Citation Impact
Citing Papers
Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer.
1990
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein
2000 StandoutNobel
Morphological classification of renal cancer
1995
Effects of an Rb mutation in the mouse
1992 StandoutNature
Clinical features and molecular genetics of Von Hippel-Lindau disease
1995
Tissue‐specific expression of a constitutional 3;6 translocation: Development of multiple bilateral renal‐cell carcinomas
1989
Surgical management of brainstem hemangioblastomas in patients with von Hippel—Lindau disease
2003
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours
1994
Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect
1995
Multiple Neuroendocrine Tumors of the Pancreas in von Hippel-Lindau Disease Patients
1998
Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli
1988 Nature
The chromosomal analysis of human solid tumors a triple challenge
1989
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
Mapping of the von Hippel-Lindau disease locus to a small region of chromosome 3p by genetic linkage analysis
1991
Histopathology and Molecular Genetics of Multiple Cysts and Microcystic (Serous) Adenomas of the Pancreas in von Hippel-Lindau Patients
2000
Bootstrapping in human genetic linkage
1994
Major role for a 3p21 region and lack of involvement of the t(3;8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis
1996
Renal-Cell Carcinoma
1996 Standout
A genetic model for colorectal tumorigenesis
1990 Standout
Molecular Analysis of the Short Arm of Chromosome 3 in Small-Cell and Non-Small-Cell Carcinoma of the Lung
1987
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
APC mutations occur early during colorectal tumorigenesis
1992 StandoutNature
Cytogenetics of papillary renal cell tumors
1991
von Hippel-Lindau Disease
1997 StandoutNobel
CpG-Island Methylation in Aging and Cancer
2000
Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein
1995 Science
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
1990 StandoutNature
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
Endolymphatic sac tumors: Histopathologic confirmation, clinical characterization, and implication in von hippel‐lindau disease
1995
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome
1990 StandoutNature
Development of multiple endocrine neoplasia type 2A does not involve substantial deletions of chromosome 10
1989
Differentiation Between Papillary and Nonpapillary Renal Cell Carcinomas by DNA Analysis
1989
Von Hippel-Lindau disease: identification of deletion mutations by pulsed-field gel electrophoresis
1993
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
von Hippel-Lindau disease
2003 Standout
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
Mutations in the p53 gene occur in diverse human tumour types
1989 StandoutNature
The p53 tumour suppressor gene
1991 StandoutNature
Expression of tumour-suppressor gene Rb, apoptosis-suppressing protein Bcl-2 and c-Myc have no independent prognostic value in renal adenocarcinoma
1995
Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa
1989
A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types
1994 StandoutScience
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Genetic alterations in sporadic renal-cell carcinoma: molecular analyses of tumor suppressor gene harboring chromosomal regions 3p, 5q, and 17p
1994
Mechanisms of angiogenesis
1997 StandoutNature
VHL, the story of a tumour suppressor gene
2014
von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease
1997
Pancreatic lesions in the von Hippel-Lindau syndrome
1991
Restriction fragment length polymorphism studies show consistent loss of chromosome 3p alleles in small cell lung cancer patients' tumors.
1988
Genetic Alterations during Colorectal-Tumor Development
1988 Standout
Surgical management of spinal cord hemangioblastomas in patients with von Hippel—Lindau disease
2003
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma
1996
Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus
1991
Angiogenesis as a therapeutic target
2005 StandoutNature
Novel mitochondrial DNA deletion found in a renal cell carcinoma
1996
Hereditary Papillary Renal Cell Carcinoma
1994
VHL Gene Deletion and Enhanced VEGF Gene Expression Detected in the Stromal Cells of Retinal Angioma
1999
Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.
1989
Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors
1992 StandoutScience
A genetic register for von Hippel-Lindau disease.
1996
Characterization of the Renal Pathology of a Familial Form of Renal Cell Carcinoma Associated With Von Hippel-Lindau Disease: Clinical and Molecular Genetic Implications
1995
p53 Mutations in Human Cancers
1991 StandoutScience
Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas.
1992
Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer.
1995
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
1994 StandoutScience
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.
1996
Infrequent Involvement of P53 Mutations and Loss of Heterozygosity of 17p in the Tumorigenesis of Renal Cell Carcinoma
1993
Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia
1997 Standout
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Localization of tumor suppressor loci on chromosome 9 in primary human renal cell carcinomas.
1995
Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma.
1990
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Cancer Cell Cycles
1996 StandoutScience
Loss of allelic heterozygosity at a second locus on chromosome 11 in sporadic Wilms' tumor cells.
1989
Frequency and structure of p53 rearrangements in human osteosarcoma.
1990
Allelotype of renal cell carcinoma.
1991
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
1993 StandoutNobel
Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients.
1996
Molecular mechanisms of oncogenesis.
1989
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
1990 StandoutScience
Concerted Nonsyntenic Allelic Loss in Human Colorectal Carcinoma
1988 Science
MUTATION OF THE VON HIPPEL-LINDAU TUMOUR SUPPRESSOR GENE IN CAPILLARY HAEMANGIOBLASTOMAS OF THE CENTRAL NERVOUS SYSTEM
1996
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
1994
Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.
1994
Tumor Suppressor Gene Allelic Loss in Human Renal Cancers
1993
The von Hippel-Lindau Tumor Suppressor Gene
2020
Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.
1990
Histopathological, cytogenetic, and molecular characterization of renal cortical tumors.
1991
Mitochondrial Diseases in Man and Mouse
1999 StandoutScience
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells
1988 Science
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma
1988 Science
p53: A Frequent Target for Genetic Abnormalities in Lung Cancer
1989 StandoutScience
Viruses in Human Cancers
1991 StandoutScienceNobel
Genetic Dissection of Complex Traits
1994 StandoutScience
The Role of DNA Methylation in Mammalian Epigenetics
2001 StandoutScience
Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.
1995
Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients
1990 StandoutScience
Clonal Analysis of Human Colorectal Tumors
1987 Science
Genetic flanking markers refine diagnostic criteria and provide insights into the genetics of Von Hippel Lindau disease.
1991
Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells.
1992 StandoutNobel
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Prevalence of Microscopic lesions in Grossly Normal Renal Parenchyma from Patients with von Hippel-Lindau Disease, Sporadic Renal Cell Carcinoma and No Renal Disease: Clinical Implications
1995
Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.
1987
Chromosome Aberrations and Cancer
1991 Science
Von Hippel-Lindau Syndrome
1999
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Effects of DNA methylation on topoisomerase I and II cleavage activities.
1994 StandoutNobel
Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas.
1994
Central nervous system lesions in von Hippel-Lindau syndrome.
1992
Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines.
1988
Detailed genetic mapping of the von Hippel-Lindau disease tumour suppressor gene.
1993
A microdissection technique for archival DNA analysis of specific cell populations in lesions < 1 mm in size.
1995
Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
1989 StandoutScience
Molecular analysis of genetic changes in the origin and development of renal cell carcinoma.
1991
Allelotype of human ovarian cancer.
1991
Analysis of genetic alterations in renal cell carcinoma using the polymerase chain reaction
1994
Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
1990 StandoutScience
Works of M. Linehan being referenced
Improved Detection of Allele Loss in Renal Cell Carcinomas After Removal of Leukocytes by Immunologic Selection
1989
Genetic Changes in Human Adrenocortical Carcinomas
1989
Specific Genetic Change in Tumors Associated With von Hippel-Lindau Disease
1989
Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
1987 Nature
Presymptomatic diagnosis of von Hippel-Lindau disease with flanking DNA markers.
1992 Nobel
Loss of Alleles of Loci on the Short Arm of Chromosome 3 in Renal Cell Carcinoma
1988
Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.
1993