Citation Impact
Citing Papers
Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay
2010 Science
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Negative regulation of the weel protein kinase by direct action of the nim1/cdr1 mitotic inducer
1993
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
The genome of the offspring of a Neanderthal mother and a Denisovan father
2018 StandoutNatureNobel
The stretch of C-terminal acidic amino acids of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast
1998
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
The invariant uridine of stop codons contacts the conserved NIKSR loop of human eRF1 in the ribosome
2002
Terminating eukaryote translation: Domain 1 of release factor eRF1 functions in stop codon recognition
2000
A cyclin associated with the CDK-activating kinase MO15
1994 Nature
Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes
1991
In Vitro Reconstitution of Eukaryotic Translation Reveals Cooperativity between Release Factors eRF1 and eRF3
2006
Structural aspects of translation termination on the ribosome
2011
The decision to enter mitosis
1994
Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast
1991
Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis
1998
Isolation and characterization of goldfish cdk2, a cognate variant of the cell cycle regulator cdc2
1992
Identification of eRF1 residues that play critical and complementary roles in stop codon recognition
2012
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
1992
The Crystal Structure of Human Eukaryotic Release Factor eRF1—Mechanism of Stop Codon Recognition and Peptidyl-tRNA Hydrolysis
2000
Population explosion in the cyclin family
1991
Highly conserved NIKS tetrapeptide is functionally essential in eukaryotic translation termination factor eRF1
2002
A mitochondrial genome sequence of a hominin from Sima de los Huesos
2013 StandoutNatureNobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system
1991
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins
1991
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase
1993
Termination of translation in eukaryotes is mediated by the quaternary eRF1•eRF3•GTP•Mg2+ complex. The biological roles of eRF3 and prokaryotic RF3 are profoundly distinct
2006
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
1991
Cyclins and cancer
1991
Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
1992
The cdc25 protein contains an intrinsic phosphatase activity
1991
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Cyclin a is required for the onset of DNA replication in mammalian fibroblasts
1991
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
1993 Standout
Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
2013 StandoutNobel
Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3
2006
The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts
1996
Crystal Structure and Functional Analysis of the Eukaryotic Class II Release Factor eRF3 from S. pombe
2004
Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI+], a Heritable Prion-like Factor of S. cerevisiae
1997
Evolution of nonstop, no-go and nonsense-mediated mRNA decay and their termination factor-derived components
2008
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase
1991 Nature
Structural and Functional Insights into Dom34, a Key Component of No-Go mRNA Decay
2007
Role for cyclin A in the dependence of mitosis on completion of DMA replication
1991 Nature
Isolation, characterisation and molecular cloning of new mutant alleles of the fission yeast p34 cdc2+ protein kinase gene: identification of temperature-sensitive G2-arresting alleles
1991 StandoutNobel
Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis
1999
Structural basis for translation termination by archaeal RF1 and GTP-bound EF1α complex
2012
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Two-step model of stop codon recognition by eukaryotic release factor eRF1
2013
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
An early modern human from Romania with a recent Neanderthal ancestor
2015 StandoutNatureNobel
INH, a negative regulator of MPF, is a form of protein phosphatase 2A
1991
Structure of the Dom34–Hbs1 complex and implications for no-go decay
2010
Principles of CDK regulation
1995 StandoutNature
Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle
1991
Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosome binding but not for stop codon recognition
2001
Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins
2016 StandoutNatureNobel
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
1991
twine, a cdc25 homolog that functions in the male and female germline of drosophila
1992 StandoutNobel
Cyclin is degraded by the ubiquitin pathway
1991 StandoutNature
Role of the individual domains of translation termination factor eRF1 in GTP binding to eRF3
2007
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
Activation of p34cdc2 kinase by cyclin is negatively regulated by cyclic Amp-dependent protein kinase in Xenopus oocytes
1992
Structural insights into eRF3 and stop codon recognition by eRF1
2009
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
2005 StandoutNatureNobel
Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2
1992
Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes
2011
A Posttermination Ribosomal Complex Is the Guanine Nucleotide Exchange Factor for Peptide Release Factor RF3
2001
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
1999
Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus
1996
Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
1994
Cut2 proteolysis required for sister-chromatid separation in fission yeast
1996 StandoutNatureNobel
Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs
1991 StandoutNatureNobel
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Structure of the no-go mRNA decay complex Dom34–Hbs1 bound to a stalled 80S ribosome
2011
Translational termination comes of age
2000
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
1991
In vitro selection and evolution of proteins
2001
Mammalian G1 cyclins
1993 Standout
Kinetic Analysis of Interaction of Eukaryotic Release Factor 3 with Guanine Nucleotides
2006
Termination and post-termination events in eukaryotic translation
2012
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.
1991
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.
1992
A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.
1995 StandoutNobel
Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.
1994
Phosphorylation of Xenopus Cyclins B1 and B2 Is Not Required for Cell Cycle Transitions
1991
Requirement of mosXe Protein Kinase for Meiotic Maturation of Xenopus Oocytes Induced by a cdc2 Mutant Lacking Regulatory Phosphorylation Sites
1992
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.
1993
Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.
1992
A Dominant Negative Allele of p34cdc2 Shows Altered Phosphoamino Acid Content and Sequesters p56cdc13 Cyclin
1992 StandoutNobel
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.
1992
Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells
1992
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro.
1993
Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.
1993
Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein.
1991
Mitotic arrest caused by the amino terminus of Xenopus cyclin B2.
1993
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
1993 StandoutNobel
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.
1993
Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.
1991
cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2.
1992
A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.
1996 StandoutNobel
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
Cloning of a D-type cyclin from murine erythroleukemia cells.
1992
cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.
1992
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.
1991
Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex
2010
Activation of Cyclin-Dependent Kinase 4 (cdk4) by Mouse MO15-Associated Kinase
1994
NMR solution structure and function of the C‐terminal domain of eukaryotic class 1 polypeptide chain release factor
2010
Cell cycle regulation of the p34cdc2 inhibitory kinases.
1994
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.
1993
Characterization of a germ-line proliferation mutation in C. elegans
1992
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.
1991
A family of human cdc2-related protein kinases.
1992
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.
1991 StandoutNobel
Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes.
1992
The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.
1993 StandoutNobel
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
1991
Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.
1995 StandoutNobel
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.
1993 StandoutNobel
An Inhibitor of p34 CDC28 Protein Kinase Activity from Saccharomyces cerevisiae
1993 Science
The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation.
1992
Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
1993
Three distinct DNA ligases in mammalian cells.
1991 StandoutNobel
Mitotic control
1991
THE DNA REPLICATION FORK IN EUKARYOTIC CELLS
1998
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.
1992
Multiple roles for protein phosphatase 1 in regulating the Xenopus early embryonic cell cycle.
1992
On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.
1991 StandoutNobel
A translational fidelity mutation in the universally conserved sarcin/ricin domain of 25S yeast ribosomal RNA.
1996
Phosphorylation of tau protein by purified p34cdc28 and a related protein kinase from neurofilaments.
1992
Cyclin-Dependent Regulation of G 1 in Mammalian Fibroblasts
1993 Science
Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.
1992
Ribosome Components Are Associated with Sites of Transcription
2002 StandoutNobel
Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.
1991
The cyclin‐dependent protein kinases and the control of cell division
1994
Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.
1993
Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210
1992
Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions.
1991
The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo.
1992 StandoutNobel
Raf-1 Protein Kinase Is Important for Progesterone-Induced Xenopus Oocyte Maturation and Acts Downstream of mos
1993
Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts.
1992
Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.
1992
Cyclin A is required at two points in the human cell cycle.
1992
Cyclin A and cyclin B dissociate from p34cdc2 with half-times of 4 and 15 h, respectively, regardless of the phase of the cell cycle.
1994 StandoutNobel
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
1989 StandoutScience
GTP Hydrolysis by eRF3 Facilitates Stop Codon Decoding during Eukaryotic Translation Termination
2004
Cyclin B targets p34cdc2 for tyrosine phosphorylation.
1991
Activation of the p34 CDC2 protein kinase at the start of S phase in the human cell cycle.
1992
cdc2 phosphorylation is required for its interaction with cyclin.
1991
Activation of human cyclin-dependent kinases in vitro.
1992
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
2001 StandoutScienceNobel
CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.
1993
Cryo-EM structure of the mammalian eukaryotic release factor eRF1–eRF3-associated termination complex
2012 StandoutNobel
Purification and characterization of a novel proline-directed protein kinase from bovine brain.
1992
Activation of p34cdc2 kinase by cyclin A.
1991
Two distinct mechanisms for negative regulation of the Wee1 protein kinase.
1993
Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments
2013 StandoutNobel
Chemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation.
1991
Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos.
1993
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.
1992
In Vitro Propagation of the Prion-Like State of Yeast Sup35 Protein
1997 Science
Mechanisms of p34cdc2 regulation.
1993
A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes.
1993
Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes
1993
Conserved motifs in prokaryotic and eukaryotic polypeptide release factors: tRNA-protein mimicry hypothesis.
1996
Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis
2000
Cell cycle regulation of a Xenopus Wee1-like kinase.
1995
Progression from meiosis I to meiosis II in Xenopus oocytes requires de novo translation of the mosxe protooncogene.
1991
Expression and activity of p40MO15, the catalytic subunit of cdk-activating kinase, during Xenopus oogenesis and embryogenesis.
1994
Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites.
1992
Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.
1995 StandoutNobel
Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β
1993 Science
INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS
1997
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.
1993
Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2.
1994
Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.
1993
Cell Cycle Tyrosine Phosphorylation of p34cdc2 and a Microtubule- Associated Protein Kinase Homolog in Xenopus Oocytes and Eggs
1991
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
1992
In vitro cell cycle arrest induced by using artificial DNA templates.
1992
Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.
1994 StandoutNobel
Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.
1991
Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.
1992 StandoutNobel
Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle.
1992
Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.
1992
Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.
1991 StandoutNobel
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
1994 Standout
Works of M. Philippe being referenced
The product of the mammalian orthologue of the Saccharomyces cerevisiaeHBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3‐like activity
1998
Cyclin activation of p34cdc2
1990
Identification of DNA ligase I related polypeptides in three different human cells
1990
Xenopus c‐raf proto‐oncogene: cloning and expression during oogenesis and early development
1991
Eukaryotic release factor 1 (eRF1) abolishes readthrough and competes with suppressor tRNAs at all three termination codons in messenger RNA
1997
Nucleotide sequence of Xenopus C-rafcoding region
1988
Deciphering the complete mitochondrial genome and phylogeny of the extinct cave bear in the Paleolithic painted cave of Chauvet
2008
Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2.
1992
Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts
1995
Eukaryotic polypeptide chain release factor eRF3 is an eRF1- and ribosome-dependent guanosine triphosphatase.
1996
Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.
1991
Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3.
1995
Early events in DNA replication require cyclin E and are blocked by p21CIP1.
1995
A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2.
1992