Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors
1993
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
From molecular to modular cell biology
1999 StandoutNatureNobel
Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead
1996
Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice
1999
Pertussis toxin-catalyzed ADP-ribosylation of G0.alpha. with mutations at the carboxyl terminus
1992
G proteins: Critical control points for transmembrane signals
1994
Effect of Cellular Expression of Pleckstrin Homology Domains on Gi-coupled Receptor Signaling
1995 StandoutNobel
Go-protein α-Subunits Activate Mitogen-activated Protein Kinase via a Novel Protein Kinase C-dependent Mechanism
1996 StandoutNobel
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
1994 StandoutNatureNobel
Mutational Analysis of the Pleckstrin Homology Domain of the β-Adrenergic Receptor Kinase.
1995 StandoutNobel
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C
1992 Nature
Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation
1995 StandoutNobel
Stimulation of phospholipase C by guanine‐nucleotide‐binding protein βγ subunits
1992
Transgenic Mice with Cardiac Overexpression of α1B-Adrenergic Receptors
1997 StandoutNobel
Structural determinants for activation of the α-subunit of a heterotrimeric G protein
1994 Nature
Phosducin, Potential Role in Modulation of Olfactory Signaling
1997 StandoutNobel
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Identification of effector-activating residues of Gsα
1992
Protease‐activated receptors in hemostasis, thrombosis and vascular biology
2005
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
The P2Y1 receptor, necessary but not sufficient to support full ADP‐induced platelet aggregation, is not the target of the drug clopidogrel
1998
The GTPase superfamily: conserved structure and molecular mechanism
1991 StandoutNature
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
1989 Nature
Thrombin signalling and protease-activated receptors
2000 StandoutNature
N-Linked Glycosylation of Protease-activated Receptor-1 Second Extracellular Loop
2010
Identification, purification and characterization of a novel phosphatidylinositol‐specific phospholipase C, a third member of the β subfamily
1992
Structure of the pleckstrin homology domain from β-spectrin
1994 Nature
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Synaptotagmin I functions as a calcium regulator of release probability
2001 StandoutNatureNobel
The structure of the G protein heterotrimer Giα1β1γ2
1995 Nobel
Robustness in simple biochemical networks
1997 Nature
A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast
1989 StandoutNatureNobel
dgq: A drosophila gene encoding a visual system-specific Gα molecule
1990
Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits
1995 Nobel
Signal sorting and amplification through G protein-coupled receptors
1989
The 2.2 Å crystal structure of transducin-α complexed with GTPγS
1993 Nature
Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell
1989
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
G protein multiplicity in eukaryotic signal transduction systems
1988
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
1994 Nature
Diversity among the beta subunits of heterotrimeric GTP-binding proteins: Characterization of a novel beta-subunit cDNA
1992
New roles for G-protein (βγ-dimers in transmembrane signalling
1993 Nature
[12] Expression of G-protein a subunits in Escherichia coli
1994 StandoutNobel
Identification of the platelet ADP receptor targeted by antithrombotic drugs
2001 StandoutNatureNobel
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
1994 StandoutNatureNobel
Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator
1992
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Differential G protein—mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro
1989
G z -Mediated Hormonal Inhibition of Cyclic AMP accumulation
1992 Science
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
1994 StandoutNobel
Phosducin is a ubiquitous G-protein regulator.
1996
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.
1990 StandoutNobel
G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.
1991
Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins
1993 Science
Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide.
1990
Production, processing and partial purification of functional G protein βγ subunits in baculovirus-infected insect cells
1992
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Evidence for Two Distinct G-protein-coupled ADP Receptors Mediating Platelet Activation
1999
Pathway of vesicular stomatitis virus entry leading to infection
1982
Isolation of the alpha subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized beta gamma subunits.
1989
A G Protein γ Subunit Shares Homology with ras Proteins
1989 Science
Sites of interaction in the complex between beta- and gamma-subunits of transducin.
1990
Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes.
1992
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Existence of Two γ Subunits of the G Proteins in Brain
1989
Purification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class.
1991
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
1987 StandoutNatureNobel
Rhodopsin and the retinal G-protein distinguish among G-protein beta gamma subunit forms
1991
Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets
1989
The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy
1993
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.
1990 StandoutNobel
G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.
1990
G Proteins and Regulation of Adenylyl Cyclase
1989 StandoutNobel
Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors
1992
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.
1994
Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes.
1992 StandoutNobel
Purification, molecular cloning, and sequencing of phospholipase C-beta 4.
1993
Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.
1988
Interaction between G-protein beta and gamma subunit types is selective.
1992
Endocytosis in yeast: Several of the yeast secretory mutants are defective in endocytosis
1985
Characterization of the cDNA and Genomic Sequence of a G Protein γ Subunit (γ5)
1992
Monensin blocks the transport of diphtheria toxin to the cell cytoplasm.
1982
Endocytosis and the recycling of plasma membrane.
1983 StandoutNobel
Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.
1994
Lipid modifications of G protein subunits.
1991 StandoutNobel
Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.
1989
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
1992
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma
1992 StandoutNobel
Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits
1992
Neuronal expression of a newly identified Drosophila melanogaster G protein alpha 0 subunit.
1989
Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.
1993
Specificity of G protein beta and gamma subunit interactions.
1992
Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit.
1990
G olf : an Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction
1989 Science
In vitro synthesis of G protein βγ dimers
1991
Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans.
1991
Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits.
1993 StandoutNobel
G PROTEIN βγ SUBUNITS
1997
G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.
1991
Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin.
1995
Activation of phospholipase C isozymes by G protein beta gamma subunits.
1993
Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.
1992
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins.
1993
Retinal rods and cones have distinct G protein beta and gamma subunits.
1992
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.
1994
Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G q
1991 Science
Two G Protein Oncogenes in Human Endocrine Tumors
1990 Science
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
Characterization of the channel properties of tetanus toxin in planar lipid bilayers
1988
Purification of unique alpha subunits of GTP-binding regulatory proteins (G proteins) by affinity chromatography with immobilized beta gamma subunits.
1990
Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors.
1991
Molecular Basis of Regulation of Ionic Channels by G Proteins
1989
A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol
1994
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
1992 StandoutScienceNobel
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.
1994 StandoutNobel
ADP Receptors and Clinical Bleeding Disorders
1999
Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis
1987
5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.
1991 StandoutNobel
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
1994 StandoutNobel
Rapid acidification of endocytic vesicles containing α2-macroglobulin
1982
Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.
1991
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
Endosomes
1983
Regulation of inositol phospholipid-specific phospholipase C isozymes.
1992
Beta gamma-subunit activation of G-protein-regulated phospholipase C.
1992
Why are there so many adrenoceptor subtypes?
1994
Diversity of G Proteins in Signal Transduction
1991 StandoutScience
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
1991 StandoutScienceNobel
Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.
1994 StandoutNobel
Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.
1991
Works of M I Simon being referenced
Defective platelet activation in Gαq-deficient mice
1997 Nature
SIGNAL TRANSDUCTION PATHWAYS INVOLVING PROTEIN PHOSPHORYLATION IN PROKARYOTES
1991
Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.
1992
Gz, a guanine nucleotide-binding protein with unique biochemical properties.
1990 StandoutNobel
A segment of the C-terminal half of the G-protein beta 1 subunit specifies its interaction with the gamma 1 subunit.
1995
G protein diversity is increased by associations with a variety of gamma subunits.
1990
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
1993 StandoutNobel
G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.
1991
The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement.
1980
Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.
1992
Diphtheria toxin forms transmembrane channels in planar lipid bilayers.
1981
Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.
1991
Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.
1988
Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.
1993
The 35- and 36-kDa beta subunits of GTP-binding regulatory proteins are products of separate genes.
1988
Diphtheria toxin has the properties of a lectin.
1978
The N terminus of phosducin is involved in binding of beta gamma subunits of G protein.
1995