Citation Impact
Citing Papers
Signal transduction and regulation in smooth muscle
1994 StandoutNature
Acyl-CoA-binding Protein Is a Potent m-Calpain Activator
2000
Cell‐penetrating inhibitors of calpain block both membrane fusion and filamin cleavage in chick embryonic myoblasts
1993
The Bovine Calpastatin Gene Promoter and a New N-terminal Region of the Protein Are Targets for cAMP-dependent Protein Kinase Activity
1998
Autophagy and other vacuolar protein degradation mechanisms
1992
Properties of calpastatin forms in rat brain
1998
Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation
1999
Myocardial calpain 2 is inhibited by monoclonal antibodies specific for the small noncatalytic subunit
1988
Pathophysiological role of calpain in experimental demyelination
1999
Purification of μ-Calpain by a Novel Affinity Chromatography Approach. NEW INSIGHTS INTO THE MECHANISM OF THE INTERACTION OF THE PROTEASE WITH TARGETS
1995
Dissociation of m-Calpain Subunits Occurs after Autolysis of the N-Terminus of the Catalytic Subunit, and Is Not Required for Activation
2001
Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycle
1989 StandoutNatureNobel
Molecular cloning of the cDNA for the large subunit of the high-calcium-requiring form of human calcium-activated neutral protease
1988
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
1988 StandoutNature
Activity-dependent scaling of quantal amplitude in neocortical neurons
1998 StandoutNature
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease
1997
New era of calpain research
1994
A Spatial-Temporal Model of Cell Activation
1988 Science
Ca2+-Dependent Proteolytic Modification of the Camp-Dependent Protein Kinase in Drosophila Wild-Type and Dunce Memory Mutants
1989
Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission
1991
Characterization of Two Recombinant Drosophila Calpains
1999
Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin?
1992
Rat brain contains multiple mRNAs for calpastatin1
1998
Characterization of a functional domain of human calpastatin
1990
Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts
1988
Neutrophil priming mechanisms of sulfolipid-I and n-formyl-methionyl-leucyl-phenylalanine
1994
A novel aspect of calpain activation
1998
Procalpain I in cytoplasm is translocated onto plasma and granule membranes during platelet stimulation with thrombin and then activated on the membranes
1992
Free calcium and calpain I activity
1991
Fatty acylated proteins as components of intracellular signaling pathways
1990
Subcellular Localization and in VivoSubunit Interactions of Ubiquitous μ-Calpain
2003
Sequence comparison among muscle-specific calpain, p94, and calpain subunits
1992
Investigation of the interaction of m-calpain with phospholipids: calpain-phospholipid interactions
1996
An endogenous inhibitor of calcium‐activated neutral protease in UMX 7.1 hamster dystrophy
1991
Phosphorylation of rat brain calpastatins by protein kinase C
1999
Identification of a third ubiquitous calpain species — chicken muscle expresses four distinct calpains
1995
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
'Oxidation Inhibits Substrate Proteolysis by Calpain I but Not Autolysis
1997
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Regulation of activity of calcium activated neutral protease
1988
The calpain-calpastatin system in obsessive-compulsive disorder
1997
A calpain-like activity insensitive to calpastatin in Drosophila melanogaster
2002
Calcium-dependent Signaling Pathways in T Cells
1997
Structural Basis for Possible Calcium-Induced Activation Mechanisms of Calpains
2001
A sarcolemma-associated inhibitor is capable of modulating calcium-dependent proteinase activity
1987
Calcium‐activated neutral proteinase (CANP; calpain) activity in Schwann cells: Immunofluorescence localization and compartmentation of μ‐ and mCANP
1991
A monoclonal antibody recognising the site of limited proteolysis of protein kinase C
1988
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase
1989 StandoutNobel
Binding sites for calcium-activated neutral protease on erythrocyte membranes are not membrane phospholipids
1990
Calpain and calpastatin regulate neutrophil apoptosis
1999
Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules
1988
Purification and characterization of a calpain activator from human platelets
1992
Autolysis of µ- and m-Calpain from Bovine Skeletal Muscle
2001
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Inhibition of Calpain Blocks Platelet Secretion, Aggregation, and Spreading
1999
Muscle-Specific Calpain, p94, Interacts with the Extreme C-Terminal Region of Connectin, a Unique Region Flanked by Two Immunoglobulin C2 Motifs
1997
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Calpains: Intact and active?
1997
cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase
1994 StandoutNobel
Persistent protein kinase activity underlying long-term potentiation
1988 Nature
Phosphorylation Modulates Calpain‐Mediated Proteolysis and Calmodulin Binding of the 200‐kDa and 160‐kDa Neurofilament Proteins
1993
Calpains and muscular dystrophies
2000
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons
1989 StandoutNatureNobel
The Structure of Calcium-Free Human m-Calpain Implications for Calcium Activation and Function
2001
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
2002 StandoutNature
Generation, Control, and Processing of Cellular Calcium Signals
2001
Domain III of Calpain Is a Ca2+-Regulated Phospholipid-Binding Domain
2001
Structure of the Calmodulin αII-Spectrin Complex Provides Insight into the Regulation of Cell Plasticity
2006 StandoutNobel
PEST Sequences Do Not Influence Substrate Susceptibility to Calpain Proteolysis
1995
Purification of Active Calpain by Affinity Chromatography on an Immobilized Peptide Inhibitor
1996
Points of control in inflammation
2002 StandoutNature
Cutting to the chase: calpain proteases in cell motility
2002
Partial Purification and Characterization of a Ca2+-Dependent Proteinase fromArabidopsisRoots
1997
A BODIPY Fluorescent Microplate Assay for Measuring Activity of Calpains and Other Proteases
2000
Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling
2001
Properties and Intracellular Localization of Calpain Activator Protein
2000
Domain II of m‐calpain is a Ca2+‐dependent cysteine protease
2001
Activation of calpain I and calpain II: A comparative study using terbium as a fluorescent probe for calcium-binding sites
1988
β1 Integrin-Mediated T Cell Adhesion and Cell Spreading Are Regulated by Calpain
2000
Modulation of rat brain calpastatin efficiency by post‐translational modifications
1997
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
A variety of calpain/calpastatin systems in mammalian erythrocytes
1993
m‐Calpain subunits remain associated in the presence of calcium
1998
Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis
1986 StandoutScience
Ca(2+)-activated neutral protease is active in the erythrocyte membrane in its nonautolyzed 80-kDa form.
1994
Site-directed activation of calpain is promoted by a membrane-associated natural activator protein
1993
Association of calpain (Ca2+-dependent thiol protease) with its endogenous inhibitor calpastatin in myoblasts
1999
Protein Oxidation and Aging
1992 StandoutScience
Isolated bovine myocardial sarcolemma and sarcoplasmic reticulum vesicles contain tightly bound calcium-dependent protease inhibitor
1987
CalpA, a Drosophila Calpain Homolog Specifically Expressed in a Small Set of Nerve, Midgut, and Blood Cells
1995
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system
1996
Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.
1982 StandoutNobel
Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.
1986
Role of arginine-tRNA in protein degradation by the ubiquitin pathway
1987 StandoutNatureNobel
The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family.
1996
Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein.
1987
Down-regulation of protein kinase C is due to an increased rate of degradation
1987
Purification and characterization of a protein inhibitor of calcium-dependent proteases from rat liver
1984
Properties of erythrocyte membrane binding and autolytic activation of calcium-activated neutral protease
1989
In situ Phosphorylation of Platelet Actin-binding Protein by cAMP-dependent Protein Kinase Stabilizes It against Proteolysis by Calpain
1989
Both protein kinase C and calcium mediate activation of the Na+/H+ antiporter in Chinese hamster embryo fibroblasts
1987
Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases.
1985
Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
1989 StandoutScienceNobel
Spectrin is associated with membrane-bound actin filaments in platelets and is hydrolyzed by the Ca2+-dependent protease during platelet activation
1987
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Autolysis parallels activation of μ-calpain
1996
Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIa.
1993
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Allomyces Ca2+-activated neutral protease: Interaction with phospholipids and plasma membranes
1989
Long-Term Potentiation--A Decade of Progress?
1999 StandoutScience
Protein synthesis during acquisition of long-term facilitation is needed for the persistent loss of regulatory subunits of the Aplysia cAMP-dependent protein kinase.
1990 StandoutNobel
Tracking the flow of learned information from membrane receptors to genome
1986 StandoutNobel
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
1991 StandoutNobel
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.
1987 StandoutNobel
Reversible interaction between Ca2+‐activated neutral protease (CANP) and its endogenous inhibitor
1985
Synaptic Activity and the Construction of Cortical Circuits
1996 StandoutScience
Calpain Regulates Actin Remodeling during Cell Spreading
1998
Activation and differentiation requirements of primary T cells in vitro.
1993 StandoutNobel
The Calpain System
2003 Standout
Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease
2000
Purification of an 11 S regulator of the multicatalytic protease.
1992
Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and μ-types
1989
The Ca2+-activated protease (calpain) modulates Ca2+/calmodulin dependent activity of smooth muscle myosin light chain kinase
1987
Intracellular proteolytic systems may function as secondary antioxidant defenses: An hypothesis
1986
Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.
1982 StandoutNobel
A sulfated metabolite produced bystf3negatively regulates the virulence ofMycobacteriumtuberculosis
2006 StandoutNobel
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.
1993
Integrin Signaling
1999 StandoutScience
Structure and physiological function of calpains
1997
Calmodulin Regulates Fodrin Susceptibility to Cleavage by Calciumdependent Protease I
1989
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
2003 StandoutNobel
Affinity labelling of the Ca2+-activated neutral proteinase (calpain) in intact human platelets
1993
In vitro and in vivo phosphorylation of calpain-like protease of Allomyces arbuscula
1991
Red blood cells contain a pathway for the degradation of oxidant-damaged hemoglobin that does not require ATP or ubiquitin.
1986
Proteinase involvement in the solubilization of 3-hydroxy-3-methylglutaryl coenzyme a reductase
1981
Proteolysis of the calcium-dependent protease inhibitor by myocardial calcium-dependent protease
1986
Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.
1988
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
Calcium-activated neutral protease inhibitor from rabbit erythrocytes lacks the N-terminal region of the liver inhibitor but retains three inhibitory units
1987
Differential distribution of protein kinase C isozymes in the various regions of brain.
1987
Albumin inhibits neutrophil spreading and hydrogen peroxide release by blocking the shedding of CD43 (sialophorin, leukosialin)
1993
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
1989 StandoutNobel
Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells
1991
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.
1990 StandoutNobel
Protein damage and degradation by oxygen radicals. I. general aspects.
1987 Standout
Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
1982 StandoutNobel
Monocyte responses to sulfatide from Mycobacterium tuberculosis: inhibition of priming for enhanced release of superoxide, associated with increased secretion of interleukin-1 and tumor necrosis factor alpha, and altered protein phosphorylation
1991
Molecular Mechanisms for Memory: Second-Messenger Induced Modifications of Protein Kinases in Nerve Cells
1987
Roles of individual EF-hands in the activation of m-calpain by calcium
2000
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
The role of autolysis in activity of the Ca2+-dependent proteinases (μ-calpain and m-calpain)
1989
Procalpain is activated on the plasma membrane and the calpain acts on the membrane
1987
Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function
1987
Calcium · calmodulin-dependent protein kinase II and calcium · phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide
1987
Specific degradation of troponin T and I by μ-calpain and its modulation by substrate phosphorylation
1995
Identification of Major Autolytic Cleavage Sites in the Regulatory Subunit of Vascular Calpain II
1989
Rapid microassay for protein kinase C translocation in Swiss 3T3 cells
1986 StandoutNobel
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
2000 Nobel
Effect of Ca2+ on binding of the calpains to calpastatin
1989
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Lipid modifications of G proteins: alpha subunits are palmitoylated.
1993 StandoutNobel
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Positive regulation of mu-calpain action by polyphosphoinositides.
1992
A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain.
1993
Purification of native p94, a muscle-specific calpain, and characterization of its autolysis
1998
Effect of monoclonal antibodies specific for the 28-kDa subunit on catalytic properties of the calpains.
1993
Molecular Diversity of Glutamate Receptors and Implications for Brain Function
1992 StandoutScience
Protein kinase C of smooth muscle.
1992
Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
1992 StandoutScienceNobel
Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene
1989
Works of M. Michetti being referenced
Effects of a monoclonal anti-calpain antibody on responses of stimulated human neutrophils. Evidence for a role for proteolytically modified protein kinase C.
1988
Molecular and Functional Properties of a Calpain Activator Protein Specific for μ-Isoforms
1998
Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase.
1986
The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.
1986
Modulation of inhibitory efficiency of rat skeletal muscle calpastatin by phosphorylation
1992
The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte
1994
Autolysis of human erythrocyte calpain produces two active enzyme forms with different cell localization
1996
Mechanism of action of the calpain activator protein in rat skeletal muscle
1991
Reversible Inactivation of Calpain Isoforms by Nitric Oxide
1995
Modulation of Calpastatin Specificity in Rat Tissues by Reversible Phosphorylation and Dephosphorylation
1994
Identification of two calpastatin forms in rat skeletal muscle and their susceptibility to digestion by homologous calpains
1991
Isovalerylcarnitine is a specific activator of the high calcium requiring calpain forms
1990
Mechanism of Action of a New Component of the Ca2+-Dependent Proteolytic System in Rat Brain: The Calpain Activator
1998
Activation of neutrophil calpain following its translocation to the plasma membrane induced by phorbol ester or fMet-Leu-Phe
1989
Modulation of the Calpain Autoproteolysis by Calpastatin and Phospholipids
1996
Identification of an endogenous activator of calpain in rat skeletal muscle
1990
Activation by hemoglobin of the Ca2+-requiring neutral proteinase of human erythrocytes: Structural requirements
1984
Characterization of the defective calpain-endogenous calpain inhibitor system in erythrocytes from Milan hypertensive rats
1986
Characterization of three rabbit liver lysosomal proteinases with fructose 1,6-bisphosphatase converting enzyme activity
1981
Regulation of the Ca2+-dependent neutral proteinases from rabbit liver by an endogenous inhibitor
1984
Following association to the membrane, human erythrocyte procalpain is converted and released as fully active calpain
1985
Phosphorylation by protein kinase C of a 20-kDa cytoskeletal polypeptide enhances its susceptibility to digestion by calpain.
1987
Identification of the proteolytically activated form of protein kinase C in stimulated human neutrophils.
1990
Reversible activation of human neutrophil calpain promoted by interaction with plasma membranes.
1985
Two cytosolic, Ca2+-dependent, neutral proteinases from rabbit liver: Purification and properties of the proenzymes
1984
Ca2+-dependent neutral proteinase from human erythrocytes: activation by Ca2+ ions and substrate and regulation by the endogenous inhibitor.
1984
Cytosolic Ca2+-dependent neutral proteinases from rabbit liver: activation of the proenzymes by Ca2+ and substrate.
1984
Binding to erythrocyte membrane is the physiological mechanism for activation of Ca2+-dependent neutral proteinase
1985
Differential mechanisms of translocation of protein kinase C to plasma membranes in activated human neutrophils
1986
Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.
1985
Evidence for an interaction between fructose 1,6-bisphosphatase and fructose 1,6-bisphosphate aldolase
1979
Calcium-binding properties of human erythrocyte calpain
1997
Identification of Proteolytic Activities in the Cytosolic Compartment of Mature Human Erythrocytes
1980
Cytosolic calcium dependent neutral proteinase of human erythrocytes: The role of calcium ions on the molecular and catalytic properties of the enzyme
1982
Cytosolic calcium dependent proteinase of human erythrocytes: Formation of an enzyme-natural inhibitor complex induced by Ca2+ ions
1982
Isovalerylcarnitine is a specific activator of calpain of human neutrophils
1987
Proteolysis of human reticulocyte membrane proteins: Evidence for a physiological role of the acid endopeptidases
1982
Decreased level of calpain inhibitor activity in red blood cells from Milan hypertensive rats
1986
Isozymes of protein kinase C in human neutrophils and their modification by two endogenous proteinases.
1990
Role of phospholipids in the activation of the Ca2+-dependent neutral proteinase of human erythrocytes
1985
An endogenous activator of the Ca2+-dependent proteinase of human neutrophils that increases its affinity for Ca2+.
1988
Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate.
1987
Characterization of the single peptide generated from the amino-terminus end of α- and β-hemoglobin chains by the Ca2+-dependent neutral proteinase
1984