Citation Impact
Citing Papers
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
2012 StandoutScience
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Type I topoisomerase activity is required for proper chromosomal segregation in Escherichia coli
2001
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Linkage Map ofEscherichia coliK-12, Edition 10: The Traditional Map
1998
The Role of Replication-Associated Repair Factors on R-Loops
2017
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Ataxia telangiectasia mutated activation by transcription‐ and topoisomerase I‐induced DNA double‐strand breaks
2009 Nobel
Tuning in to Interference: R-Loops and Cascade Complexes in CRISPR Immunity
2012
Hyper-negative template DNA supercoiling during transcription of the tetracycline-resistance gene in topA mutants is largely constrained in vivo
1996
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
R loops: new modulators of genome dynamics and function
2015
Cellular roles of DNA topoisomerases: a molecular perspective
2002 Standout
Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination
2003
Porphobilinogen synthase, the first source of Heme's asymmetry
1995
Domains of Human Topoisomerase I and Associated Functions
1998
Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast
2011
Hyperphosphorylation of RNA Polymerase II in Response to Topoisomerase I Cleavage Complexes and Its Association with Transcription- and BRCA1-dependent Degradation of Topoisomerase I
2008
Roles of Topoisomerases in Maintaining Steady-state DNA Supercoiling in Escherichia coli
2000
Isolation and characterization of a topA mutant of Shigella flexneri
1993
In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants
2006 StandoutNobel
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
2019 StandoutNobel
Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
2010
Characterization of structural features important for T7 RNAP elongation complex stability reveals competing complex conformations and a role for the non-template strand in RNA displacement
1999
Bacterial and archeal type I topoisomerases
1998
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS
2000 StandoutNature
Transcription as a source of genome instability
2012
Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis
2005
Reduction of hRNase H2 activity in Aicardi–Goutières syndrome cells leads to replication stress and genome instability
2014
The Zn(II) Binding Motifs ofE. coliDNA Topoisomerase I Is Part of a High-Affinity DNA Binding Domain
1998
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions
2010
Why is transcription coupled to translation in bacteria?
2004
Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
2004
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Real-Time Kinetics of Gene Activity in Individual Bacteria
2005 Standout
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Cooperative relaxation of supercoils and periodic transcriptional initiation within polymerase batteries
1996
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
2003
The COG database: a tool for genome-scale analysis of protein functions and evolution
2000 Standout
Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription
2012
Genome instability: a mechanistic view of its causes and consequences
2008
Nucleic acid‐mediated inflammatory diseases
2008
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
AID mutant analyses indicate requirement for class-switch-specific cofactors
2003 StandoutNobel
Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis
2012
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans
2015 StandoutNobel
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability
2005
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
1998
Human DNA Damage Checkpoint Protein hRAD9 Is a 3′ to 5′ Exonuclease
2000 StandoutNobel
DNA structure in human RNA polymerase II promoters 1 1Edited by J. Karn
1998 StandoutNobel
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
2009
Analysis of Ribonucleotide Removal from DNA by Human Nucleotide Excision Repair
2015 StandoutNobel
Transcriptional responses to loss of RNase H2 in Saccharomyces cerevisiae
2012
Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability
2011
R Loops: From Transcription Byproducts to Threats to Genome Stability
2012
Biochemical analysis of TREX complex recruitment to intronless and intron‐containing yeast genes
2004 StandoutNobel
Quadruplex DNA: sequence, topology and structure
2006 Standout
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
Microbiome dynamics of human epidermis following skin barrier disruption
2012
Interactions between mRNA Export Commitment, 3′-End Quality Control, and Nuclear Degradation
2002 StandoutNobel
Functions of the gene products of Escherichia coli
1993
Hpr1 Is Preferentially Required for Transcription of Either Long or G+C-Rich DNA Sequences in Saccharomyces cerevisiae
2001
Breast cancer classification and prognosis based on gene expression profiles from a population-based study
2003 Standout
Mammalian DNA topoisomerase IIIα is essential in early embryogenesis
1998
R loops stimulate genetic instability of CTG·CAG repeats
2009
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
2009 Standout
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Distinguishing the Roles of Topoisomerases I and II in Relief of Transcription-Induced Torsional Stress in Yeast rRNA Genes
2010
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
An Evolutionary View of the Mechanism for Immune and Genome Diversity
2012 StandoutNobel
The connection between transcription and genomic instability
2002
Considerations of transcriptional control mechanisms: Do TFIID–core promoter complexes recapitulate nucleosome-like functions?
1997
Artificial Molecular Machines
2015 Standout
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
The Complete Genome Sequence of Escherichia coli K-12
1997 StandoutScience
Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein
2011
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
2002 StandoutScienceNobel
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
A Genomic Perspective on Protein Families
1997 StandoutScience
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Natural tri- to hexapeptides self-assemble in water to amyloid β-type fiber aggregates by unexpected α-helical intermediate structures
2011
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
2004 Standout
Mechanism of R-Loop Formation at Immunoglobulin Class Switch Sequences
2007
DNA Topoisomerases: Structure, Function, and Mechanism
2001 Standout
AID to overcome the limitations of genomic information
2005 StandoutNobel
Works of Marc Drolet being referenced
Depletion of RNase HI activity in Escherichia coli lacking DNA topoisomerase I leads to defects in DNA supercoiling and segregation
2008
Escherichia coli DNA Topoisomerase I Inhibits R-loop Formation by Relaxing Transcription-induced Negative Supercoiling
1999
Roles of DNA Topoisomerases in Transcription
1994
Effects of RNA polymerase modifications on transcription‐induced negative supercoiling and associated R‐loop formation
2004
Relaxation of Transcription-induced Negative Supercoiling Is an Essential Function of Escherichia coli DNA Topoisomerase I
1999
The problem of hypernegative supercoiling and r-loop formation in transcription
2003
R-loop-dependent hypernegative supercoiling in Escherichia coli topA mutants preferentially occurs at low temperatures and correlates with growth inhibition
1999
RNase HI overproduction is required for efficient full‐length RNA synthesis in the absence of topoisomerase I in Escherichia coli
2004
RNase H Overproduction Corrects a Defect at the Level of Transcription Elongation during rRNA Synthesis in the Absence of DNA Topoisomerase I in Escherichia coli
2000
Nucleotide sequence of thehemXgene, the third member of the Uro operon ofEscherichia coliK12
1988
Isolation and nucleotide sequence of the hemA gene of Escherichia coli K12
1989
Roles of DNA Topoisomerases in the Regulation of R-loop Formation in Vitro
1997
Isolation of the topB gene encoding DNA topoisomerase III as a multicopy suppressor of topA null mutations in Escherichia coli
2000
Nucleotide sequence of the hemB gene of Escherichia coli K12
1988
Growth inhibition mediated by excess negative supercoiling: the interplay between transcription elongation, R‐loop formation and DNA topology
2005
Development of a Rapid and Sensitive Test for Identification of Major Pathogens in Bovine Mastitis by PCR
2001
Hypernegative Supercoiling Inhibits Growth by Causing RNA Degradation
2008
Molecular cloning and sequencing of the hemD gene of Escherichia coli K-12 and preliminary data on the Uro operon
1987
DNA Topoisomerases Regulate R-loop Formation during Transcription of the rrnB Operon in Escherichia coli
1997
Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I.
1995
Hypernegative supercoiling of the DNA template during transcription elongation in vitro.
1994