Standout Papers
Citation Impact
Citing Papers
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions
2008 Science
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
2009 StandoutNobel
Metastasis-Associated Protein 1/Nucleosome Remodeling and Histone Deacetylase Complex in Cancer
2012
Circadian oscillation of nucleotide excision repair in mammalian brain
2009 StandoutNobel
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
2007 StandoutNobel
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
2012
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
2007 Science
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
2007
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation
2005
Inflammation and cancer
2002 StandoutNature
Cullin 4A-mediated Proteolysis of DDB2 Protein at DNA Damage Sites Regulates in Vivo Lesion Recognition by XPC
2006
Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
2009
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
2008
Biochemical analysis of human Dna2
2006
Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells
2013
The emerging role of nuclear architecture in DNA repair and genome maintenance
2009
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
2009 Nature
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
2007 StandoutNobel
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints
2010
H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility
2003
Cell-cycle checkpoints and cancer
2004 StandoutNature
Chk1 and Chk2 kinases in checkpoint control and cancer
2003
Transcription-coupled DNA repair: two decades of progress and surprises
2008
Acetylation Regulates the DNA End-Trimming Activity of DNA Polymerase β
2002
Crystal Structure of Bacteriophage T4 5′ Nuclease in Complex with a Branched DNA Reveals How Flap Endonuclease-1 Family Nucleases Bind Their Substrates
2007
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
2006
CUL4A Abrogation Augments DNA Damage Response and Protection against Skin Carcinogenesis
2009
Base excision repair in yeast and mammals
2000
The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage
2009
A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability
2009
Histone H2AX
2003
Regulatory Roles of p21 and Apurinic/Apyrimidinic Endonuclease 1 in Base Excision Repair
2001
Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development
2003
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
2007
Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice
2003
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
DNA damage checkpoints in mammals
2005
ATR: an essential regulator of genome integrity
2008
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
2011 Nature
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
2006
Rapid activation of ATM on DNA flanking double-strand breaks
2007
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Human Xip1 (C2orf13) Is a Novel Regulator of Cellular Responses to DNA Strand Breaks
2007
Regulation of DNA double-strand break repair pathway choice
2007
Modeling of Flap Endonuclease Interactions with DNA Substrate
2003
Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair
2001
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement Synthesis
2008
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
The Chk2 protein kinase
2004
Checkpoint Mediators: Relaying Signals from DNA Strand Breaks
2003
Repair of Strand Breaks by Homologous Recombination
2013
Cellular senescence and DNA repair
2006
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
2008 Nature
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Repair of Endogenous DNA Damage
2000 StandoutNobel
Checking on DNA damage in S phase
2004
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Multiple functions of MRN in end-joining pathways during isotype class switching
2009
The DNA Damage Response: Ten Years After
2007
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Tip60: Connecting chromatin to DNA damage signaling
2010
BRCA1 and its toolbox for the maintenance of genome integrity
2009
DNA damage signalling guards against activated oncogenes and tumour progression
2007
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
2007 Nature
Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency
2009
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
2008 Nature
Structural Determinants for Substrate Binding and Catalysis by the Structure-specific Endonuclease XPG
2003
TFIIH: from transcription to clinic
2001
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
2009 Nature
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
53BP1, an activator of ATM in response to DNA damage
2004
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
2010
γH2AX and cancer
2008
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase and increases its DNA substrate utilisation efficiency: implications for DNA repair
2004
Mechanism of Stimulation of Human DNA Ligase I by the Rad9-Rad1-Hus1 Checkpoint Complex
2006 StandoutNobel
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
2009
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
2009
Cdc7-Dbf4 and the Human S Checkpoint Response to UVC
2007 StandoutNobel
Identification of genes that protect theC. elegansgenome against mutations by genome-wide RNAi
2003
Ubiquitin signalling in DNA replication and repair
2010
PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites
2007
Crosstalk between histone modifications during the DNA damage response
2009
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Oncofetal reprogramming in tumour development and progression
2022
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins
2009
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
2006 Standout
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene
2003
Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
2004
Damaged DNA-binding Protein DDB Stimulates the Excision of Cyclobutane Pyrimidine Dimers in Vitro in Concert with XPA and Replication Protein A
2001
RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
2007
Nucleotide Excision Repair
2005 StandoutNobel
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
2007
53BP1 facilitates long-range DNA end-joining during V(D)J recombination
2008 Nature
The combined status of ATM and p53 link tumor development with therapeutic response
2009
UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex
2005
DNA Ligase I and Proliferating Cell Nuclear Antigen Form a Functional Complex
2001
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
2010
The cellular response to DNA double-strand breaks: defining the sensors and mediators
2003
Post-replicative base excision repair in replication foci
1999
Analysis of Interactions Between Mismatch Repair Initiation Factors and the Replication Processivity Factor PCNA
2005
A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage
2015
ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes
2001
Requirement of the MRN complex for ATM activation by DNA damage
2003
Structural basis for recruitment of human flap endonuclease 1 to PCNA
2004
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
2008
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Far-Field Optical Nanoscopy
2007 StandoutScienceNobel
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
53BP1: function and mechanisms of focal recruitment
2009
DNA MISMATCH REPAIR
2005
Quality Control by DNA Repair
1999 StandoutScienceNobel
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin
2008
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
2006
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Control of skin cancer by the circadian rhythm
2011 StandoutNobel
Phospho‐dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
2008
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
2007
In Vitro Reconstitution of the Schizosaccharomyces pombe Alternative Excision Repair Pathway
2000
Surviving the Breakup: The DNA Damage Checkpoint
2006
Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.
2007
The role of the DNA damage response pathways in brain development and microcephaly: Insight from human disorders
2008
Haploinsufficiency of t e lomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita
2005 StandoutNobel
Flap Endonuclease 1: A Central Component of DNA Metabolism
2004
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
2008 StandoutNobel
Mechanism and Regulation of Class Switch Recombination
2008
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
2010
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells
2007
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy
2006
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Reconstitution of Human DNA Polymerase δ Using Recombinant Baculoviruses
2002
Works of Manuel Stucki being referenced
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells
2011
Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention
2004
The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage
2014
Regulation of Human Flap Endonuclease-1 Activity by Acetylation through the Transcriptional Coactivator p300
2001
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
2004
MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
2005
Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair
2007
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
MDC1 is required for the intra-S-phase DNA damage checkpoint
2003 Nature
Long Patch Base Excision Repair with Purified Human Proteins
1999
In Eukaryotic Flap Endonuclease 1, the C Terminus Is Essential for Substrate Binding
2001
Dual mode of interaction of DNA polymerase ϵ with proliferating cell nuclear antigen in primer binding and DNA synthesis
1999
DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
2007
Mammalian base excision repair by DNA polymerases δ and ε
1998
Histone H2A.X Tyr142 phosphorylation: A novel sWItCH for apoptosis?
2009
MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
2006
Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
2008
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
2010
Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK
2000
Okazaki fragment processing: Modulation of the strand displacement activity of DNA polymerase δ by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1
2001