Standout Papers
- Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide‐bond formation, chirality discrimination and antibiotics synergism (2004)
- Functional aspects of ribosomal architecture: symmetry, chirality and regulation (2004)
- Antibiotics Targeting Ribosomes: Crystallographic Studies (2002)
- Ribosomal crystallography: Peptide bond formation and its inhibition (2003)
- Structural Basis of the Ribosomal Machinery for Peptide Bond Formation, Translocation, and Nascent Chain Progression (2003)
- On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes (2003)
Citation Impact
Citing Papers
Rχ-01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid Resistance
2008
Rapid peptide bond formation on isolated 50S ribosomal subunits
2006
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70 S Ribosome
2009 StandoutScienceNobel
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity
2007 StandoutNobel
Simulating movement of tRNA into the ribosome during decoding
2005
Structure of the 70 S Ribosome Complexed with mRNA and tRNA
2006 StandoutScienceNobel
Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome
2008 StandoutScienceNobel
Structures of the Bacterial Ribosome at 3.5 A Resolution
2005 Science
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin
2004 StandoutNobel
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Mutation from guanine to adenine in 25S rRNA at the position equivalent to E. coli A2058 does not confer erythromycin sensitivity in Sacchromyces cerevisae
2008
Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance
2005 StandoutNobel
Solution Structure of Ribosomal Protein L16 from Thermus thermophilus HB8
2004
The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation
2003
Definition of bases in 23S rRNA essential for ribosomal subunit association
2004
Hibernating Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)
2010 Nobel
Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451
2005
Essential Mechanisms in the Catalysis of Peptide Bond Formation on the Ribosome
2005
Contribution of 16S rRNA nucleotides forming the 30S subunit A and P sites to translation inEscherichia coli
2005
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Peptide bond formation on the ribosome: structure and mechanism
2003
Chaperone Binding at the Ribosomal Exit Tunnel
2003
Peptide bond formation does not involve acid-base catalysis by ribosomal residues
2006
The Geometry of the Ribosomal Polypeptide Exit Tunnel
2006 StandoutNobel
The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole
2007 StandoutNobel
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome
2009 StandoutNobel
Structural Insights into the Roles of Water and the 2′ Hydroxyl of the P Site tRNA in the Peptidyl Transferase Reaction
2005 StandoutNobel
From peptide‐bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects
2004 StandoutNobel
Correlating ribosome function with high-resolution structures
2008 StandoutNobel
Structure of the E. coli protein-conducting channel bound to a translating ribosome
2005 StandoutNatureNobel
How ribosomes make peptide bonds
2006
An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination
2007
X‐ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit
2004
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
A crevice adjoining the ribosome tunnel: Hints for cotranslational folding
2005 StandoutNobel
Symmetry at the active site of the ribosome: structural and functional implications
2005 StandoutNobel
Ribosomal Tolerance and Peptide Bond Formation
2003 StandoutNobel
Ribosomal antibiotics: structural basis for resistance, synergism and selectivity
2004 StandoutNobel
The Role of 23S Ribosomal RNA Residue A2451 in Peptide Bond Synthesis Revealed by Atomic Mutagenesis
2008
Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu
2009 StandoutNobel
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
2005 StandoutNatureNobel
Deletion of a Conserved, Central Ribosomal Intersubunit RNA Bridge
2006
A D-amino acid editing module coupled to the translational apparatus in archaea
2005
Mechanism of peptide bond formation on the ribosome
2006
Number, position, and significance of the pseudouridines in the large subunit ribosomal RNA of Haloarcula marismortui and Deinococcus radiodurans
2005
Ribosome crystallography: catalysis and evolution of peptide-bond formation, nascent chain elongation and its co-translational folding
2005 StandoutNobel
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit
2008 StandoutNobel
Ribosomal Crystallography: Peptide Bond Formation, Chaperone Assistance, and Antibiotics Inactivation
2007 StandoutNobel
Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center
2006 StandoutNobel
23S rRNA base pair 2057–2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A→G
2005 StandoutNobel
Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling
2009 StandoutScienceNobel
Structural characterization of mRNA-tRNA translocation intermediates
2012 StandoutNobel
Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome
2011 StandoutNobel
Inhibitors of protein biosynthesis
2006
RNA-peptide fusions for the in vitro selection of peptides and proteins
1997 StandoutNobel
The transition state for formation of the peptide bond in the ribosome
2006 StandoutNobel
Chemical parameters influencing fine-tuning in the binding of macrolide antibiotics to the ribosomal tunnel
2007 StandoutNobel
Initiation of Protein Synthesis in Bacteria
2005
Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin
2004 StandoutNobel
Antibiotics acting on the translational machinery
2003 StandoutNobel
How Should We Think About the Ribosome?
2012
Mechanism of peptide bond synthesis on the ribosome
2005
Trajectories of the ribosome as a Brownian nanomachine
2014 StandoutNobel
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
2009 StandoutScienceNobel
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Transfer RNA in the hybrid P/E state: Correlating molecular dynamics simulations with cryo-EM data
2007 StandoutNobel
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
Structural basis for cross-resistance to ribosomal PTC antibiotics
2008 StandoutNobel
The ribosome revealed
2005 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Efficient Ribosomal Peptidyl Transfer Critically Relies on the Presence of the Ribose 2‘-OH at A2451 of 23S rRNA
2006
Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation
2011 StandoutNobel
ANTIBIOTICS TARGETING RIBOSOMES: Resistance, Selectivity, Synergism, and Cellular Regulation
2005 StandoutNobel
The process of mRNA–tRNA translocation
2007 StandoutNobel
What Are the Roles of Substrate-Assisted Catalysis and Proximity Effects in Peptide Bond Formation by the Ribosome?
2005 StandoutNobel
Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit
2016 StandoutNobel
Simulating the pulling of stalled elongated peptide from the ribosome by the translocon
2013 StandoutNobel
Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action
2005 StandoutNobel
Ribosomal Crystallography: Initiation, Peptide Bond Formation, and Amino Acid Polymerization are Hampered by Antibiotics
2004 StandoutNobel
Ribosomal Features Essential for tna Operon Induction: Tryptophan Binding at the Peptidyl Transferase Center
2007
Works of Maggie Kessler being referenced
On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes
2003 StandoutNobel
Ribosomal crystallography: Peptide bond formation and its inhibition
2003 StandoutNobel
Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide‐bond formation, chirality discrimination and antibiotics synergism
2004 StandoutNobel
Antibiotics Targeting Ribosomes: Crystallographic Studies
2002 StandoutNobel
Structural Basis of the Ribosomal Machinery for Peptide Bond Formation, Translocation, and Nascent Chain Progression
2003 StandoutNobel
Functional aspects of ribosomal architecture: symmetry, chirality and regulation
2004 StandoutNobel