Citation Impact
Citing Papers
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
2002 Standout
Non-Identity-Mediated CRISPR-Bacteriophage Interaction Mediated via the Csy and Cas3 Proteins
2011
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
Genome sequence of an industrial microorganism Streptomyces avermitilis : Deducing the ability of producing secondary metabolites
2001 StandoutNobel
Rapid and automated design of two-component protein nanomaterials using ProteinMPNN
2024 StandoutNobel
Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
2005
HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
2014 StandoutNobel
Desaturases: Emerging Models for Understanding Functional Diversification of Diiron-containing Enzymes
2009
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
Coronavirus biology and replication: implications for SARS-CoV-2
2020 Standout
Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity
2004
Structural Insights into RNA Recognition by RIG-I
2011
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determinationElectronic supplementary information (ESI) available: LCMS spectra and detailed experimental procedures for all reported experiments. See http://www.rsc.org/suppdata/cc/b3/b300847a/
2003
Computational Approach for Prediction of Domain Organization and Substrate Specificity of Modular Polyketide Synthases
2003
Inhibition of Tumor-associated Fatty Acid Synthase Hyperactivity Induces Synergistic Chemosensitization of HER-2/neu-Overexpressing Human Breast Cancer Cells to Docetaxel (taxotere)
2004
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
2005 Standout
The chalcone synthase superfamily of type III polyketide synthases
2002
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria
2016
Central nervous system control of food intake and body weight
2006 StandoutNature
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
2007 Standout
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3
2015 StandoutNobel
A guide to immunometabolism for immunologists
2016 Standout
A Fatty Acid Synthase Blockade Induces Tumor Cell-cycle Arrest by Down-regulating Skp2
2004
Marine natural products
1990 Standout
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
2011 Standout
Evolutionarily Conserved Roles of the Dicer Helicase Domain in Regulating RNA Interference Processing
2014 StandoutNobel
Structural and functional organization of the animal fatty acid synthase
2003
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase
2003
Palladium(II)‐Catalyzed CH Activation/CC Cross‐Coupling Reactions: Versatility and Practicality
2009 Standout
Purification and Biochemical Characterization of theMycobacterium tuberculosis β-Ketoacyl-acyl Carrier Protein Synthases KasA and KasB
2001
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Sterol Regulatory Element-Binding Protein-1 Participates in the Regulation of Fatty Acid Synthase Expression in Colorectal Neoplasia
2000
Inhibiting Bacterial Fatty Acid Synthesis
2006
Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes
2013 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
Roles of the Active Site Water, Histidine 303, and Phenylalanine 396 in the Catalytic Mechanism of the Elongation Condensing Enzyme of Streptococcus pneumoniae
2006
Green Tea Epigallocatechin Gallate: A Natural Inhibitor of Fatty-Acid Synthase
2001
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
2000
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells
2004
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
DNA rendering of polyhedral meshes at the nanoscale
2015 Nature
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites
2004
Substrate-specific structural rearrangements of human Dicer
2013 StandoutNobel
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression
2019
Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
2004
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
2000
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformation
2004
A Bioorthogonal Reaction of N‐Oxide and Boron Reagents
2015 StandoutNobel
Pharmacological and small interference RNA‐mediated inhibition of breast cancer‐associated fatty acid synthase (oncogenic antigen‐519) synergistically enhances Taxol (paclitaxel)‐induced cytotoxicity
2005
Obesity and the Regulation of Energy Balance
2001 Standout
Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
2015 StandoutNobel
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
2006
The X‐ray crystal structure of β‐ketoacyl [acyl carrier protein] synthase I
1999
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Building machines with DNA molecules
2019
DNA nanotechnology from the test tube to the cell
2015
Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes
2001
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery
2020 StandoutNobel
The type I fatty acid and polyketide synthases: a tale of two megasynthases
2007
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
The microbial nitrogen-cycling network
2018 Standout
The Biosynthetic Logic of Polyketide Diversity
2009 Standout
Biosynthesis and function of polyacetylenes and allied natural products
2008
3d Transition Metals for C–H Activation
2018 Standout
DNA Origami: Scaffolds for Creating Higher Order Structures
2017
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
2001
DNA nanotechnology
2017
Total Synthesis of Borrelidin
2007 StandoutNobel
Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus
2014 StandoutNobel
The geometry of periodic knots, polycatenanes and weaving from a chemical perspective: a library for reticular chemistry
2018 StandoutNobel
How Biology Handles Nitrite
2014
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
Molecular Recognition in the Selective Oxygenation of Saturated C-H Bonds by a Dimanganese Catalyst
2006 Science
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
The complete genomic sequence of Nocardia farcinica IFM 10152
2004 Standout
Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes
2010
THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS
2005
Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors
2000 Science
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
Structural DNA Nanotechnology: State of the Art and Future Perspective
2014
A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool
2016 StandoutNobel
Dissecting the Chain Length Specificity in Bacterial Aromatic Polyketide Synthases using Chimeric Genes
2000
Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate
2015
Engineering Biomolecular Self‐Assembly at Solid–Liquid Interfaces
2020 StandoutNobel
Use of Plant Growth-Promoting Bacteria for Biocontrol of Plant Diseases: Principles, Mechanisms of Action, and Future Prospects
2005 Standout
DNA origami protection and molecular interfacing through engineered sequence-defined peptoids
2020 StandoutNobel
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense
2020
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
2004
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation
2013 Standout
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
DEAD-box helicases: the Yin and Yang roles in viral infections
2018
Mechanistic Analysis of a Type II Polyketide Synthase. Role of Conserved Residues in the β-Ketoacyl Synthase−Chain Length Factor Heterodimer
2000
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.
2000
Polyketide Chain Length Control by Chain Length Factor
2003
Works of M. Moche being referenced
Effect of nitrate supply and mycorrhizal inoculation on characteristics of tobacco root plasma membrane vesicles
2009
Azide and Acetate Complexes Plus Two Iron-depleted Crystal Structures of the Di-iron Enzyme Δ9 Stearoyl-Acyl Carrier Protein Desaturase
2003
Comparative Structural Analysis of Human DEAD-Box RNA Helicases
2010
Structure of the Complex between the Antibiotic Cerulenin and Its Target, β-Ketoacyl-Acyl Carrier Protein Synthase
1999
Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides
2013
The crystal structure of β-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 Å resolution and its relationship to other condensing enzymes11Edited by R. Huber
2001
A single mutation in the castor Δ 9 -18:0-desaturase changes reaction partitioning from desaturation to oxidase chemistry
2006
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
2016