Standout Papers
- Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit (2007)
- The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State (2009)
- Structure of the 70 S Ribosome Complexed with mRNA and tRNA (2006)
- Crystal structure of the ribosome recycling factor bound to the ribosome (2007)
- Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon (2005)
Citation Impact
Citing Papers
Rχ-01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid Resistance
2008
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Crystal Structure of the Eukaryotic 40 S Ribosomal Subunit in Complex with Initiation Factor 1
2010 Science
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70 S Ribosome
2009 StandoutScienceNobel
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity
2007 StandoutNobel
Structure of the Yeast Mitochondrial Large Ribosomal Subunit
2014 ScienceNobel
Crystal Structure of the Eukaryotic Ribosome
2010 Science
Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome
2008 StandoutScienceNobel
Structures of the Bacterial Ribosome at 3.5 A Resolution
2005 Science
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes
2008
RELION: Implementation of a Bayesian approach to cryo-EM structure determination
2012 Standout
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
The Structure and Function of the Eukaryotic Ribosome
2012
The ribosome in focus: new structures bring new insights
2007
Elongation Factor G Participates in Ribosome Disassembly by Interacting with Ribosome Recycling Factor at Their tRNA-Mimicry Domains
2002
mRNA translocation occurs during the second step of ribosomal intersubunit rotation
2011
A sequence element that tunes Escherichia coli tRNAAlaGGC to ensure accurate decoding
2009
Sequence of Steps in Ribosome Recycling as Defined by Kinetic Analysis
2005
Long-Residency Hydration, Cation Binding, and Dynamics of Loop E/Helix IV rRNA-L25 Protein Complex
2004
Atomic structures of the eukaryotic ribosome
2012
Interactions of the Release Factor RF1 with the Ribosome as Revealed by Cryo-EM
2006 StandoutNobel
Crosslinking of Translation Factor EF-G to Proteins of the Bacterial Ribosome Before and After Translocation
2007
Kinetically Competent Intermediates in the Translocation Step of Protein Synthesis
2007
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
The Spliceosome: Design Principles of a Dynamic RNP Machine
2009 Standout
The Ribosomal Peptidyl Transferase
2007
High Resolution Structure of the Large Ribosomal Subunit from a Mesophilic Eubacterium
2001 StandoutNobel
Structural basis for aminoglycoside inhibition of bacterial ribosome recycling
2007
Mechanism for the Disassembly of the Posttermination Complex Inferred from Cryo-EM Studies
2005 StandoutNobel
A structural view of translation initiation in bacteria
2008
Post-termination complex disassembly by ribosome recycling factor, a functional tRNA mimic
2002
Phylogenetic distribution of translational GTPases in bacteria
2007
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
2009 Standout
Orientation of Ribosome Recycling Factor in the Ribosome from Directed Hydroxyl Radical Probing
2002
Ribosomal RNAs are tolerant toward genetic insertions: evolutionary origin of the expansion segments
2008
Coupling of Ribosomal L1 Stalk and tRNA Dynamics during Translation Elongation
2008
A Model for How Ribosomal Release Factors Induce Peptidyl-tRNA Cleavage in Termination of Protein Synthesis
2007
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
GTPase activation of elongation factor EF‐Tu by the ribosome during decoding
2009 StandoutNobel
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
A hierarchical model for evolution of 23S ribosomal RNA
2009 Nature
A fast dynamic mode of the EF‐G‐bound ribosome
2009
Molecular dynamics of EF‐G during translocation
2011 StandoutNobel
A short history ofSHELX
2007 Standout
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
2008
Hinge-Like Motions in RNA Kink-Turns: The Role of the Second A-Minor Motif and Nominally Unpaired Bases
2005
Splitting of the Posttermination Ribosome into Subunits by the Concerted Action of RRF and EF-G
2005
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)
2013 StandoutNobel
Structural insights into cognate versus near‐cognate discrimination during decoding
2011 StandoutNobel
The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole
2007 StandoutNobel
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome
2009 StandoutNobel
Binding of Ribosome Recycling Factor to Ribosomes, Comparison with tRNA
2002
Viral IRES RNA structures and ribosome interactions
2008
Specific interaction between the ribosome recycling factor and the elongation factor G from Mycobacterium tuberculosis mediates peptidyl-tRNA release and ribosome recycling in Escherichia coli
2001
Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy
2010 Nature
On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes
2003 StandoutNobel
Structure and Binding Mode of a Ribosome Recycling Factor (RRF) from Mesophilic Bacterium
2003
A structural understanding of the dynamic ribosome machine
2008 StandoutNobel
Structure and Dynamics of the Mammalian Ribosomal Pretranslocation Complex
2011
Structures of the human and Drosophila 80S ribosome
2013 Nature
Evolution of Elongation Factor G and the Origins of Mitochondrial and Chloroplast Forms
2010
Correlating ribosome function with high-resolution structures
2008 StandoutNobel
Release Factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies
2007
Interaction of RRF and EF-G from E. coli and T. thermophilus with ribosomes from both origins—insight into the mechanism of the ribosome recycling step
2005
Aminoglycoside activity observed on single pre-translocation ribosome complexes
2009
Structural dynamics of the ribosome
2008
Navigating the ribosome's metastable energy landscape
2009
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Symmetric K+ and Mg2+ Ion-binding Sites in the 5S rRNA Loop E Inferred from Molecular Dynamics Simulations
2003
Structural rearrangements of the ribosome at the tRNA proofreading step
2010
X-ray Structural Studies of Mycobacterium tuberculosis RRF and a Comparative Study of RRFs of Known Structure. Molecular Plasticity and Biological Implications
2004
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site 1 1Edited by I. A. Wilson
2000
Structure of the ternary initiation complex aIF2–GDPNP–methionylated initiator tRNA
2012
Single-Molecule Fluorescence Measurements of Ribosomal Translocation Dynamics
2011
Crystal structure combined with genetic analysis of the Thermus thermophilus ribosome recycling factor shows that a flexible hinge may act as a functional switch
2000
Assembly and Analysis of Eukaryotic Translation Initiation Complexes
2007
Functional sites of interaction between release factor RF1 and the ribosome.
2000
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Making sense of mimic in translation termination
2003
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNAMet and AUG selection
2008
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Observation of Intersubunit Movement of the Ribosome in Solution Using FRET
2007
A short guide for molecular dynamics simulations of RNA systems
2008
An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination
2007
Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics
2008 StandoutNobel
X‐ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit
2004
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Crystal structure of archaeal toxin-antitoxin RelE–RelB complex with implications for toxin activity and antitoxin effects
2005
Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome
2008 StandoutNobel
Bacterial Polypeptide Release Factor RF2 Is Structurally Distinct from Eukaryotic eRF1
2001
Identification of Two Distinct Hybrid State Intermediates on the Ribosome
2007
Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements
2006
Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM
2009 StandoutNobel
Peptide‐Bond Synthesis on the Ribosome: No Free Vicinal Hydroxy Group Required on the Terminal Ribose Residue of Peptidyl‐tRNA
2008
Ribosome recycling factor disassembles the post‐termination ribosomal complex independent of the ribosomal translocase activity of elongation factor G
2004
Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod‐Debye law
2011
Spontaneous Intersubunit Rotation in Single Ribosomes
2008
Spontaneous reverse movement of mRNA-bound tRNA through the ribosome
2007
The Role of L1 Stalk–tRNA Interaction in the Ribosome Elongation Cycle
2010
Heterogeneity of Large Macromolecular Complexes Revealed by 3D Cryo-EM Variance Analysis
2008
Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites
2010 Nature
Substructure solution withSHELXD
2002 Standout
Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu
2009 StandoutNobel
Crystal Structure of Human eIF3k, the First Structure of eIF3 Subunits
2004
Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling
2009
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
2005 StandoutNatureNobel
Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation
2004 StandoutNobel
Release of Ribosome-bound Ribosome Recycling Factor by Elongation Factor G
2003
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Structural basis for messenger RNA movement on the ribosome
2006 Nature
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
Correlated conformational events in EF-G and the ribosome regulate translocation
2010
Deletion of a Conserved, Central Ribosomal Intersubunit RNA Bridge
2006
The Fourth Step of Protein Synthesis: Disassembly of the Posttermination Complex Is Catalyzed by Elongation Factor G and Ribosome Recycling Factor, a Near-perfect Mimic of tRNA
2001
Conformations of Flanking Bases in HIV-1 RNA DIS Kissing Complexes Studied by Molecular Dynamics
2007
Two Distinct Components of Release Factor Function Uncovered by Nucleophile Partitioning Analysis
2007
The Roles of Ribosomal Proteins in the Structure Assembly, and Evolution of the Large Ribosomal Subunit
2004 StandoutNobel
Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit
2003 StandoutNobel
Structure of the 30S translation initiation complex
2008 Nature
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
2001 StandoutNatureNobel
Translational termination comes of age
2000
Following translation by single ribosomes one codon at a time
2008 Nature
The antibiotic viomycin traps the ribosome in an intermediate state of translocation
2007
Structural basis for translation termination on the 70S ribosome
2008 Nature
tRNA–mRNA mimicry drives translation initiation from a viral IRES
2007
Elastic properties of ribosomal RNA building blocks: molecular dynamics of the GTPase-associated center rRNA
2007
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit
2008 StandoutNobel
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-Å resolution
2010
Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center
2006 StandoutNobel
Structures of the Ribosome in Intermediate States of Ratcheting
2009 Science
Structural characterization of mRNA-tRNA translocation intermediates
2012 StandoutNobel
A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome
2008
Integrity of the P-site is probed during maturation of the 60S ribosomal subunit
2012 StandoutNobel
Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding
2011 Science
Spontaneous formation of the unlocked state of the ribosome is a multistep process
2009
Crystal structure of a translation termination complex formed with release factor RF2
2008
Interactions and dynamics of the Shine–Dalgarno helix in the 70S ribosome
2007
Crystal structure of elongation factor P from Thermus thermophilus HB8
2004
Ribosomal Translocation: One Step Closer to the Molecular Mechanism
2009
The Mechanism for Activation of GTP Hydrolysis on the Ribosome
2010 ScienceNobel
Peptide Release on the Ribosome: Mechanism and Implications for Translational Control
2008
Structural basis for TetM-mediated tetracycline resistance
2012
Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
2013
Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3
2011 Nobel
Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: Functional implications
2004 StandoutNobel
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Irreversible chemical steps control intersubunit dynamics during translation
2008
Transfer RNA in the hybrid P/E state: Correlating molecular dynamics simulations with cryo-EM data
2007 StandoutNobel
Structural basis for cross-resistance to ribosomal PTC antibiotics
2008 StandoutNobel
Crystal Structure of the Eukaryotic 60 S Ribosomal Subunit in Complex with Initiation Factor 6
2011 Science
Following movement of the L1 stalk between three functional states in single ribosomes
2009
X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli
2003
The ribosome and the mechanism of protein synthesis
2006 StandoutNobel
Role of Ribosomal Protein L27 in Peptidyl Transfer
2008
Heterologous expression of Aquifex aeolicus ribosome recycling factor in Escherichia coli is dominant lethal by forming a complex that lacks functional co‐ordination for ribosome disassembly
2004
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome
2010
The process of mRNA–tRNA translocation
2007 StandoutNobel
Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination
2007
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
2008
Translation at the Single-Molecule Level
2008
Characterization of Mycobacterium tuberculosis ribosome recycling factor (RRF) and a mutant lacking six amino acids from the C-terminal end reveals that the C-terminal residues are important for its occupancy on the ribosome
2002
Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit
2008 StandoutNobel
Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistantStaphylococcus aureusresistant to the synthetic antibiotic linezolid
2007
Fidelity at the Molecular Level: Lessons from Protein Synthesis
2009
Stop Codon Recognition by Release Factors Induces Structural Rearrangement of the Ribosomal Decoding Center that Is Productive for Peptide Release
2007
Allosteric collaboration between elongation factor G and the ribosomal L1 stalk directs tRNA movements during translation
2009
Works of M. Selmer being referenced
Structure of the 70 S Ribosome Complexed with mRNA and tRNA
2006 StandoutScienceNobel
Is tRNA Binding or tRNA Mimicry Mandatory for Translation Factors?
2002
Structure of ribosomal protein TL5 complexed with RNA provides new insights into the CTC family of stress proteins
2001
Crystal structure of an mRNA-binding fragment of Moorella thermoacetica elongation factor SelB
2002
Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit
2007 StandoutNobel
Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon
2005 StandoutNobel
Crystal structure of the ribosome recycling factor bound to the ribosome
2007 StandoutNobel
Structure of the L1 protuberance in the ribosome
2003
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
2009 StandoutScienceNobel
Crystal Structure of Thermotoga maritima Ribosome Recycling Factor: A tRNA Mimic
1999 Science