Citation Impact
Citing Papers
Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo
2015
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
2005 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
The use of mRNA display to select high-affinity protein-binding peptides
2001 StandoutNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation
2001 StandoutNobel
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity
1998 StandoutNobel
CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless
1998 StandoutNobel
Cycling vrille Expression Is Required for a Functional Drosophila Clock
1999 StandoutNobel
The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila
1998 StandoutNobel
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Inflammation and cancer
2002 StandoutNature
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase
2001
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
JAKs, STATs and Src kinases in hematopoiesis
2002
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Phage display as a tool for the directed evolution of enzymes
2003
Negative Regulators of Cytokine Signaling
2001
The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2
2001
Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus
1998 StandoutNobel
Peptide ligation and its application to protein engineering
1999
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
1998 StandoutNobel
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
The von Hippel–Lindau tumor suppressor protein
2001 StandoutNobel
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
2003
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Adding New Chemistries to the Genetic Code
2010
Unraveling hot spots in binding interfaces: progress and challenges
2002
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
2002
In vitro selection of nucleic acids and proteins: what are we learning?
1999
A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
2018
1.4 .ANG. Structure of Photoactive Yellow Protein, a Cytosolic Photoreceptor: Unusual Fold, Active Site, and Chromophore
1995
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Drosophila Clock Can Generate Ectopic Circadian Clocks
2003 StandoutNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
Man-made enzymes — from design to in vitro compartmentalisation
2000
The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior
2000 StandoutNobel
Cytokine Signaling in 2002
2002 Standout
Perspectives on Oxygen Sensing
1999 StandoutNobel
A role for casein kinase 2α in the Drosophila circadian clock
2002 StandoutNatureNobel
The CRY1 Blue Light Photoreceptor of Arabidopsis Interacts with Phytochrome A In Vitro
1998
Identification of the platelet ADP receptor targeted by antithrombotic drugs
2001 StandoutNatureNobel
SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis
1999
Evolution of Aldolase Antibodies in Vitro : Correlation of Catalytic Activity and Reaction-based Selection
2003
Why the Rat-1 Fibroblast Should Replace the SCN as the In Vitro Model of Choice
1998 StandoutNobel
STATs: transcriptional control and biological impact
2002 Standout
Photoactive yellow protein: A structural prototype for the three-dimensional fold of the PAS domain superfamily
1998
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Oocyte–follicle cell interactions during ovarian follicle development, as seen by high resolution scanning and transmission electron microscopy in humans
2006
Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
2000
BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase
2004
Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography
1997 Science
Chemical Glycobiology
2001 StandoutScienceNobel
Changes of free calcium levels with stages of the cell division cycle
1985 StandoutNatureNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
SOCS Proteins: Negative Regulators of Cytokine Signaling
2001 Standout
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
Crystal Structure of the Aequorea victoria Green Fluorescent Protein
1996 StandoutScienceNobel
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
1999
Synthesis of Native Proteins by Chemical Ligation
2000
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila
2000 StandoutNobel
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
2001
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
2002
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Molecular breeding: The natural approach to protein design
2001
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
THE FINE STRUCTURE OF PRONUCLEAR DEVELOPMENT AND FUSION IN THE SEA URCHIN, ARBACIA PUNCTULATA
1968
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation
2001
A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis
2002
Suppressors of Cytokine Signaling Proteins Are Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance
2002
Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses
1998 StandoutScienceNobel
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
2002
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
2001
Critical Analysis of Antibody Catalysis
2000
ADP Receptors on Platelets
1996
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
Works of Manuel Baca being referenced
Negative Regulation of Cytokine Signaling by the SOCS Proteins
1999
Affinity Maturation of Leukemia Inhibitory Factor and Conversion to Potent Antagonists of Signaling
2004
Structural engineering of the HIV‐1 protease molecule with a β‐turn mimic of fixed geometry
1993
Crystal structure of the human 4-1BB/4-1BBL complex
2018
Complete Chemical Structure of Photoactive Yellow Protein: Novel Thioester-Linked 4-Hydroxycinnamyl Chromophore and Photocycle Chemistry
1994
Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4
2000
Enhanced Catalysis of Oxime-Based Bioconjugations by Substituted Anilines
2013
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
1999
Structure−Function Analysis of a Phage Display-Derived Peptide That Binds to Insulin-like Growth Factor Binding Protein 1
2001
SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation
2002
FINE STRUCTURE OF THE HUMAN OVUM IN THE PRONUCLEAR STAGE
1966
Chemical Ligation of Cysteine-Containing Peptides: Synthesis of a 22 kDa Tethered Dimer of HIV-1 Protease
1995
The fine structure of human follicular oocytes
1967
Probing the structural basis of the catalytic activity of HIV-1 PR through total chemical protein synthesis
1998
Phage display of a catalytic antibody to optimize affinity for transition-state analog binding
1997
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
2000
Catalytic contribution of flap-substrate hydrogen bonds in "HIV-1 protease" explored by chemical synthesis.
1993
Adenosine Diphosphate (ADP)-Induced ⍺-Granules Release from Platelets of Native Whole Blood Is Reduced by Ticlopidine but Not by Aspirin or Dipyridamole
1986