Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
2008 StandoutScience
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
2010 StandoutScience
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
2021 StandoutNobel
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2006 StandoutScience
Limits of long-term selection against Neandertal introgression
2019 StandoutNobel
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
2009 StandoutScience
Missense tau mutations identified in FTDP-17 have a small effect on tau–microtubule interactions
2000
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
2012
Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau
2015
LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
2010
Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
2014
Extracellular Tau Levels Are Influenced by Variability in Tau That Is Associated with Tauopathies
2012
I PP2A 1 Affects Tau Phosphorylation via Association with the Catalytic Subunit of Protein Phosphatase 2A
2008
Tau Isoform Composition Influences Rate and Extent of Filament Formation
2012
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
2009
Therapeutic strategies for tau mediated neurodegeneration
2012
The FTDP‐17‐Linked Mutation R406W Abolishes the Interaction of Phosphorylated Tau with Microtubules
2000
Axonal Transport RatesIn VivoAre Unaffected by Tau Deletion or Overexpression in Mice
2008
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
1999
Therapeutic strategies for Alzheimer's disease
2002
Synapses and Alzheimer's Disease
2012 StandoutNobel
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy
2005
Phenotypic presentation of frontotemporal dementia with Parkinsonism‐chromosome 17 type P301S in a patient of Jewish‐Algerian origin
2003
Pericytes are required for blood–brain barrier integrity during embryogenesis
2010 StandoutNature
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice
2000
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity
2012
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
2002 StandoutNature
Cortical Synapse Loss in progressive Supranuclear palsy
2001
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
2007 Standout
A novel presenilin 1 mutation associated with Pick's disease but not β‐amyloid plaques
2004
Aβ Oligomers – a decade of discovery
2007 Standout
Alzheimer Disease-specific Conformation of Hyperphosphorylated Paired Helical Filament-Tau Is Polyubiquitinated through Lys-48, Lys-11, and Lys-6 Ubiquitin Conjugation
2006
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
2008 Standout
Tau haplotypes regulate transcription and are associated with Parkinson's disease
2004
Going new places using an old MAP: tau, microtubules and human neurodegenerative disease
2001
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
2011
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Evidence for archaic adaptive introgression in humans
2015
A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia
2008
Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
2014
A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice
2016
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
A Haplotype at STAT2 Introgressed from Neanderthals and Serves as a Candidate of Positive Selection in Papua New Guinea
2012
Drug discovery in dementia: the role of rodent models
2006
Phenotypic variation in hereditary frontotemporal dementia with tau mutations
1999
Amyloid β-Protein Fibrillogenesis
1999
The genomic landscape of Neanderthal ancestry in present-day humans
2014 StandoutNatureNobel
Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
2013
The Relationship between Lewy Body Disease, Parkinson's Disease, and Alzheimer's Disease
2003
Amyloidosis and Alzheimer’s disease
2002
TauGene Mutation K257T Causes a Tauopathy Similar to Pick's Disease
2000
The tau gene in progressive supranuclear palsy: exclusion of mutations in coding exons and exon 10 splice sites, and identification of a new intronic variant of the disease-associated H1 haplotype in Italian cases
1999
Tau phosphorylation and aggregation in Alzheimer's disease pathology
2006
The Potential for β-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy
2008
apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
2008
A Hundred Years of Alzheimer's Disease Research
2006
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
2015
Mechanisms of Protein Seeding in Neurodegenerative Diseases
2012
Accumulation of Filamentous Tau in the Cerebral Cortex of Human Tau R406W Transgenic Mice
2005
Ubiquitin Immunohistochemistry Suggests Classic Motor Neuron Disease, Motor Neuron Disease With Dementia, and Frontotemporal Dementia of the Motor Neuron Disease Type Represent a Clinicopathologic Spectrum
2005
Reduction of Soluble Aβ and Tau, but Not Soluble Aβ Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles
2006
TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
2007
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
A Helical RGD Motif Promoting Cell Adhesion: Crystal Structures of the Helicobacter pylori Type IV Secretion System Pilus Protein CagL
2013
Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action
2014
Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
2010
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)
2011
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
2007 Standout
The Genetic and Pathological Classification of Familial Frontotemporal Dementia
2001
Tau in physiology and pathology
2015 Standout
Efficacy of small‐molecule glycogen synthase kinase‐3 inhibitors in the postnatal rat model of tau hyperphosphorylation
2007
Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval
2002
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Decoding ALS: from genes to mechanism
2016 StandoutNature
Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
2010
Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
2007
Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability
2012
Transgenic models of Alzheimer’s disease: Learning from animals
2005
Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements
2007
Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)
2005
Caspase activation precedes and leads to tangles
2010 Nature
Tau phosphorylation: physiological and pathological consequences
2004
Abnormal microtubule packing in processes of SF9 cells expressing the FTDP‐17 V337M tau mutation
1999
Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits
2006
Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions
2007
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Identification of a novel family of presenilin homologues
2002
Probing the Biology of Alzheimer's Disease in Mice
2010
Neuropathology of Alzheimer's disease and other dementias
2001
Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant
2011
Regulation of Tau Pathology by the Microglial Fractalkine Receptor
2010
Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family
2003
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
FTDP-17 Mutations in tau Transgenic Mice Provoke Lysosomal Abnormalities and Tau Filaments in Forebrain
2001
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
2007
Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations
2004
Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: A novel action of R406W mutation
2000
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
2010
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
2005
Alzheimer's Disease
2010 Standout
Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction
2012
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
2006
Overexpression of Wild-Type Murine Tau Results in Progressive Tauopathy and Neurodegeneration
2009
Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure
2001
In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons
2008
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
2012
Abnormal Tau-Containing Filaments in Neurodegenerative Diseases
2000
Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms
2005
Fibrillogenesis of Tau: Insights from Tau Missense Mutations in FTDP‐17
1999
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
2000 Standout
Transgenic animal models of tauopathies
2004
A Decade of Tau Transgenic Animal Models and Beyond
2007
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
2012
Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors
2008
Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
2012
In VivoMicrodialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice
2011
Identification of a novel polymorphism in the promoter region of the tau gene highly associated to progressive supranuclear palsy in humans
1999
Tau pathology in Alzheimer disease and other tauopathies
2004
Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles
2014
Tau Filament Formation in Transgenic Mice Expressing P301L Tau
2001
MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies
2012
Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy
2000
A network dysfunction perspective on neurodegenerative diseases
2006 Nature
Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease
2006
Molecular genetics of Alzheimer’s disease
2000
Changing perspectives regarding late-life dementia
2009
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Familial Alzheimer disease–linked mutations specifically disrupt Ca2+ leak function of presenilin 1
2007
Histopathological changes underlying frontotemporal lobar degeneration with clinicopathological correlation
2005
Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene
2000
The molecular pathology of Alzheimer's disease
1991 Standout
A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer’s Disease
2008
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
2003
Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy
2008
Post-translational modifications of tau protein: Implications for Alzheimer's disease
2011
Reduced Binding of Protein Phosphatase 2A to Tau Protein with Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Mutations
2000
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability
2006
The Aging Brain
2008
Molecular motors implicated in the axonal transport of tau and α-synuclein
2005
Significant association between the tau gene A0/A0 genotype and Parkinson's disease
2000
Neurodegenerative Tauopathies
2001 Standout
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia
2009
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Structure, Microtubule Interactions, and Paired Helical Filament Aggregation by Tau Mutants of Frontotemporal Dementias
2000
A Century of Alzheimer's Disease
2006 StandoutScience
Practice parameter: Management of dementia (an evidence-based review) [RETIRED]
2001 Standout
Mutations causing neurodegenerative tauopathies
2004
Competition for Microtubule-binding with Dual Expression of Tau Missense and Splice Isoforms
2001
Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies
2008
GSK-3 is essential in the pathogenesis of Alzheimer's disease
2006
The Slow Axonal Transport of the Microtubule-Associated Protein Tau and the Transport Rates of Different Isoforms and Mutants in Cultured Neurons
2002
Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
1999
Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy
2000
Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms
2006
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
2003 StandoutScience
From genetics to pathology: tau and a–synuclein assemblies in neurodegenerative diseases
2001
Missense and splice site mutations in tau associated with FTDP-17: Multiple pathogenic mechanisms
2001
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Alzheimer’s Disease: The Challenge of the Second Century
2011
Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice
2016
Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity
2006
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Role of Tau Protein in Both Physiological and Pathological Conditions
2004
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
2012
Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model
2007
The β-Propensity of Tau Determines Aggregation and Synaptic Loss in Inducible Mouse Models of Tauopathy
2007
Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17
1999 Nobel
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
Distinct FTDP-17 Missense Mutations in Tau Produce Tau Aggregates and Other Pathological Phenotypes in Transfected CHO Cells
2000
Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration
2013
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Pathological tau: a loss of normal function or a gain in toxicity?
2005
Effects of frontotemporal dementia FTDP‐17 mutations on heparin‐induced assembly of tau filaments
1999
Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations
2013
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
2006 Standout
Glyco-seek: Ultrasensitive Detection of Protein-Specific Glycosylation by Proximity Ligation Polymerase Chain Reaction
2016 StandoutNobel
Works of M. Hutton being referenced
Canadian Association of Neuropathologists Abstracts of papers and cases presented at the 44th Annual Meeting
2004
A decade of modeling Alzheimer's disease in transgenic mice
2006
The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer’s transgenic mice
2003
A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system
2012
A New Pathogenic Mutation in the APP Gene (I716V) Increases the Relative Proportion of A 42(43)
1997
Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy
1999
Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes
2000
Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells
2001
The molecular genetics of the tauopathies
2000
Frontotemporal dementia with Pick‐type histology associated with Q336R mutation in the tau gene
2004
Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation
1999
Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene
2002
Frequency oftau mutations in three series of non-Alzheimer's degenerative dementia
1999
BEYOND AMYLOID: The Next Generation of Alzheimer's Disease Therapeutics
2007
Neurodegenerative diseases of Guam: Analysis of TAU
1999
Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens
2005
Familial Frontotemporal Dementia Associated with a Novel Presenilin-1 Mutation
2002
Clinicopathologic correlation in PGRN mutations
2007
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
2005 StandoutScience