Citation Impact
Citing Papers
EDRF coordinates the behaviour of vascular resistance vessels
1987 Nature
The Croonian Lecture, 1993. The endothelium: maestro of the blood circulation
1994 Nobel
Stranger in a strange land: The pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries
1991
Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets
1987
1990
Neurotransmitter release regulated by nitric oxide in PC-12 cells and brain synaptosomes
1993
The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide
1987
A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip
1989
Biosynthesis of nitric oxide from l-arginine
1989
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
1988
A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease
2001
Endothelium-derived nitric oxide relaxes nonvascular smooth muscle
1989 StandoutNobel
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery
2002 Standout
Interleukin-1 β induces the production of an L-arginine-derived relaxing factor from cultured smooth muscle cells from rat aorta
1991
ENDOTHELIN: AN IMPORTANT FACTOR IN ACUTE RENAL FAILURE?
1988 StandoutNobel
Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells
1988
Targeted disruption of the neuronal nitric oxide synthase gene
1993 Standout
Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction
2006 Standout
Comparative pharmacology of EDRF and nitric oxide on vascular strips
1987
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
1994 StandoutNature
Platelet Activation and Atherothrombosis
2007 Standout
Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.
1994
Synergistic inhibition of platelet aggregation by endothelium derived relaxing factor and prostacyclin
1988
Potassium-free solution prevents the action but not the release of endothelium-derived relaxing factor
1988
Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension
1990 Standout
Maxi K+ channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells
1993
Structure and function of cGMP-dependent protein kinases
2005
Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator
1988
Mechanisms of action of lipoxygenase and cytochrome P‐450‐mono‐oxygenase inhibitors in blocking endothelium‐dependent vasodilatation
1988
Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine
1990
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
1988 StandoutNature
Secondary prevention with folic acid: effects on clinical outcomes
2003
Effects of Folate Treatment and Homocysteine Lowering on Resistance Vessel Reactivity in Atherosclerotic Subjects
2002
Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension
1993 Standout
Endothelium-derived relaxing factor
1988
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission
1992 StandoutNobel
Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4
1989
Concentrations of Choline-Containing Compounds and Betaine in Common Foods
2003
Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
1996 StandoutNobel
The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes
1992 Standout
Atherosclerosis
2000 StandoutNature
Endothelium-dependent and independent effects of garlic on rat aorta
1994
Endothelium‐dependent hyperpolarization of canine coronary smooth muscle
1988
Isoforms of nitric oxide synthase Characterization and purification from different cell types
1991 StandoutNobel
Homocysteine and atherosclerosis
1999
Vascular endothelial cells synthesize nitric oxide from L-arginine
1988 StandoutNature
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
2011 StandoutNature
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries
1990
Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets
1987
Selective inhibition by gossypol of endothelium‐dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery
1987
Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial
2003
EDRF generation and release from perfused bovine pulmonary artery and vein
1988 StandoutNobel
Endothelial modulation of coronary tone
1988
Molecular cardiology: New avenues for the diagnosis and treatment of cardiovascular disease
1989
Nitric oxide and arthritis
1993
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.
1992 StandoutNobel
Folates and Cardiovascular Disease
2002
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
2002 StandoutNobel
Mechanism of action of some inhibitors of endothelium-derived relaxing factor.
1986
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells
1986
Endothelium‐dependent inhibition of platelet aggregation
1986
Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.
1993
Species-dependent differences in the nature of endothelium-derived vascular relaxing factor
1984
Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries.
1986
Cyclic guanosine monophosphate as a mediator of vasodilation.
1986 StandoutNobel
Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome.
2005
Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats.
1987
Effect of lowering of homocysteine levels on inflammatory markers: a randomized controlled trial.
2005
Role of Endothelium in the Contractions Induced by Norepinephrine and Clonidine in Rat Aorta
1985
Pungent products from garlic activate the sensory ion channel TRPA1
2005 StandoutNobel
Long-Term Homocysteine-Lowering Treatment With Folic Acid Plus Pyridoxine Is Associated With Decreased Blood Pressure but Not With Improved Brachial Artery Endothelium-Dependent Vasodilation or Carotid Artery Stiffness
2001
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
1991 StandoutNobel
Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.
1989 StandoutNobel
Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates.
1986
Release and properties of endothelium‐derived relaxing factor (EDRF) from endothelial cells in culture
1985
Short- and long-term interactions of endothelium and vascular smooth muscle in coculture: effects on cyclic GMP production.
1986
Thyrotropin-Releasing Hormone
1982
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
1997 StandoutNobel
Role of endothelium-derived nitric oxide in the regulation of blood pressure.
1989 Standout
Endothelium-derived relaxing factor and coronary vasospasm.
1989
Endothelium-derived vascular relaxing factor.
1985
Thyroid Hormone Regulation of Metabolism
2014 Standout
Laser-induced endothelial damage inhibits endothelium-dependent relaxation in the cerebral microcirculation of the mouse.
1987
Nitric oxide: linking space and time in the brain.
1992 Nobel
Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis.
1989
Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.
1993 StandoutNobel
Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.
1996
Modulation of guanylate cyclase by lipoxygenase inhibitors.
1986
Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner
1998 StandoutNobel
Aortocoronary Saphenous Vein Graft Disease
1998 Standout
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
Mechanisms of endothelium-dependent vascular smooth muscle relaxation
1985
Modulation of Vascular Smooth Muscle Contraction by the Endothelium
1986
Ca2+ influx through stretch-activated cation channels activates maxi K+ channels in porcine endocardial endothelium.
1994
Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS
1994 StandoutScienceNobel
Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.
1994 StandoutNobel
Endothelium-dependent relaxation and experimental atherosclerosis in the rabbit aorta
1986
Endothelium-dependent relaxation of human epicardial coronary arteries: frequent lack of effect of acetylcholine
1986
Endothelium-derived nitric oxide synthase inhibition. Effects on cerebral blood flow, pial artery diameter, and vascular morphology in rats.
1992
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
1991 StandoutNobel
Endothelium‐dependent relaxation in coronary arteries requires magnesium ions
1987
Endothelium‐derived nitric oxide: actions and properties
1989 StandoutNobel
Activation of membrane guanylate cyclase by an invertebrate peptide hormone
1990
Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled.
1988 Nobel
Endothelium-dependent relaxation in experimental atherosclerosis in the rabbit.
1987
Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects
2004
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
1987 Standout
Endothelial cells in culture produce a vasoconstrictor substance
1987
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
1999 StandoutNobel
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
2016 Standout
Interactions of Endothelial Cells and Smooth Muscle Cells of Arteries
1985 StandoutNobel
New insights into the cellular mechanisms of vasospas
1985
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
1986 Standout
Existence of nitric oxide synthase in rat hippocampal pyramidal cells.
1994 StandoutNobel
Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.
1985
Endothelial dysfunction in patients with recent myocardial infarction and hyperhomocysteinaemia: effects of vitamin supplementation
2004
Characterization of vascular relaxant factor released from cultured endothelial cells.
1987
The discovery of nitric oxide as the endogenous nitrovasodilator.
1988
Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.
1995 StandoutNobel
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.
1987 StandoutNobel
The loss of endothelium-dependent vascular relaxation in hypertension.
1986
Thimerosal induces endothelium-dependent vascular smooth muscle relaxations by interacting with thiol groups
1986
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
1986 StandoutNature
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
1996 StandoutNobel
Crucial role of endothelium in the vasodilator response to increased flow in vivo.
1986
Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
1986
Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells.
1988 Nobel
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.
1991 StandoutNobel
Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells
1997
Extracellular ATP: effects, sources and fate
1986 Standout
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.
1990 StandoutNobel
Works of Malcolm Lewis being referenced
Lowering plasma homocysteine with folic acid in cardiovascular disease: what will the trials tell us?
2002
Nitric oxide synthase in cultured endocardial cells of the pig
1991
Surgical Preparation Impairs Release of Endothelium-Derived Relaxing Factor From Human Saphenous Vein
1989
NMDA-induced release of nitric oxide potentiates aspartate overflow from cerebellar slices
1992
Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage
2003
Action potential duration and endocardial modulation of myocardial contraction in the ferret
1992
Endothelium-derived relaxing factor
1988
Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia
2000
Modulation of myocardial contraction by endocardial and coronary vascular endothelium
1993
Release of Endothelium-Derived Relaxing Factor is Inhibited by 8-Bromo-Cyclic Guanosine Monophosphate
1988
Evidence that inhibitory factor extracted from bovine retractor penis is nitrite, whose acid‐activated derivative is stabilized nitric oxide
1988
A comparison of basal and agonist‐stimulated release of endothelium‐derived relaxing factor from different arteries
1989
In vivo EDRF activity influences platelet function
1988
Endothelium Derived Relaxant Factor
1985
Factors released from endocardium of the ferret and pig modulate myocardial contraction.
1991
Influence of endothelium on drug-induced relaxation of the rabbit aorta
1986
Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation
1985
Ciprofibrate Therapy Improves Endothelial Function and Reduces Postprandial Lipemia and Oxidative Stress in Type 2 Diabetes Mellitus
2000
Isolated perfused rabbit coronary artery and aortic strip preparations: the role of endothelium‐derived relaxant factor.
1984
Folic Acid Improves Endothelial Function in Coronary Artery Disease via Mechanisms Largely Independent of Homocysteine Lowering
2002
A phorbol ester inhibits the release of endothelium-derived relaxing factor
1987
Hyperhomocysteinemia After an Oral Methionine Load Acutely Impairs Endothelial Function in Healthy Adults
1998
Endothelium‐derived relaxing factor inhibits the formation of inositol trisphosphate by rabbit aorta.
1989
DOPAMINE IS A PHYSIOLOGICAL REGULATOR OF THYROTROPHIN (TSH) SECRETION IN NORMAL MAN
1979
The relationship between inhibitory factor, EDRF, nitrite and nitric oxide
1987
Modulation of left ventricular relaxation in isolated ejecting heart by endogenous nitric oxide
1994
Endothelium‐derived relaxing factor inhibitsin vitroplatelet aggregation
1987
Folate Improves Endothelial Function in Coronary Artery Disease
2001
In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets
2005
The nature of endothelium-derived vascular relaxant factor
1984 Nature
Endothelium‐derived relaxing factor alters calcium fluxes in rabbit aorta: a cyclic guanosine monophosphate‐mediated effect.
1986