Citation Impact
Citing Papers
Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of T H 2 Inflammation
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Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-Presenting Cells
2004
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Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages
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Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
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2008
Arginase I Suppresses IL-12/IL-23p40–Driven Intestinal Inflammation during Acute Schistosomiasis
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Francisella tularensis Live Vaccine Strain Induces Macrophage Alternative Activation as a Survival Mechanism
2008
IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype
2002
Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation
2012
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
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2000 Nature
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Alternative versus classical macrophage activation during experimental African trypanosomosis
2001
Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
2000
Evaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) lyme vaccines in healthy adults
1996
Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance
2008
Safety and Immunogenicity of an Outer Surface Protein A Vaccine in Subjects with Previous Lyme Disease
1995
Leishmaniasis
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2003
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
2008
The IL-21 receptor augments Th2 effector function and alternative macrophage activation
2006
Cellular and molecular mechanisms of fibrosis
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Altered macrophage differentiation and immune dysfunction in tumor development
2007
Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages
2012
IFN-γ and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension
2002
A guide to immunometabolism for immunologists
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Other Functions, Other Genes
1999
The immunobiology of Th1 polarization in high‐pathology schistosomiasis
2004
Progressive Loss of Striatal Neurons Causes Motor Dysfunction in MND2 Mutant Mice and Is Not Prevented by Bcl-2
2002
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
2006
Pulmonary fibrosis: pathogenesis, etiology and regulation
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Perspective on the development of vaccines against Lyme disease
1991
Alternative activation of macrophages: Immune function and cellular biology
2009
Protective immune mechanisms in helminth infection
2007 Standout
The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity
2008
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Development of Lyme Arthritis in Mice Deficient in Inducible Nitric Oxide Synthase
1999
Macrophages: Master Regulators of Inflammation and Fibrosis
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Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
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2001
Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1
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Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
2007
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells
2008
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity
2004
Repertoire of microglial and macrophage responses after spinal cord injury
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Granulomas in schistosome and mycobacterial infections: a model of local immune responses
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Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells
2008
Vaccination against Lyme Disease with RecombinantBorrelia burgdorferiOuter-Surface Lipoprotein A with Adjuvant
1998 Standout
Effective clearance of intracellular Leishmania majorin vivo requires Pten in macrophages
2008 StandoutNobel
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
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TH2 Cytokines and Allergic Challenge Induce Ym1 Expression in Macrophages by a STAT6-dependent Mechanism
2002
IL-4 Receptor Signaling Is Required for Mannose Receptor Expression by Macrophages Recruited to Granulomata but not Resident Cells in Mice Infected with Schistosoma mansoni
2003
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
2003
P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon γ and the IL-13 decoy receptor
2004
Upregulation of Arginase Expression in Wound-Derived Fibroblasts
2002
Alternative activation of ruminant macrophages by Fasciola hepatica
2007
Inhibition of arginase in rat and rabbit alveolar macrophages by Nω‐hydroxy‐D ,L ‐indospicine, effects on L ‐arginine utilization by nitric oxide synthase
1997
Fibrotic disease and the TH1/TH2 paradigm
2004 Standout
Inflammatory cell infiltration of tumors: Jekyll or Hyde
2007
Arginase I induction in macrophages, triggered by Th2‐type cytokines, supports the growth of intracellular Leishmania parasites
2002
Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
2006
A non‐classical type of alveolar macrophage response to Trichinella spiralis infection
2004
FIZZ1 and Ym as Tools to Discriminate between Differentially Activated Macrophages
2002
Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy
2008
Alternatively Activated Antigen-Presenting Cells: Molecular Repertoire, Immune Regulation, and Healing
2001
Alternatively activated macrophages in helminth infections
2007
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
2009
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
2002
L-arginine metabolism in myeloid cells controls T-lymphocyte functions
2003
Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease
2007
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
2009
Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4-, and IFN-β-dependent
2010
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
2012 Standout
Alternative Activation of Macrophages: Mechanism and Functions
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Cancer immunotherapy comes of age
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2004
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Origin and physiological roles of inflammation
2008 StandoutNature
NOS-2 Mediates the Protective Anti-Inflammatory and Antifibrotic Effects of the Th1-Inducing Adjuvant, IL-12, in a Th2 Model of Granulomatous Disease
2000
The macrophage: Past, present and future
2007
Comparative properties of arginases
1996
Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact
2000
Lipid raft: A floating island of death or survival
2012
Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine
2002
Points of control in inflammation
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Inflammation, Atherosclerosis, and Coronary Artery Disease
2005 Standout
Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis
2006
Alternative Macrophage Activation Is Essential for Survival during Schistosomiasis and Downmodulates T Helper 1 Responses and Immunopathology
2004
Macrophage biology in development, homeostasis and disease
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Protein‐energy malnutrition as a risk factor for visceral leishmaniasis: a review
2009
Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages
2014
Regulation of immune responses by L-arginine metabolism
2005
Cancer-related inflammation
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Alternatively activated macrophages in protozoan infections
2007
Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism
2006
IL-4/IL-13-Dependent Alternative Activation of Macrophages but Not Microglial Cells Is Associated with Uncontrolled Cerebral Cryptococcosis
2009
Cationic Amino Acid Transporter-2 Regulates Immunity by Modulating Arginase Activity
2008
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
SHIP Represses the Generation of Alternatively Activated Macrophages
2005
Exploring the full spectrum of macrophage activation
2008 Standout
Suppression of TH2-type allergic reactions by helminth infection
2007
Lipopolysaccharides Indirectly Stimulate Apoptosis and Global Induction of Apoptotic Genes in Fibroblasts
2003
Alternative activation of macrophages
2003 Standout
Adipose tissue macrophages
2007
Pathogen Recognition and Innate Immunity
2006 Standout
Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin
2014
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
2007 Standout
Macrophage activation and polarization
2007 Standout
The immunobiology of schistosomiasis
2002 Standout
Inflammasomes in health and disease
2012 StandoutNature
The divergent roles of alternatively activated macrophages in helminthic infections
2007
Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
2016 Standout
Cytokines and atherosclerosis: a comprehensive review of studies in mice
2008
Control of Macrophage Activation and Function by PPARs
2010
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis.
1994
Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA
1990 Science
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
Peroxisome proliferator-activated receptor γ (PPARγ) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer
2006
Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
2010
Global Gene Expression Profiles During Acute Pathogen-Induced Pulmonary Inflammation Reveal Divergent Roles for Th1 and Th2 Responses in Tissue Repair
2003
Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-γ in IL-12/IL-18-stimulated mouse macrophage populations
2004
Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease
2005
Novel Effector Molecules in Type 2 Inflammation: Lessons Drawn from Helminth Infection and Allergy
2006
Biochemical and functional characterization of three activated macrophage populations
2006
Regulation and Function of the Interleukin 13 Receptor α 2 During a T Helper Cell Type 2–dominant Immune Response
2003
Interleukin-5 (IL-5) Augments the Progression of Liver Fibrosis by Regulating IL-13 Activity
2006
Antagonistic effect of NK cells on alternatively activated monocytes: a contribution of NK cells to CTL generation
2002
Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences
2005
The many faces of macrophage activation
2003
Nitric oxide and the immune response
2001 Standout
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
2000 Standout
Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes
2010
F4/80+ Alternatively Activated Macrophages Control CD4+ T Cell Hyporesponsiveness at Sites Peripheral to Filarial Infection
2006
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T Cells
2004
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes
2009
Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages
2002
Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-10
2002
Fast structural responses of gap junction membrane domains to AB5 toxins
2013 StandoutNobel
Obstacles and opportunities for understanding macrophage polarization
2011
Murine gammaherpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages
2008
The role of microglia and macrophages in the pathophysiology of the CNS
1999
Reactive Oxygen Species and 12/15-Lipoxygenase Contribute to the Antiproliferative Capacity of Alternatively Activated Myeloid Cells Elicited during Helminth Infection
2005
Cytolytic and membrane-perturbing properties of lysophosphatidylcholine
1979
Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung
2009
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation
2004
Causes and consequences of higher Leishmania infantum burden in patients with kala‐azar: a study of 625 patients
2017
Pattern of Macrophage Activation in Yersinia‐Resistant and Yersinia‐Susceptible Strains of Mice
2007
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
Markers of macrophage differentiation in experimental silicosis
2004
Immunopathology of schistosomiasis
2006
Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production
2001
2000
Innate Immune Responses to Lung-Stage Helminth Infection Induce Alternatively Activated Alveolar Macrophages
2006
Alternative Activation of Macrophages: An Immunologic Functional Perspective
2008 Standout
Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines
1998
Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses
2002
Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells
1998
Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
2006 StandoutNobel
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment
2009
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
2000 StandoutScienceNobel
Overexpression of Interleukin-10 by Activated T Lymphocytes Inhibits Atherosclerosis in LDL Receptor–Deficient Mice by Altering Lymphocyte and Macrophage Phenotypes
2002
Dynamics of lung macrophage activation in response to helminth infection
2008
Arginase I Induction duringLeishmania majorInfection Mediates the Development of Disease
2005
Tick Salivary Gland Extract Inhibits Killing ofBorrelia afzeliiSpirochetes by Mouse Macrophages
2001
Molecular Mechanisms RegulatinG Th1 Immune Responses
2003
Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice
2000
Alternative versus classical macrophage activation during experimental African trypanosomosis
2001
ABrugia malayiHomolog of Macrophage Migration Inhibitory Factor Reveals an Important Link Between Macrophages and Eosinophil Recruitment During Nematode Infection
2001
Nitric Oxide Mediation of Active Immunosuppression Associated With Graft-Versus-Host Reaction
1999
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent
2004
Induction of Intracellular Arginase Activity Does not Diminish the Capacity of Macrophages to Produce Nitric Oxide in vitro
1999
Arginase modulates nitric oxide production in activated macrophages
1998
The Serpin Proteinase Inhibitor 9 Is an Endogenous Inhibitor of Interleukin 1β–Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells
2000
M2b Monocytes Predominated in Peripheral Blood of Severely Burned Patients
2010
The Inhibition of Arginase by Nω-Hydroxy-l -Arginine Controls the Growth of Leishmania Inside Macrophages
2001
Differential regulation of macrophage arginine metabolism: a proposed role in wound healing
1997
Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.
1992
Th2-like immune response in radiation-induced lung fibrosis
2011
IL-13 Effector Functions
2003
Nitric Oxide-Independent CTL Suppression during Tumor Progression: Association with Arginase-Producing (M2) Myeloid Cells
2003
Arginine metabolism: nitric oxide and beyond
1998 Standout
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity
2008
Abilities of OspA proteins from different seroprotective groups of Borrelia burgdorferi to protect hamsters from infection
1995
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.
2001
Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies
2003
Impairment of Alternative Macrophage Activation Delays Cutaneous Leishmaniasis in Nonhealing BALB/c Mice
2006
Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice
2000
Works of Manuel Modolell being referenced
Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism
2001
Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype
1998
Th1/Th2-Regulated Expression of Arginase Isoforms in Murine Macrophages and Dendritic Cells
1999
Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation
2006
Involvement of protein kinase A in the induction of arginase in murine bone marrow-derived macrophages
1997
Determination of arginase activity in macrophages: a micromethod
1994
Killing of Borrelia burgdorferi by macrophages is dependent on oxygen radicals and nitric oxide and can be enhanced by antibodies to outer surface proteins of the spirochete
1994
Arginine Transport Is Impaired in C57Bl/6 Mouse Macrophages as a Result of a Deletion in the Promoter of Slc7a2 (CAT2), and Susceptibility to Leishmania Infection Is Reduced
2013
Arginase Activity in the Blood of Patients with Visceral Leishmaniasis and HIV Infection
2013
Age-Related Alteration of Arginase Activity Impacts on Severity of Leishmaniasis
2008
Involvement of c-Jun NH2-Terminal Kinase Activation and c-Jun in the Induction of Apoptosis by the Ether Phospholipid 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
1998
Oxidation of NG‐hydroxyl‐l ‐arginine to nitric oxide mediated by respiratory burst: an alternative pathway to NO synthesis
1997
Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites
2017
Arginase Induction by Suppressors of Nitric Oxide Synthesis (IL-4, IL-10 and PGE2) in Murine Bone-Marrow-Derived Macrophages
1995
Granulocyte-macrophage colony-stimulating factor increases l -arginine transport through the induction of CAT2 in bone marrow-derived macrophages
2005
Arginase Activity - A Marker of Disease Status in Patients with Visceral Leishmaniasis in Ethiopia
2013
Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines
1995
Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis
2009
Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy
2007
Lipopolysaccharide-induced Apoptosis of Macrophages Determines the Up-regulation of Concentrative Nucleoside Transporters Cnt1 and Cnt2 through Tumor Necrosis Factor-α-dependent and -independent Mechanisms
2001
Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation
1998
Infection of C57BL/10ScCr and C57BL/10ScNCr mice withLeishmania majorreveals a role for Toll-like receptor 4 in the control of parasite replication
2004
Selective destruction of human leukemic cells by alkyl-lysophospholipids.
1978
Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan ParasiteLeishmania major
2004
Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).
1997
Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.
1990
Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
2005
Differential impact ofl -arginine deprivation on the activation and effector functions of T cells and macrophages
2008
Coiling phagocytosis is the preferential phagocytic mechanism for Borrelia burgdorferi
1992
Arginine Transport via Cationic Amino Acid Transporter 2 Plays a Critical Regulatory Role in Classical or Alternative Activation of Macrophages
2006
Divergent effects of GM‐CSF and TGFβ 1 on bone marrow‐ derived macrophage arginase‐1 activity, MCP‐1 expression, and matrix‐metalloproteinase‐12: a potential role during arteriogenesis
2003
TH1/TH2 dichotomy of murine CD4 T-cells is reflected in two alternate metabolic states of murine macrophages characterized by NO-synthase versus arginase induction
1997