Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
2014
Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA
2014 Science
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
Transcriptomic portrait of human Mesenchymal Stromal/Stem cells isolated from bone marrow and placenta
2014
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
A genome editing approach to study cancer stem cells in human tumors
2017
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
2013 Standout
Tumor-targeting peptides from combinatorial libraries
2016
A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating γ-retroviral vectors using targeted integration
2009
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
2016 Nature
Pois(s)on – It's a Question of Dose…
2004
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
2015
Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free media
2007
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
2015
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
2014
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells
2017
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
2013
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations
2012
Metastatic Stem Cells: Sources, Niches, and Vital Pathways
2014
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
2015
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Genotoxicity of Retroviral Integration In Hematopoietic Cells
2006
Cancer stem cells revisited
2017 Standout
Upping the Ante: Recent Advances in Direct Reprogramming
2009
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
2016
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
2016 StandoutNobel
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
Clonal dynamics of native haematopoiesis
2014 Nature
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
2017 Nature
Meganucleases and DNA Double-Strand Break-Induced Recombination: Perspectives for Gene Therapy
2007
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
FLASH assembly of TALENs for high-throughput genome editing
2012
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
2013
Engineering targeted viral vectors for gene therapy
2007
A New Generation of Retroviral Producer Cells: Predictable and Stable Virus Production by Flp-Mediated Site-Specific Integration of Retroviral Vectors
2006
Alpharetroviral Vector-mediated Gene Therapy for X-CGD: Functional Correction and Lack of Aberrant Splicing
2012
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Progress and problems with the use of viral vectors for gene therapy
2003 Standout
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
1997 StandoutNobel
Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
2011
Targeted genome editing in human repopulating haematopoietic stem cells
2014 Nature
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
A Fresh Look at iPS Cells
2009 StandoutNobel
Molecular–functional imaging of cancer: to image and imagine
2007
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
2014 Standout
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
2007
Reducing mobilization of simian immunodeficiency virus based vectors by primer complementation
2004
Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases
2016
Reduced Genotoxicity of Avian Sarcoma Leukosis Virus Vectors in Rhesus Long-term Repopulating Cells Compared to Standard Murine Retrovirus Vectors
2008
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
2014
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Retrovirus Silencing, Variegation, Extinction, and Memory Are Controlled by a Dynamic Interplay of Multiple Epigenetic Modifications
2004
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors
2009 Standout
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
2013
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes
2016 StandoutNobel
The Human Condition—A Molecular Approach
2014 StandoutNobel
The Molecular Architecture of Odor and Pheromone Sensing in Mammals
2000 StandoutNobel
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
2018
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
2014
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
2015
Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?
2016
Genome Editing B.C. (Before CRISPR): Lasting Lessons from the “Old Testament”
2018
Transduction of Rhesus Macaque Hematopoietic Stem and Progenitor Cells with Avian Sarcoma and Leukosis Virus Vectors
2007
Adoptive Immunotherapy for Cancer or Viruses
2014
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells
2006
GT-Scan: identifying unique genomic targets
2014
Clues from cell metabolism
2010 StandoutNatureNobel
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
2016
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell–immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype
2007
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Fibroblast-Derived Induced Pluripotent Stem Cells Show No Common Retroviral Vector Insertions
2008
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus–based lentiviral vector system
2004
In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of β-thalassemia
2008
Self-Inactivating Alpharetroviral Vectors with a Split-Packaging Design
2010
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Modeling hepatitis C virus infection using human induced pluripotent stem cells
2012 StandoutNobel
Atraumatic Oral Spray Immunization with Replication-Deficient Viral Vector Vaccines
2007 StandoutNobel
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Delivery technologies for genome editing
2017
MECHANISMS OF OLFACTORY DISCRIMINATION: Converging Evidence for Common Principles Across Phyla
1997
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
2019
Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6
2017
Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs
2014
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Target specificity of the CRISPR‐Cas9 system
2014
Combinatorial Peptide Libraries: Mining for Cell-Binding Peptides
2013
Genome-Wide Analysis of Alpharetroviral Integration in Human Hematopoietic Stem/Progenitor Cells
2014
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
HEK293-Based Production Platform for γ-Retroviral (Self-Inactivating) Vectors: Application for Safe and Efficient Transfer ofCOL7A1cDNA
2014
Gene Therapy
2019
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Manfred Schmidt being referenced
Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts
2017
Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity
2012
Long-Term Clinical and Molecular Follow-up of Large Animals Receiving Retrovirally Transduced Stem and Progenitor Cells: No Progression to Clonal Hematopoiesis or Leukemia
2004
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
2006
Polyclonal long-term repopulating stem cell clones in a primate model
2002
A Hybrid Vector for Ligand-Directed Tumor Targeting and Molecular Imaging
2006
Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing
2010
TALEN-based Gene Correction for Epidermolysis Bullosa
2013
Real-Time Definition of Non-Randomness in the Distribution of Genomic Events
2007
High-Definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte Infusion
2010
High-resolution insertion-site analysis by linear amplification–mediated PCR (LAM-PCR)
2007
The β-Globin Locus Control Region in Combination With the EF1α Short Promoter Allows Enhanced Lentiviral Vector-mediated Erythroid Gene Expression With Conserved Multilineage Activity
2012
Stem-Cell Gene Therapy for the Wiskott–Aldrich Syndrome
2010
Chance or necessity? Insertional Mutagenesis in Gene Therapy and Its Consequences
2004
Efficient Characterization of Retro‐, Lenti‐, and Foamyvector‐Transduced Cell Populations by High‐Accuracy Insertion Site Sequencing
2003
Stem cell clonality and genotoxicity in hematopoietic cells: Gene activation side effects should be avoidable
2004
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk
2011
Effective gene therapy with nonintegrating lentiviral vectors
2006
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
2004
Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells
2004
Integration profile of retroviral vector in gene therapy treated patients is cell‐specific according to gene expression and chromatin conformation of target cell
2010
Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In Vivo
2012
An unbiased genome-wide analysis of zinc-finger nuclease specificity
2011
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
2009
Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases
2011
Antennular projections to the midbrain of the spiny lobster. II. Sensory innervation of the olfactory lobe
1992
Induced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-derived Differences in DNA Methylation Profiles
2012
Self-inactivating MLV vectors have a reduced genotoxic profile in human epidermal keratinocytes
2013
Gene Therapy for Fanconi Anemia: One Step Closer to the Clinic
2012
Retroviral Vector Performance in Defined Chromosomal Loci of Modular Packaging Cell Lines
2010
Fanconi Anemia Gene Editing by the CRISPR/Cas9 System
2014
Comparison of Three Retroviral Vector Systems for Transduction of Nonobese Diabetic/Severe Combined Immunodeficiency Mice Repopulating Human CD34 + Cord Blood Cells
2003
Detection and Direct Genomic Sequencing of Multiple Rare Unknown Flanking DNA in Highly Complex Samples
2001
Vector Integration and Tumorigenesis
2014
Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection
2011
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
2006
Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells
2005
Bioinformatic Clonality Analysis of Next-Generation Sequencing-Derived Viral Vector Integration Sites
2012
Stable Long-Term Blood Formation by Stem Cells in Murine Steady-State Hematopoiesis
2012
Methylguanine methyltransferase–mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model
2003
Murine Leukemia Induced by Retroviral Gene Marking
2002 Science
Morphology of the Brain of Crayfish, Crabs, and Spiny Lobsters: A Common Nomenclature for Homologous Structures
1992
Hot spots of retroviral integration in human CD34+ hematopoietic cells
2007
Therapeutic gene causing lymphoma
2006 Nature