Standout Papers
- Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release (2006)
- Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels (2010)
- Pore region of TRPV3 ion channel is specifically required for heat activation (2008)
- Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents (2012)
- Piezo proteins are pore-forming subunits of mechanically activated channels (2012)
- Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane (2009)
- Piezo1 ion channel pore properties are dictated by C-terminal region (2015)
- The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles (2013)
Citation Impact
Citing Papers
Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
2012
Thermosensitive TRP channel pore turret is part of the temperature activation pathway
2010
The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels
2013
Video-Rate Far-Field Optical Nanoscopy Dissects Synaptic Vesicle Movement
2008 StandoutScienceNobel
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
Macromolecular-scale resolution in biological fluorescence microscopy
2006 StandoutNobel
Cryo-EM structure of OSCA1.2 from Oryza sativa elucidates the mechanical basis of potential membrane hyperosmolality gating
2019
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
2014
PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana
2021 StandoutNobel
Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
2015
Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces
2016
Maturation of active zone assembly by Drosophila Bruchpilot
2009
Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers
2019
Species differences and molecular determinant of TRPA1 cold sensitivity
2013
Mechanotransduction in the muscle spindle
2014
A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
2018
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
2016
PIEZO2 is required for mechanotransduction in human stem cell–derived touch receptors
2014
Localized force application reveals mechanically sensitive domains of Piezo1
2016
Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels
2017
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
2018
Piezo1 Channels Are Inherently Mechanosensitive
2016 StandoutNobel
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
2015
Functional Role for Piezo1 in Stretch-evoked Ca2+ Influx and ATP Release in Urothelial Cell Cultures
2014
Diffraction-unlimited all-optical imaging and writing with a photochromic GFP
2011 StandoutNatureNobel
Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain
2009
Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons
2015
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
2016
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
The Primary cilium calcium channels and their role in flow sensing
2014
Mechanical stress activates NMDA receptors in the absence of agonists
2017
The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration
2019 StandoutNobel
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct β Sandwich Fold
2014
Kinetic and Energetic Analysis of Thermally Activated TRPV1 Channels
2010
Molecular force transduction by ion channels – diversity and unifying principles
2012
Piezo1-dependent regulation of urinary osmolarity
2016
Mechano-Gated Ion Channels in Sensory Systems
2013
Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap
2020
Stressed podocytes—mechanical forces, sensors, signaling and response
2017
Slower Piezo1 Inactivation in Dehydrated Hereditary Stomatocytosis (Xerocytosis)
2013
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis
2015
Quantifying and Modeling the Temperature-Dependent Gating of TRP Channels
2012
Merkel Cells Transduce and Encode Tactile Stimuli to Drive Aβ-Afferent Impulses
2014
Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
2016 StandoutNobel
Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance
2019
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
2019 Nature
Runx1 Controls Terminal Morphology and Mechanosensitivity of VGLUT3-expressing C-Mechanoreceptors
2013
Force-induced conformational changes in PIEZO1
2019 NatureNobel
piezo2bRegulates Vertebrate Light Touch Response
2013
Hierarchical assembly of presynaptic components in defined C. elegans synapses
2006
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function
2016
Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons
2015
Multi-protein assemblies underlie the mesoscale organization of the plasma membrane
2014 StandoutNobel
Fluorescent probes for super-resolution imaging in living cells
2008 Standout
Biallelic Loss of Proprioception-Related PIEZO2 Causes Muscular Atrophy with Perinatal Respiratory Distress, Arthrogryposis, and Scoliosis
2016
Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix
2017
Shear stress-induced Ca2+ mobilization in MDCK cells is ATP dependent, no matter the primary cilium
2013
The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors
2015
The Purified Mechanosensitive Channel TREK-1 Is Directly Sensitive to Membrane Tension
2013
Structure–functional intimacies of transient receptor potential channels
2009
OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis
2014 Nature
Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain
2013
Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels
2015
Structure and mechanogating of the mammalian tactile channel PIEZO2
2019 Nature
Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia
2015 StandoutNobel
Wide‐field subdiffraction RESOLFT microscopy using fluorescent protein photoswitching
2007 StandoutNobel
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses
2009 StandoutNobel
The Presynaptic Active Zone
2012 StandoutNobel
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
2012 Nature
Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch
2014
Sensory mechanotransduction at membrane-matrix interfaces
2014
Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration
2012
The Role of PIEZO2 in Human Mechanosensation
2016
The Coupling between Synaptic Vesicles and Ca2+ Channels Determines Fast Neurotransmitter Release
2007 Nobel
Protonation of the Human PIEZO1 Ion Channel Stabilizes Inactivation
2015
TMIE Is an Essential Component of the Mechanotransduction Machinery of Cochlear Hair Cells
2014
Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations
2013 StandoutNobel
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
2013 StandoutNobel
Mechanically Activated Ion Channels
2015 StandoutNobel
Piezos thrive under pressure: mechanically activated ion channels in health and disease
2017 StandoutNobel
An Integrated Micro- and Macroarchitectural Analysis of the Drosophila Brain by Computer-Assisted Serial Section Electron Microscopy
2010
Molecular mechanisms of mechanotransduction in mammalian sensory neurons
2011
Rapid Temperature Jump by Infrared Diode Laser Irradiation for Patch-Clamp Studies
2009
Piezo2 is the principal mechanotransduction channel for proprioception
2015 StandoutNobel
Vagal Sensory Neuron Subtypes that Differentially Control Breathing
2015
Piezo1
2012
Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
2019
Thermo-TRP Channels: Biophysics of Polymodal Receptors
2010
Distinct Roles of TRP Channels in Auditory Transduction and Amplification in Drosophila
2013
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila
2011 Nature
A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel
2020
DEG/ENaC but Not TRP Channels Are the Major Mechanoelectrical Transduction Channels in a C. elegans Nociceptor
2011
Piezo1 is required for outflow tract and aortic valve development.
2020
Mechanical stretch triggers rapid epithelial cell division through Piezo1
2017 Nature
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex
2018
Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel
2015
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
2015
TRPA1 Contributes to Cold Hypersensitivity
2010 StandoutNobel
Fiji: an open-source platform for biological-image analysis
2012 Standout
Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels
2019
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
2018
Mechanosensory molecules and circuits in C. elegans
2014
Integrating the active process of hair cells with cochlear function
2014
The foraging gene of Drosophila melanogaster: Spatial‐expression analysis and sucrose responsiveness
2007
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Structural determinants of gating in the TRPV1 channel
2009
Supraresolution Imaging in Brain Slices using Stimulated-Emission Depletion Two-Photon Laser Scanning Microscopy
2009
Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels
2016
Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology
2017
Molecular organization of the presynaptic active zone
2006
Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile
2018
Superresolution Imaging of Chemical Synapses in the Brain
2010
Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation
2012 Nature
Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors
2016
Recessive PIEZO2 stop mutation causes distal arthrogryposis with distal muscle weakness, scoliosis and proprioception defects
2016
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
2008 StandoutNatureNobel
Conserved Residues within the Putative S4–S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels
2010
Human PIEZO1: Removing Inactivation
2013
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Direct recording and molecular identification of the calcium channel of primary cilia
2013 Nature
Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels
2016
Piezo1 plays a role in erythrocyte volume homeostasis
2013
Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons
2016
Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix
2007
Gating the mechanical channel Piezo1
2012
Structure and mechanogating mechanism of the Piezo1 channel
2018 Nature
Mechanosensing is critical for axon growth in the developing brain
2016
Mammalian touch catches up
2015
The Chimeric Approach Reveals That Differences in the TRPV1 Pore Domain Determine Species-specific Sensitivity to Block of Heat Activation
2011
TMHS Is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells
2012
Nanoscale resolution in GFP-based microscopy
2006 StandoutNobel
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
A role for Piezo2 in EPAC1-dependent mechanical allodynia
2013
Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel
2012
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
2010 StandoutNobel
RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone
2011 StandoutNobel
Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells
2010 Standout
Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six
2014 StandoutNobel
Piezo channels
2017
Disorders of red cell volume regulation
2013
How We Feel: Ion Channel Partnerships that Detect Mechanical Inputs and Give Rise to Touch and Pain Perception
2012
Identification and Analysis of Putative Homologues of Mechanosensitive Channels in Pathogenic Protozoa
2013
A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons
2016
Architecture of the mammalian mechanosensitive Piezo1 channel
2015 Nature
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization
2017 StandoutNobel
Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel
2018 Nature
Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2
2018
Heterologous Expression of the Piezo1-ASIC1 Chimera Induces Mechanosensitive Currents with Properties Distinct from Piezo1
2017
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin
2011 StandoutNobel
Sensing pressure with ion channels
2012
Merkel cells and neurons keep in touch
2014 StandoutNobel
BrainAligner: 3D registration atlases of Drosophila brains
2011
Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS
2012
Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
2017
TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration
2020
A family of distal arthrogryposis type 5 due to a novel PIEZO2 mutation
2015
Gain‐of‐function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway
2019
Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels
2011
The mechanosensitive Piezo1 channel is required for bone formation
2019
Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells
2013
Piezo1 links mechanical forces to red blood cell volume
2015 StandoutNobel
Far-Field Optical Nanoscopy
2007 StandoutScienceNobel
Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides
2015
Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms
2020
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling
2018
Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy
2008 Science
Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes
2017
The Hv1 proton channel responds to mechanical stimuli
2016
RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
2011 StandoutScienceNobel
Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures
2016
How cells channel their stress: Interplay between Piezo1 and the cytoskeleton
2017
Conductance and block of hair-cell mechanotransducer channels in transmembrane channel–like protein mutants
2014
Piezo2: A Candidate Biomarker for Visceral Hypersensitivity in Irritable Bowel Syndrome?
2017
TRP Channels and Pain
2013 StandoutNobel
Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl
2014
Yoda1 analogue (D ooku1) which antagonizes Y oda1‐evoked activation of P iezo1 and aortic relaxation
2018
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
2013 StandoutNobel
Structure-guided examination of the mechanogating mechanism of PIEZO2
2019
Targeting Piezo1 unleashes innate immunity against cancer and infectious disease
2020
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice
2018 StandoutNobel
SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS
2006
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K + channels
2014 Nobel
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Polycystins and partners: proposed role in mechanosensitivity
2014
Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis
2019
The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells
2015
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Feeling Force: Physical and Physiological Principles Enabling Sensory Mechanotransduction
2015
Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels
2014
Super-Resolution Fluorescence Microscopy
2009 Standout
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
2016
Live-cell imaging of dendritic spines by STED microscopy
2008 StandoutNobel
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
2011
Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4
2017
Mammalian TRP ion channels are insensitive to membrane stretch
2019
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1
2010
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1
2013
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
2014
PIEZO2 mediates injury-induced tactile pain in mice and humans
2018
Piezo’s membrane footprint and its contribution to mechanosensitivity
2018 Nobel
Stiffened lipid platforms at molecular force foci
2013
Chemical activation of the mechanotransduction channel Piezo1
2015 StandoutNobel
Structure-based membrane dome mechanism for Piezo mechanosensitivity
2017 Nobel
OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
2018 StandoutNobel
The Physiology of Mechanoelectrical Transduction Channels in Hearing
2014
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2
2015
Polymodal Ligand Sensitivity of TRPA1 and Its Modes of Interactions
2009
Works of Manuela Schmidt being referenced
A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila
2010
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Piezo1 ion channel pore properties are dictated by C-terminal region
2015 StandoutNobel
Pore region of TRPV3 ion channel is specifically required for heat activation
2008 StandoutNobel
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Non-NMDA-Type Glutamate Receptors Are Essential for Maturation But Not for Initial Assembly of Synapses atDrosophilaNeuromuscular Junctions
2006
Glutamate receptor dynamics organizing synapse formation in vivo
2005
Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in Drosophila
2006
Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents
2012 StandoutNobel
Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in Drosophila
2006
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons
2016