nature
Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions
2016
Genome Editing in Human Stem Cells
2014
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
2014
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
2016
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9
2015
Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA
2013
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system
2014
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
2013
Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9
2014
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Rapid Temporal Dynamics of Transcription, Protein Synthesis, and Secretion during Macrophage Activation
2014
Efficient gene editing in adult mouse livers via adenoviral delivery of CRISPR/Cas9
2014
Global quantification of mammalian gene expression control
2011 StandoutNature
TALEN or Cas9 – Rapid, Efficient and Specific Choices for Genome Modifications
2013
Small molecule–triggered Cas9 protein with improved genome-editing specificity
2015
The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive
2013
Genotyping with CRISPR-Cas-derived RNA-guided endonucleases
2014
Harnessing CRISPR–Cas systems for bacterial genome editing
2015
Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes
2017 StandoutNobel
Protein Engineering of Cas9 for Enhanced Function
2014
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
2013
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
2013
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
2015
Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
2015
Evaluation of sgRNA Target Sites for CRISPR-Mediated Repression of TP53
2014
Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells
2015
Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks
2019
DNase H Activity of Neisseria meningitidis Cas9
2015
Interplay between gene expression noise and regulatory network architecture
2012
CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection
2014
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing
2014
Adapting CRISPR/Cas9 for Functional Genomics Screens
2014
Safeguarding CRISPR-Cas9 gene drives in yeast
2015
Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality
2014
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
2014
Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs
2014
RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?
2013
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Genome-editing Technologies for Gene and Cell Therapy
2016
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
2014
Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing
2015
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
2013 StandoutNobel
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
2015
The Bacterial Origins of the CRISPR Genome-Editing Revolution
2015
Fanconi Anemia Gene Editing by the CRISPR/Cas9 System
2014
CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
2015
Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses
2015
Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage
2014
Genome Engineering with Targetable Nucleases
2014
A prudent path forward for genomic engineering and germline gene modification
2015 StandoutScienceNobel
GT-Scan: identifying unique genomic targets
2014
RNA-Guided Genome Editing for Target Gene Mutations in Wheat
2013
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9
2015
RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection
2014
Selection of chromosomal DNA libraries using a multiplex CRISPR system
2014
From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing
2015 Nobel
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
2014 Standout
Concerning RNA-guided gene drives for the alteration of wild populations
2014
The quantitative proteome of a human cell line
2011
Biallelic genome modification in F0Xenopus tropicalis embryos using the CRISPR/Cas system
2013
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
2014
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Cas9-Guide RNA Directed Genome Editing in Soybean
2015
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
2013 Standout
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
CasOT: a genome-wide Cas9/gRNA off-target searching tool
2014
CRISPR, the disruptor
2015 Nature
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Regulating gene drives
2014 Science
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
2013
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
2015
Optical Control of CRISPR/Cas9 Gene Editing
2015
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells
2013
Inactivation of the Human Papillomavirus E6 or E7 Gene in Cervical Carcinoma Cells by Using a Bacterial CRISPR/Cas RNA-Guided Endonuclease
2014
Male‐sterile maize plants produced by targeted mutagenesis of the cytochrome P 450‐like gene (MS 26) using a re‐designed I–C reI homing endonuclease
2013
Correlation of mRNA and protein abundance in the developing maize leaf
2014
Absolute quantification of microbial proteomes at different states by directed mass spectrometry
2011
Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining
2016
CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegans
2013
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
Cas9 Targeting and the CRISPR Revolution
2014 Science
A general strategy to construct small molecule biosensors in eukaryotes
2015 StandoutNobel
Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single‐guide RNA and carbohydrate selection
2014
Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA
2015
Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish
2013
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Cas9-mediated targeting of viral RNA in eukaryotic cells
2015
ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts
2015
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
2013 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Genomic impact of CRISPR immunization against bacteriophages
2013
Synthetic CRISPR RNA-Cas9–guided genome editing in human cells
2015
Rewriting a genome
2013 StandoutNatureNobel
System wide analyses have underestimated protein abundances and the importance of transcription in mammals
2014
CRISPR/Cas9-Mediated Targeted Mutagenesis in the Liverwort Marchantia polymorpha L.
2014
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
2013
TALEN‐ and CRISPR/Cas9‐Mediated Gene Editing in Human Pluripotent Stem Cells Using Lipid‐Based Transfection
2015
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
2014 StandoutNobel
Works of Marc Güell being referenced
Transcriptome Complexity in a Genome-Reduced Bacterium
2009 Science
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
Quantification of mRNA and protein and integration with protein turnover in a bacterium
2011
Strand-specific deep sequencing of the transcriptome
2010
Engineering and optimising deaminase fusions for genome editing
2016
Correlation of mRNA and protein in complex biological samples
2009
Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA)
2014
Optimization of scarless human stem cell genome editing
2013
Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
2015 Science