Standout Papers
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
STAR: ultrafast universal RNA-seq aligner
2012 Standout
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Helix‐7 in Argonaute2 shapes the microRNA seed region for rapid target recognition
2017
Phosphorylation of Argonaute proteins affects mRNA binding and is essential for micro RNA ‐guided gene silencing in vivo
2017
Global RNA recognition patterns of post‐transcriptional regulators Hfq and CsrA revealed by UV crosslinking in vivo
2016
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease
2013
A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
2016
Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
2010
Expanded identification and characterization of mammalian circular RNAs
2014
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
2015
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets
2018
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data
2011
Xist localization and function: new insights from multiple levels
2015
RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4
2015
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders
2015
Engineering precision nanoparticles for drug delivery
2020 Standout
Pairing beyond the Seed Supports MicroRNA Targeting Specificity
2016
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
The RNA Binding Protein Quaking Regulates Formation of circRNAs
2015 Standout
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
2013
LincRNA-p21 Suppresses Target mRNA Translation
2012
Regulation of microRNA function in animals
2018 Standout
Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)
2016
irCLIP platform for efficient characterization of protein–RNA interactions
2016
Systematic Transcriptome Wide Analysis of lncRNA-miRNA Interactions
2013
The evolution of evolvability in microRNA target sites in vertebrates
2013
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression
2015 Nature
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins
2015
Gene expression regulation mediated through reversible m6A RNA methylation
2014
Circular RNAs are a large class of animal RNAs with regulatory potency
2013 StandoutNature
Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS
2013
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
2013
Posttranscriptional m6A Editing of HIV-1 mRNAs Enhances Viral Gene Expression
2016
Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis
2014
Multivalent Recruitment of Human Argonaute by GW182
2017
Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR
2011
Cyclic Dinucleotides and the Innate Immune Response
2013
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
2013 StandoutNobel
Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements
2013
A network-biology perspective of microRNA function and dysfunction in cancer
2016
Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin
2011
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
2015 Standout
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC
2012
Reading RNA methylation codes through methyl-specific binding proteins
2014
Structural mechanism of cytosolic DNA sensing by cGAS
2013 Nature
MicroRNA target site identification by integrating sequence and binding information
2013
Loss of miR-10a Activates Lpo and Collaborates with Activated Wnt Signaling in Inducing Intestinal Neoplasia in Female Mice
2013
Deciphering flavivirus–host interactions using quantitative proteomics
2020
N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection
2016
Widespread context dependency of microRNA-mediated regulation
2014
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
2015 Standout
RNA-based recognition and targeting: sowing the seeds of specificity
2017 StandoutNobel
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
2014
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges
2013
Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP
2015
miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
2013
Identification and consequences of miRNA–target interactions — beyond repression of gene expression
2014
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
2013 Standout
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
Interactions, localization, and phosphorylation of the m6A generating METTL3–METTL14–WTAP complex
2018
The hedgehog signaling network
2003
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
2014 Standout
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
A Dynamic Search Process Underlies MicroRNA Targeting
2015
Global mapping of miRNA-target interactions in cattle (Bos taurus)
2017 StandoutNobel
Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates
2014
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
2005
Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data
2011
m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program
2017
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms
2007
doRiNA: a database of RNA interactions in post-transcriptional regulation
2011
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
2011 Standout
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
2011 Standout
The evolutionary journey of Argonaute proteins
2014
Structural Foundations of RNA Silencing by Argonaute
2017
RNA-binding proteins in neurodegeneration: Seq and you shall receive
2015
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
iCLIP: Protein–RNA interactions at nucleotide resolution
2013
Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2
2003
Metazoan MicroRNAs
2018 Standout
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
2014
miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
2015 StandoutNobel
The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
2014
Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition
2014
The widespread regulation of microRNA biogenesis, function and decay
2010 Standout
Divergent target recognition by coexpressed 5′-isomiRs of miR-142-3p and selective viral mimicry
2015
Sequence requirements for RNA binding by HuR and AUF1
2012
A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration
2016 StandoutNobel
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
2018
An alternative mode of microRNA target recognition
2012
A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins
2011
Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting
2012
Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals
2018
Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins
2012 Nobel
Competition between target sites of regulators shapes post-transcriptional gene regulation
2014
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
2015 Standout
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
2017
AUF1 facilitates microRNA-mediated gene silencing
2017
Dissecting noncoding and pathogen RNA–protein interactomes
2014
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
2013
Protein-RNA networks revealed through covalent RNA marks
2015
DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs
2012
Desperately seeking microRNA targets
2010
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
2003
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
2012 Standout
Protein–RNA interactions: new genomic technologies and perspectives
2012
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer
2017 StandoutNobel
Functional Interplay between RNA-Binding Protein HuR and microRNAs
2012
Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase
2015
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Altered Neuronal and Circuit Excitability in Fragile X Syndrome
2015
Unambiguous Identification of miRNA:Target Site Interactions by Different Types of Ligation Reactions
2014
The hallmarks of cancer
2012 Standout
RNA-binding proteins in human genetic disease
2020
Loss of the abundant nuclear non-coding RNAMALAT1is compatible with life and development
2012
CLIPZ: a database and analysis environment for experimentally determined binding sites of RNA-binding proteins
2010
Pre-mRNA splicing: where and when in the nucleus
2011
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
2009 Nature
HITS‐CLIP: panoramic views of protein–RNA regulation in living cells
2010
Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
2013
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Argonaute CLIP-Seq reveals miRNA targetome diversity across tissue types
2014
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
N6-methyladenosine-dependent regulation of messenger RNA stability
2013 StandoutNature
Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing
2017
MS2-TRAP (MS2-tagged RNA affinity purification): Tagging RNA to identify associated miRNAs
2012
Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
2013
Reading, writing and erasing mRNA methylation
2019 Standout
Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation
2013
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
2013
Endogenous microRNA sponges: evidence and controversy
2016 Standout
Degradation of Cellular miR-27 by a Novel, Highly Abundant Viral Transcript Is Important for Efficient Virus Replication In Vivo
2012
The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines
2012
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape
2015
Dicer recognizes the 5′ end of RNA for efficient and accurate processing
2011 Nature
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding
2013
Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance
2014
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
2014
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
2017
starBase: a database for exploring microRNA–mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data
2010
Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression
2013
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
2014
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Context-dependent functions of specific microRNAs in neuronal development
2010
The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
2012
Experimental strategies for microRNA target identification
2011
N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
2015 StandoutNature
N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
2017
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data
2013 Standout
Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
2013 StandoutNobel
An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma
2011
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
2012
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
2003 StandoutNobel
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
A wide repertoire of miRNA binding sites: prediction and functional implications
2011
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
2004
Ago HITS-CLIP Expands Understanding of Kaposi's Sarcoma-associated Herpesvirus miRNA Function in Primary Effusion Lymphomas
2012
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome
2015
2013
An Epidermal MicroRNA Regulates Neuronal Migration Through Control of the Cellular Glycosylation State
2013 Science
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism
2004
Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets
2015
Predicting effective microRNA target sites in mammalian mRNAs
2015 Standout
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2
2006 StandoutNobel
Competitive Regulation of Nucleolin Expression by HuR and miR-494
2011
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
Demystifying the nuclear function of Argonaute proteins
2014
Structural basis for microRNA targeting
2014 Science
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3′UTRs
2010
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
2015
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
2015
Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions
2012
Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress
2016
Cyclic di-nucleotide signaling enters the eukaryote domain
2013
Enriching s4U‐RNA Using Methane Thiosulfonate (MTS) Chemistry
2016
Learning to Predict miRNA-mRNA Interactions from AGO CLIP Sequencing and CLASH Data
2016
The Hedgehog Signaling Pathway in Cancer
2006
Methods for comprehensive experimental identification of RNA-protein interactions
2014
The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β during Chlamydia trachomatis Infection
2014
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
2013 Science
Works of Manuel Ascano being referenced
FMRP targets distinct mRNA sequence elements to regulate protein expression
2012 Nature
Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability
2011
PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins
2010
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
2013
PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation)
2014
The Kinesin-related Protein Costal2 Associates with Membranes in a Hedgehog-sensitive, Smoothened-independent Manner
2004
Multi-disciplinary methods to define RNA–protein interactions and regulatory networks
2013
Viral crosslinking and solid-phase purification enables discovery of ribonucleoprotein complexes on incoming RNA virus genomes
2020
Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2
2003
Multimeric assembly and biochemical characterization of the Trax–translin endonuclease complex
2011
Identification of RNA–protein interaction networks using PAR‐CLIP
2011
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA
2014
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
2013
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
2019
Smoothened Regulates Activator and Repressor Functions of Hedgehog Signaling via Two Distinct Mechanisms
2006
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
2010 Standout
Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease
2014
Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity
2013
Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis
2019
PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins
2010
The Carboxyl-Terminal Domain of the Protein Kinase Fused Can Function as a Dominant Inhibitor of Hedgehog Signaling
2002