Standout Papers
- Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. (1995)
- Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. (1995)
Citation Impact
Citing Papers
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis.
1992
Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
2002
Effect of probucol on LDL oxidation and atherosclerosis in LDL receptor-deficient mice
1998
Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux
2005
Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
2004
Muscle Expression of Human Retinol-binding Protein (RBP)
2002
A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids
2001
Cholesterol efflux by acute-phase high density lipoprotein: role of lecithin:cholesterol acyltransferase
2001
Structural and functional diversity of paraoxonases
1996
Native and Modified Low Density Lipoproteins Increase the Functional Expression of the Macrophage Class B Scavenger Receptor, CD36
1997
Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro
2000
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
1998 StandoutNature
Atheroprotective mechanisms of HDL
1999
Rabbit Serum Paraoxonase 3 (PON3) Is a High Density Lipoprotein-associated Lactonase and Protects Low Density Lipoprotein against Oxidation
2000
A new antiinflammatory compound, leumedin, inhibits modification of low density lipoprotein and the resulting monocyte transmigration into the subendothelial space of cocultures of human aortic wall cells.
1993
The oxidation hypothesis of atherosclerosis
1994
Apo A-I inhibits foam cell formation in apo E–deficient mice after monocyte adherence to endothelium
1999
Role of oxidatively modified LDL in atherosclerosis
1990
Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH
1998
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
Prospects for Cardiovascular Research
2001 StandoutNobel
Lipoprotein Trafficking in Vascular Cells
1997
Paraoxonase-1 inhibits oxidised LDL-induced MCP-1 production by endothelial cells
2004
Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.
1992
Estrogen receptor α is a major mediator of 17β-estradiol’s atheroprotective effects on lesion size in Apoe–/– mice
2001 StandoutNobel
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
2003
Antioxidant treatment inhibits the development of intimal thickening after balloon injury of the aorta in hypercholesterolemic rabbits.
1993
Mechanisms of Disease: proatherogenic HDL—an evolving field
2006
The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70
1997 StandoutNobel
Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating β1 integrin
1999
High density associated enzymes: their role in vascular biology
1998
Paraoxonase Genes and Disease
1999
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
2009 Standout
Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.
1998
Minimally modified low density lipoprotein is biologically active in vivo in mice.
1991
Paraoxonase and coronary heart disease
1998
Nitric Oxide Inhibits Macrophage-Colony Stimulating Factor Gene Transcription in Vascular Endothelial Cells
1995
Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein.
1991
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
2002 Standout
Synthesis and secretion of macrophage colony stimulating factor by mature human monocytes and human monocytic THP-1 cells induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts
1996
Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.
1993
Some questions concerning a small, more electronegative LDL circulating in human plasma
1991
Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid–protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins
1999
Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.
1996
The Role of Oxidized Low-Density Lipoproteins in the Pathogenesis of Atherosclerosis
1992
Paraoxonase-2 Is a Ubiquitously Expressed Protein with Antioxidant Properties and Is Capable of Preventing Cell-mediated Oxidative Modification of Low Density Lipoprotein
2001
Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.
1996
Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
1999 Standout
Serum amyloid A, the major vertebrate acute‐phase reactant
1999
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis
1998 StandoutNature
Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells.
1995
Presence of paraoxonase in human interstitial fluid
1997
Tissue engineering a blood vessel: Regulation of vascular biology by mechanical stresses
1994
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.
1995
NF-κB: pivotal mediator or innocent bystander in atherogenesis?
2001
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Oxidized Phosphatidylcholines That Modify Proteins
1996
Role of the GRO family of chemokines in monocyte adhesion to MM-LDL-stimulated endothelium.
1994
Lack of effect of serum amyloid A (SAA) on the ability of high-density lipoproteins to inhibit endothelial cell adhesion molecule expression
2001
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
The immune response in atherosclerosis: a double-edged sword
2006 Standout
Structural Identification of a Novel Pro-inflammatory Epoxyisoprostane Phospholipid in Mildly Oxidized Low Density Lipoprotein
1999
Inflammation and cancer: back to Virchow?
2001 Standout
Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro.
1994
The transthyretin-retinol-binding protein complex
2000
Biochemistry of the Arterial Wall in Developing Atherosclerosisa
1991
Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.
1993
Oxidation of High Density Lipoproteins
1998
Atherosclerosis — An Inflammatory Disease
1999 Standout
Inflammation in atherosclerosis
2002 StandoutNature
Prelesional Modifications of the Vessel Wall in Hyperlipidemic Atherogenesis
1990
Origin and physiological roles of inflammation
2008 StandoutNature
Mechanism of Uptake of Copper-oxidized Low Density Lipoprotein in Macrophages Is Dependent on Its Extent of Oxidation
1996
Expression of heme oxygenase-1 can determine cardiac xenograft survival
1998
The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin
1996
High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions
2003
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
The Oxidation of Lipoproteins by Monocytes-Macrophages
1999
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.
1996
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
Low Density Lipoprotein Oxidation and Its Pathobiological Significance
1997
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
The role of oxidized lipoproteins in atherogenesis
1996
Oxidized phospholipids as modulators of inflammation in atherosclerosis
2003
The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes
1992 Standout
Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.
1997
Inflammation, Atherosclerosis, and Coronary Artery Disease
2005 Standout
Atherosclerosis
2000 StandoutNature
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
2008 Standout
Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo
1997
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
1997 StandoutNature
Acute-Phase Proteins and Other Systemic Responses to Inflammation
1999 Standout
Dietary copper supplementation reduces atherosclerosis in the cholesterol-fed rabbit
1999
C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
2000 Standout
Combined Serum Paraoxonase Knockout/Apolipoprotein E Knockout Mice Exhibit Increased Lipoprotein Oxidation and Atherosclerosis
2000 Standout
Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.
1994
Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.
1998 Standout
Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer
1998 StandoutNobel
Role of oxidized low density lipoprotein in atherogenesis.
1991 Standout
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
2002 StandoutNobel
Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes.
1997
Enhanced atherosclerosis and kidney dysfunction in eNOS–/–Apoe–/– mice are ameliorated by enalapril treatment
2000 StandoutNobel
Does paraoxonase play a role in susceptibility to cardiovascular disease?
1999
Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis
1998
The role of lipid peroxidation and antioxidants in oxidative modification of LDL
1992 Standout
Additional benefit of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemic men
1998
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein
1999
Human Serum Paraoxonase/Arylesterase’s Retained HydrophobicN-Terminal Leader Sequence Associates With HDLs by Binding Phospholipids
1999
Oxidized LDL enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes.
1994
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3
2000
Oxidants, antioxidants, and the degenerative diseases of aging.
1993 Standout
HDL, ABC Transporters, and Cholesterol Efflux: Implications for the Treatment of Atherosclerosis
2008
Minimally Oxidized Low-Density Lipoprotein Increases Expression of Scavenger Receptor A, CD36, and Macrosialin in Resident Mouse Peritoneal Macrophages
1998
Expression of heme oxygenase-1 in atherosclerotic lesions.
1998
Scavenger receptor-independent stimulation of cholesterol esterification in macrophages by low density lipoprotein extracted from human aortic intima.
1992
Human Paraoxonase-3 Is an HDL-Associated Enzyme With Biological Activity Similar to Paraoxonase-1 Protein but Is Not Regulated by Oxidized Lipids
2001
Paraoxonase Genotypes, Lipoprotein Lipase Activity, and HDL
1996
Oxidized low density lipoprotein inhibits the migration of aortic endothelial cells in vitro.
1993
Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice
2001 StandoutNobel
Interleukin-10 Blocks Atherosclerotic Events In Vitro and In Vivo
1999
High-Density Lipoprotein Loses Its Anti-Inflammatory Properties During Acute Influenza A Infection
2001
Protein kinase C inhibitors prevent impairment of endothelium-dependent relaxation by oxidatively modified LDL.
1993
Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis.
1995
Adenovirus-Mediated Heme Oxygenase-1 Gene Transfer Inhibits the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice
2001
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Relation of Vascular Oxidative Stress, α-Tocopherol, and Hypercholesterolemia to Early Atherosclerosis in Hamsters
1995
Decreased Protection by HDL From Poorly Controlled Type 2 Diabetic Subjects Against LDL Oxidation May Be Due to the Abnormal Composition of HDL
1999
Plasma and cellular retinoid-binding proteins and transthyretin (prealbumin) are all localized in the islets of Langerhans in the rat.
1985
Endothelial Responses to Oxidized Lipoproteins Determine Genetic Susceptibility to Atherosclerosis in Mice
2000
Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.
1991
High-Density Lipoproteins Differentially Modulate Cytokine-Induced Expression of E-Selectin and Cyclooxygenase-2
1999
Biphasic Regulation of Transcription Factor Nuclear Factor-κB Activity in Human Endothelial Cells by Lysophosphatidylcholine Through Protein Kinase C–Mediated Pathway
1998
Heme Oxygenase-1 Inhibits Atherogenesis in Watanabe Heritable Hyperlipidemic Rabbits
2001
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
2002 StandoutNobel
Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice.
1991
Atherosclerosis: Basic Mechanisms
1995 Standout
Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity
1999
Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.
1994
Functional Arteries Grown in Vitro
1999 StandoutScience
Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.
1990
Regulation of endothelial cell tissue factor expression by minimally oxidized LDL and lipopolysaccharide.
1993
Roles of Infectious Agents in Atherosclerosis and Restenosis
1997 Standout
HDL and the Inflammatory Response Induced by LDL-Derived Oxidized Phospholipids
2001
Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.
1994
Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.
1997
Why are low-density lipoproteins atherogenic?
1994
Macrophages, Endothelial Cells, and Lipoprotein Oxidation in the Pathogenesis of Atherosclerosis*
1990
Influenza Infection Promotes Macrophage Traffic Into Arteries of Mice That Is Prevented by D-4F, an Apolipoprotein A-I Mimetic Peptide
2002
Paraoxonase and Atherosclerosis
2001 Standout
Human Serum Paraoxonases (PON1) Q and R Selectively Decrease Lipid Peroxides in Human Coronary and Carotid Atherosclerotic Lesions
2000 Standout
Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase.
1995
Heme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice
2001
Cytokine regulation of endothelial cell function
1992
Role of Group II Secretory Phospholipase A 2 in Atherosclerosis
1999
The Yin and Yang of Oxidation in the Development of the Fatty Streak
1996 Standout
Induction of Macrophage VEGF in Response to Oxidized LDL and VEGF Accumulation in Human Atherosclerotic Lesions
1998
Role of Group II Secretory Phospholipase A2in Atherosclerosis
1999
Phospholipid composition of reconstituted high density lipoproteins influences their ability to inhibit endothelial cell adhesion molecule expression
2000
Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content.
1994
Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.
1991
Paraoxonase-Gene Polymorphisms Associated with Coronary Heart Disease: Support for the Oxidative Damage Hypothesis?
1998
HDL Remodeling During the Acute Phase Response
2008
Paraoxonase Active Site Required for Protection Against LDL Oxidation Involves Its Free Sulfhydryl Group and Is Different From That Required for Its Arylesterase/Paraoxonase Activities
1998
Determinants of Bioactivity of Oxidized Phospholipids
2000
Hypochlorite-Modified LDL: Chemotactic Potential and Chemokine Induction in Human Monocytes
1998
The Metabolic Syndrome, Circulating Oxidized LDL, and Risk of Myocardial Infarction in Well-Functioning Elderly People in the Health, Aging, and Body Composition Cohort
2004
Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL.
1992
Oxidative Stress and Vascular Disease
2004
The Response-to-Retention Hypothesis of Early Atherogenesis
1995
Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q→R genetic polymorphism
1999
Inflammatory/Antiinflammatory Properties of High-Density Lipoprotein Distinguish Patients From Control Subjects Better Than High-Density Lipoprotein Cholesterol Levels and Are Favorably Affected by Simvastatin Treatment
2003
Effect of Probucol Treatment on Gene Expression of VCAM-1, MCP-1, and M-CSF in the Aortic Wall of LDL Receptor–Deficient Rabbits During Early Atherogenesis
1997
Increased Immunolocalization of Paraoxonase, Clusterin, and Apolipoprotein A-I in the Human Artery Wall With the Progression of Atherosclerosis
1997
Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium.
1992
Serum Paraoxonase After Myocardial Infarction
1999
The Role of High-Density Lipoproteins in Oxidation and Inflammation
2001
Role of Monocytes in Atherogenesis
2003
Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans.
1992
The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells
2006
ESTROGENS AND ATHEROSCLEROSIS
1997
Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.
1994
Antiinflammatory Properties of HDL
2004 Standout
Lipoproteins and Atherogenesis
1990
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1
2000
Elevation of Plasma High-Density Lipoprotein Concentration Reduces Interleukin-1–Induced Expression of E-Selectin in an In Vivo Model of Acute Inflammation
2001
Monocytes may amplify their recruitment into inflammatory lesions by inducing monocyte chemotactic protein.
1992
Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits.
1991
Iron overload diminishes atherosclerosis in apoE-deficient mice
2001
Hypertension and the Pathogenesis of Atherosclerosis
1995
Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells.
1992
Works of M. Navab being referenced
Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.
1997
Interaction of monocytes with cocultures of human aortic wall cells involves interleukins 1 and 6 with marked increases in connexin43 message.
1991
Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.
1995 Standout
Monocyte adhesion and transmigration in atherosclerosis
1994
Lipoprotein oxidation and gene expression in the artery wall
1993
Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins
1990 Nature
Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures.
1995 Standout
Rat plasma prealbumin. Isolation and partial characterization.
1977
Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance.
1986
Rat plasma prealbumin. Metabolic studies on effects of vitamin A status and on tissue distribution.
1977