Standout Papers
Citation Impact
Citing Papers
p21 Loss Cooperates with INK4 Inactivation Facilitating Immortalization and Bcl-2 –Mediated Anchorage-Independent Growth of Oncogene-Transduced Primary Mouse Fibroblasts
2007
Molecular Dissection of Formation of Senescence-Associated Heterochromatin Foci
2007
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Tissue-specific p19 Arf regulation dictates the response to oncogenic K-ras
2010
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements
2013
Meta-hallmarks of aging and cancer
2023
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Recurrent turnover of senescent cells during regeneration of a complex structure
2015
Mice with hyper-long telomeres show less metabolic aging and longer lifespans
2019
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
2006
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study
2013
Hallmarks of Cancer: The Next Generation
2011 Standout
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
2012
Glycogen Synthase Kinase-3 Couples AKT-dependent Signaling to the Regulation of p21Cip1 Degradation
2002
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
The landscape of human tissue and cell type specific expression and co-regulation of senescence genes
2022
BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration
2009
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
2012
A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation
2010
DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells
2011
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
2007
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
2011
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
2014 Standout
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
2008
Senescence-messaging secretome: SMS-ing cellular stress
2009
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
2007
Role of p21WAF1/CIP1 as an attenuator of both proliferative and drug-induced apoptotic signals in BCR-ABL-transformed hematopoietic cells
2007
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
2011
Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence
2013
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
2010 Nature
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
2011 StandoutNatureNobel
Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease
2012
Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
2011
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
2012
Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity
2012
Cellular senescence: when bad things happen to good cells
2007 Standout
Direct cell reprogramming is a stochastic process amenable to acceleration
2009 Nature
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Role of cellular senescence in hepatic wound healing and carcinogenesis
2012
Pro-senescence therapy for cancer treatment
2011
EMT and Dissemination Precede Pancreatic Tumor Formation
2012 Standout
Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells
2007
The centrosome and mitotic spindle apparatus in cancer and senescence
2010
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
2010
Geriatric muscle stem cells switch reversible quiescence into senescence
2014 Nature
p53 — a Jack of all trades but master of none
2009
Cellular senescence in aging and age-related disease: from mechanisms to therapy
2015 Standout
The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenance
2010
Lung Cancer
2008 Standout
Sox2 expression in breast tumours and activation in breast cancer stem cells
2011
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
2012
Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction
2013
Hallmarks of aging: An expanding universe
2023 Standout
p21Waf1is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate
2010
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
2010
Living on a break: cellular senescence as a DNA-damage response
2008
Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
2021
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
2008
Cellular senescence predicts treatment outcome in metastasised colorectal cancer
2010
BrafV600E cooperates with Pten loss to induce metastatic melanoma
2009
Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation
2009
Dexamethasone Reduces Sensitivity to Cisplatin by Blunting p53-Dependent Cellular Senescence in Non-Small Cell Lung Cancer
2012
Progress in understanding reprogramming to the induced pluripotent state
2011
Global heterochromatin loss
2012
Direct lineage conversions: unnatural but useful?
2011
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
2006 Nature
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
2009
Autophagy mediates the mitotic senescence transition
2009
Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability
2012
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
2010 Standout
Enhancing Chemotherapy Efficacy in Pten-Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
2014
Senescence impairs successful reprogramming to pluripotent stem cells
2009
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
2006
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
2011 Nature
Models, mechanisms and clinical evidence for cancer dormancy
2007
Anti-ageing and rejuvenating effects of quercetin
2010
p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
2009
Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence
2007 StandoutNobel
Telomere length, stem cells and aging
2007
Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema
2013
Accumulation of senescent cells in mitotic tissue of aging primates
2006
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
2006
Forging a signature of in vivo senescence
2015
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Oncogene-Induced Senescence Does Not Require the p16INK4a or p14ARF Melanoma Tumor Suppressors
2009
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
p21 in cancer: intricate networks and multiple activities
2009 Standout
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
2013 Nature
Immune-mediated mechanisms influencing the efficacy of anticancer therapies
2015
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
2006
Restoration of p53 function leads to tumour regression in vivo
2007 Nature
Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor orto down-regulation of the receptors
2006
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
2008 StandoutNobel
The essence of senescence: Figure 1.
2010 Standout
Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
2013
PRAK Is Essential for ras-Induced Senescence and Tumor Suppression
2007
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
2010 Nature
Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
2011
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
2010
Cellular senescence: putting the paradoxes in perspective
2010
Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis
2010
Induced pluripotent stem cells and reprogramming: seeing the science through the hype
2009 StandoutNobel
Classical and Nonclassical Intercellular Communication in Senescence and Ageing
2020
BRAFE600 in benign and malignant human tumours
2007
The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing
2009
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
2008 Standout
The common biology of cancer and ageing
2007 Nature
Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence
2009
Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
2009
Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008
Intraoperative detection and removal of microscopic residual sarcoma using wide‐field imaging
2012 StandoutNobel
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Senolytic CAR T cells reverse senescence-associated pathologies
2020 Nature
Oncogene-induced senescence: the bright and dark side of the response
2010
Cellular senescence and its effector programs
2014
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
2009 Nature
The quest to slow ageing through drug discovery
2020
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Role of shelterin in cancer and aging
2010
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
2018 Standout
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
2007
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
2009
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
2013
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma
2006
Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies
2012
Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis
2012
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
CDK Inhibitors: Cell Cycle Regulators and Beyond
2008
The role of senescent cells in ageing
2014 StandoutNature
Efficiencies and Mechanisms of Nuclear Reprogramming
2010 StandoutNobel
Cytoplasmic DNA: sources, sensing, and role in aging and disease
2021
Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
2010
The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity
2015
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
2009 Nature
The Hallmarks of Aging
2013 Standout
Senescence and the SASP: many therapeutic avenues
2020
A negative feedback signaling network underlies oncogene-induced senescence
2006
Accelerated telomere reduction and hepatocyte senescence in tolerated human liver allografts
2014
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
HIF1α delays premature senescence through the activation of MIF
2006
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
2012
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
A Novel Role for High-Mobility Group A Proteins in Cellular Senescence and Heterochromatin Formation
2006
Is cellular senescence an example of antagonistic pleiotropy?
2012
Actions of human telomerase beyond telomeres
2008
Molecular evolution of FOXP2, a gene involved in speech and language
2002 StandoutNatureNobel
The Regulation of INK4/ARF in Cancer and Aging
2006
Induced Neuronal Cells: How to Make and Define a Neuron
2011 StandoutNobel
DNA methylation and cellular reprogramming
2010
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
2006 Nature
Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A)
2010
Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors
2011 StandoutNobel
Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase
2006
The role of cellular senescence in cardiac disease: basic biology and clinical relevance
2021
Cell fusion induced by ERVWE1 or measles virus causes cellular senescence
2013
Unmasking senescence: context-dependent effects of SASP in cancer
2019
Inflammatory networks during cellular senescence: causes and consequences
2010
Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells
2005
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
2008
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1
2005
Geroconversion of aged muscle stem cells under regenerative pressure
2014
Cellular senescence: from physiology to pathology
2014 Standout
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Switching stem cell state through programmed germ cell reprogramming
2011
Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
2013
A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma
2010
Senescence and apoptosis: dueling or complementary cell fates?
2014
A High Glycolytic Flux Supports the Proliferative Potential of Murine Embryonic Stem Cells
2007
Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells
2008
HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction
2014
Cellular Senescence - its role in cancer and the response to ionizing radiation
2011
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
2007
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response
2008 Nobel
Aging, Cellular Senescence, and Cancer
2012 Standout
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Cellular senescence controls fibrosis in wound healing
2010
ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development
2005
Lysosome-mediated processing of chromatin in senescence
2013
Histone variant macroH2A confers resistance to nuclear reprogramming
2011 StandoutNobel
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
2012
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Recent Stem Cell Advances: Induced Pluripotent Stem Cells for Disease Modeling and Stem Cell–Based Regeneration
2010 StandoutNobel
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
2012
Cisplatin induces cell cycle arrest and senescence via upregulating P53 and P21 expression in HepG2 cells.
2013
Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?
2013
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
2012 StandoutNobel
Four faces of cellular senescence
2011 Standout
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
2012 StandoutNobel
Senescence‐associated β‐galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence
2014
Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts
2013
Mouse Models to Disentangle the Hallmarks of Human Aging
2018
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
2006
Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors
2002
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
2016 Science
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
2008 Standout
Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin
2010
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
Increased expression of senescence markers in cystic fibrosis airways
2013
Cellular senescence in development, regeneration and disease
2019
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Lamin B1 loss is a senescence-associated biomarker
2012
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Caenorhabditis elegans responses to bacteria from its natural habitats
2016 StandoutNobel
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
2020
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53
2009
The Molecular Balancing Act of p16INK4a in Cancer and Aging
2013
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
2006
Works of Manuel Collado being referenced
WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway
2009
BCR-ABL and Interleukin 3 Promote Haematopoietic Cell Proliferation and Survival through Modulation of Cyclin D2 and p27Kip1 Expression
2001
Cell senescence is an antiviral defense mechanism
2016
Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1
2000
The Ink4/Arf locus is a barrier for iPS cell reprogramming
2009 Nature
The Senescent Side of Tumor Suppression
2005
RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
2021
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
2007
Cellular Senescence in Cancer and Aging
2007 Standout
Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
2011
Senescence in premalignant tumours
2005 Nature
Histone macroH2A isoforms predict the risk of lung cancer recurrence
2009
Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice
2004
Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer
2014 Nature
Identification of a nuclear export signal in the KSHV latent protein LANA2 mediating its export from the nucleus
2005
Antiviral action of the tumor suppressor ARF
2006
Limited Role of Murine ATM in Oncogene-Induced Senescence and p53-Dependent Tumor Suppression
2009
Anti‐aging activity of the Ink4/Arf locus
2009
Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression
2006
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
TGFβ2-induced senescence during early inner ear development
2019
The power and the promise of oncogene-induced senescence markers
2006
Senescence in tumours: evidence from mice and humans
2009
Resistance to viral infection of super p53 mice
2005
Advances toward More Efficient Targeted Delivery of Nanoparticles in Vivo: Understanding Interactions between Nanoparticles and Cells
2017