Standout Papers
Citation Impact
Citing Papers
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Induction of CD4+ T Cell Alloantigen-Specific Hyporesponsiveness by IL-10 and TGF-β
1999
Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers
1992
Adenoviral Transfer of the Viral IL-10 Gene Periarticularly to Mouse Paws Suppresses Development of Collagen-Induced Arthritis in Both Injected and Uninjected Paws
1999
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways
1998
Hallmarks of Cancer: The Next Generation
2011 Standout
The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity.
2001
Modulation of Formyl Peptide Receptor Expression by IL-10 in Human Monocytes and Neutrophils
1999
Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus.
1995
Functional diversity of helper T lymphocytes
1996 StandoutNature
Interleukin-10 Stimulation of Phosphatidylinositol 3-Kinase and p70 S6 Kinase Is Required for the Proliferative but Not the Antiinflammatory Effects of the Cytokine
1996
Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus
2000
Design and Analysis of an Engineered Human Interleukin-10 Monomer
2000
Dysregulation of T Helper Cell Cytokines in Autoimmune Prone NZB x NZW Fl Mice
1995
Protective Effects of Early Interleukin 10 Antagonism on Injury-Induced Immune Dysfunction
1999
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
1994 Nature
IL-10 AS A THERAPEUTIC STRATEGY IN THE TREATMENT OF RHEUMATOID ARTHRITIS
1998
Interleukin-10 Inhibition of HLA-DR Expression in Human Herpes Stromal Keratitis
1994
Relationship of Interleukin-10 Plasma Levels to Severity of Injury and Clinical Outcome in Injured Patients
1997
Increased mRNA Expression of IL‐10 in Mononuclear Cells in Multiple Sclerosis and Optic Neuritis
1995
Terminal differentiation of spontaneous rheumatoid factor–secreting B cells from rheumatoid arthritis patients depends on endogenous interleukin‐1 0
1995
Interleukin‐4 and ‐10 exacerbate candidiasis in mice
1995
RETROVIRAL DELIVERY OF VIRAL INTERLEUKIN-10 INTO MYELOID DENDRITIC CELLS MARKEDLY INHIBITS THEIR ALLOSTIMULATORY ACTIVITY AND PROMOTES THE INDUCTION OF T-CELL HYPORESPONSIVENESS1,2
1998
Synergistic effect betweenIL-10 andbcl-2 genotypes in determining susceptibility to systemic lupus erythematosus
1998
Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
1994
A community effect in animal development
1988 StandoutNatureNobel
Interleukin‐10 controls interferon‐γ and tumor necrosis factor production during experimental endotoxemia
1994
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
In vivo production of interleukin‐10 by non–t cells in rheumatoid arthritis, sjöugren's syndrome, and systemic lupus erythematosus.
1994
Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes
1995
Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers*
1997
Molecular and Cellular Events of T Cell Development
1989
IL-10 Up-Regulates CCR5 Gene Expression in Human Monocytes
1999
Expression of IL-10 receptors on epithelial cells from the murine small and large intestine
2000
Interleukin‐10: Potential Benefits and Possible Risks in Clinical Infectious Diseases
1998
Staphylococcal enterotoxin B and tumor‐necrosis factor‐α‐induced relapses of experimental allergic encephalomyelitis: Protection by transforming growth factor‐β and interleukin‐10
1995
Suppressive Effects of Interleukin‐10 on Human Mononuclear Phagocyte Function againstCandida albicansandStaphylococcus aureus
1998
IL-10 selectively regulates murine Ig isotype switching
1996
Interleukin 10 production correlates with pathology in human Leishmania donovani infections.
1993
Effects of single intravenous doses of recombinant human interleukin-10 on subsets of circulating leukocytes in humans
1999
Origin of Murine B Cell Lineages
1993
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Interleukin 10 prevents necrosis in murine experimental acute pancreatitis
1995
Mapping of the human IL10 gene and further characterization of the 5' flanking sequence
1997
IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
1998
Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding
1999
High Levels Of Interleukin-10 During The Initial Phase Of Fulminant Meningococcal Septic Shock
1995
Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules
1997
Interleukin-10 inhibits neutrophil phagocytic and bactericidal activity
1996
Immune complexes inhibit antimicrobial responses through interleukin-10 production. Effects in severe combined immunodeficient mice during Listeria infection.
1995
Identification and functional characterization of a second chain of the interleukin-10 receptor complex
1997
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
1996
Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
1995
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
2000 Standout
Interleukin 10 Treatment of Psoriasis
1999
Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells
1994
Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock
1995
Effect in vitro of gamma interferon and interleukin-10 on generation of oxidizing species by human granulocytes
1996
Experimental Leishmania major infection in mice: role of IL‐10
1999
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
1993 Standout
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages
1992
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling
1997
SYSTEMIC ADMINISTRATION OF ANTI-INTERLEUKIN-10 ANTIBODY PROLONGS ORGAN ALLOGRAFT SURVIVAL IN NORMAL AND PRESENSITIZED RECIPIENTS1,2
1998
The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-like gene
1993
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
1998 Standout
Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.
1993
Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis.
1995
The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus
1999
Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: A pilot trial of interferon nonresponders
2000
Interleukin‐10 inhibition of the progression of established collagen‐induced arthritis
1996
Markers in the promoter region of interleukin-10 (IL-10) gene in myasthenia gravis: implications of diverse effects of IL-10 in the pathogenesis of the disease
1999
IL-10 immunosuppression in transplantation
1995
The role of interleukin-10 in systemic lupus erythematosus
2003
ATP-sensitive potassium channels mediate survival during infection in mammals and insects
2007 StandoutNobel
Interleukin 10 Inhibits the Release of CC Chemokines during Human Endotoxemia
2000
Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
1997
In vivo effects of locally secreted IL-10 on the murine antitumor immune response
1996
INTERLEUKIN-10 DOSE-DEPENDENT REGULATION OF CD4+ AND CD8+ T CELL-MEDIATED GRAFT-VERSUS-HOST DISEASE1
1998
Cytokine regulation of T-cell function: potential for therapeutic intervention
1993
Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β
1995
Interleukin-10 Enhances Tumor Necrosis Factor-α Activation of HIV-1 Transcription in Latently Infected T Cells
1998
Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation
1999
A TH1→TH2 switch is a critical step in the etiology of HIV infection
1993
Recent advances in cancer stem cells
2008
In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.
1993
CD22 is a negative regulator of B-cell receptor signalling
1997 Nobel
Interleukin-10 in Non-Hodgkin's Lymphoma
1997
SYSTEMIC ADMINISTRATION OF CELLULAR INTERLEUKIN-10 CAN EXACERBATE CARDIAC ALLOGRAFT REJECTION IN MICE1,2
1996
Interleukin-10 Is Associated with the Development of Sepsis in Trauma Patients
1996
Interleukin-10 and the Monocyte/Macrophage-Induced Inflammatory Response in Septic Shock
1995
Recombinant Human Interleukin‐10 Fails to Alter Proinflammatory Cytokine Production or Physiologic Changes Associated with the Jarisch‐Herxheimer Reaction
2000
Clinical, hematologic, and immunologic effects of interleukin-10 in humans
1996
Interleukin-10 (IL-10) Augments Allograft Arterial Disease
1999
Lymphocyte responses and cytokines
1994 Standout
Interleukin-10-deficient mice develop chronic enterocolitis
1993 Standout
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
1996
Contrasting effects of IL-4, IL-10 and corticosteroids on RANTES production by human monocytes
1996
A Pilot Study of Daily Subcutaneous Interleukin-10 in Patients with Chronic Hepatitis C Infection
1999
Interleukin‐10 prevents experimental allergic encephalomyelitis in rats
1994
Signaling thresholds and interclonal competition in preimmune B‐cell selection
1997
Enhancement of endotoxin‐induced interleukin‐10 production by SR 31747A, a sigma ligand
1995
Oxazolone Colitis, a Th2 Colitis Model Resembling Ulcerative Colitis, Is Mediated by IL-13-Producing NK-T Cells
2002
Interleukin‐10 does not affect phagocytosis of particulate antigen by bonemarrow‐derived dendritic cells but does impair antigen presentation
2000
Interleukin 10 Treatment Does Not Prolong Experimental Corneal Allograft Survival
1999
Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor
1996
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10
2007
Adenovirus-Mediated Gene Transfer of Viral Interleukin-10 Inhibits the Immune Response to Both Alloantigen and Adenoviral Antigen
1997
Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.
1995
Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
2003
Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells.
1996
Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate
1995
Pharmacokinetics and Leukocyte Responses of Recombinant Human Interleukin-10
1998
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
1998
The human interleukin-10 receptor gene maps to chromosome 11q23.3
1995
Taking dendritic cells into medicine
2007 StandoutNatureNobel
In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13.
1997
Dysregulation of interleukin‐10 production in relatives of patients with systemic lupus erythematosus
1997
IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses
1996 Nobel
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
1993 StandoutNatureNobel
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
T cell cytokine imbalance towards production of IFN‐γ and IL‐10 in NZB/W F1 lupus‐prone mice is associated with autoantibody levels and nephritis
2006
Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction.
1994
Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa
1999
Secondary structure and topology of human interleukin 4 in solution
1991
Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4
1998
Regulation of Tumor Growth and Metastasis by Interleukin-10: The Melanoma Experience
1999
T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection.
1994
A PILOT TRIAL OF RECOMBINANT HUMAN INTERLEUKIN-10 IN KIDNEY TRANSPLANT RECIPIENTS RECEIVING OKT3 INDUCTION THERAPY1,2
1997
Disposition of Recombinant Human Interleukin‐10 in Subjects with Various Degrees of Renal Function
1999
Pharmacoimmunodynamic interactions of interleukin-10 and prednisone in healthy volunteers
1999
Regulatory T cells in the control of immune pathology
2001
Interleukin 10 inhibits cytokine production of human AML cells
1996
Interieukin-10 Impairs Host Defense in Murine Pneumococcal Pneumonia
1996
Differential Regulation of the Stability of Cytokine mRNAs in Lipopolysaccharide-activated Blood Monocytes in Response to Interleukin-10
1996
Progression of Mycosis Fungoides Is Associated with Increasing Cutaneous Expression of Interleukin-10 mRNA
1996
Role of interleukin 10 in specific immunotherapy.
1998 Standout
Differential Regulation of Murine T Lymphocyte Subsets
1993
T Cells of Lupus and Molecular Targets for Immunotherapy
1997
Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis: IL-10-dependent CD4+CD45RO+ T cell-B cell antibody synthesis
1996
Listeria monocytogenes in laboratory mice: a model of short‐term infectious and pathogenic processes controllable by regulated protective immune responses
1997
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation
2000
Modulatory effect of interleukin‐10 on the production of platelet‐activating factor and superoxide anions by human leucocytes
1997
The Primary Immunodeficiencies
1995
The antipsoriatic activity of IL-10 is rather caused by effects on peripheral blood cells than by a direct effect on human keratinocytes
2000
In Vitro Restoration of T Cell Immune Function in Human Immunodeficiency Virus-Positive Persons: Effects of Interleukin (IL)-12 and Anti-IL-IO
1996
Regulatory T cells and inflammatory bowel disease
1999
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells
1995 Nature
Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.
1994
Antiinflammatory Cytokine Responses during Clinical Sepsis and Experimental Endotoxemia: Sequential Measurements of Plasma Soluble Interleukin (IL)-1 Receptor Type II, IL-10, and IL-13
1997
Monocyte deactivation-rationale for a new therapeutic strategy in sepsis
1996
AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER
1997
Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a tumor necrosis factor–dependent murine model of acute visceral ischemia
1997
Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β
1996
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
1995
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Tumour necrosis factor and other cytokines in murine lupus
1999
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.
1994
GRAIL
2003
The neutrophil: one of the cellular targets of interleukin-10
1998
Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA.
1994
High-dose cellular IL-10 exacerbates rejection and reverses effects of cyclosporine and tacrolimus in mouse cardiac transplantation
1997
Characterization of Recombinant Extracellular Domain of Human Interleukin-10 Receptor
1995
A review of the association between interleukin-10 and human B-cell malignancies
1998
IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach.
1998
Interleukin-10 and interleukin-6 in lupus erythematosus and rheumatoid arthritis, correlations with acute phase proteins
1997
Autoimmunity-Prone B-L (Cd5 B) Cells, Natural Antibodies and Self Recognition
1993
Detection of soluble interleukin-2 receptor and interleukin-10 in the serum of patients with aggressive non-Hodgkin's lymphoma.Identification of a subset at high risk of treatment failure
1994
Interleukin-13 Effectively Down-regulates the Monocyte Inflammatory Potential During Traumatic Stress
1995
Role of interleukin‐4 and interleukin‐10 in murine collagen‐induced arthritis. Protective effect of interleukin‐4 and interleukin‐10 treatment on cartilage destruction
1997
Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor
1996
Increased frequency of interleukin 4‐producing T cells as a result of polyclonal priming. Use of a single‐cell assay to detect interleukin 4‐producing cells
1991
Antifungal type 1 responses are upregulated in IL-10-deficient mice
1999
Inhaled Corticosteroids Increase Interleukin-10 but Reduce Macrophage Inflammatory Protein-1 α , Granulocyte-Macrophage Colony-stimulating Factor, and Interferon- γ Release from Alveolar Macrophages in Asthma
1998
Interleukin-10 Gene Transfer to the Airway Regulates Allergic Mucosal Sensitization in Mice
1999
Depletion of IL-10- and TGF-β-Producing Regulatory γδ T Cells by Administering a Daunomycin-Conjugated Specific Monoclonal Antibody in Early Tumor Lesions Augments the Activity of CTLs and NK Cells
1999
Crystal structure of recombinant human interleukin-4.
1992
Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression
1996
B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells.
1993
Protein-Specific Helper T-Lymphocyte Formation Initiated by Dendritic Cells
1985 StandoutScienceNobel
A receptor for interleukin 10 is related to interferon receptors.
1993
Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors.
1995
Interleukin-10 induces E-selectin on small and large blood vessel endothelial cells.
1996
Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis
1998
CH Isotype 'Switching' During Normal B-Lymphocyte Development
1984
T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing Both T Cell and APC Function
1999
Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells
1999
Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells
1998 StandoutNobel
Interleukin -10and Related Cytokines and Receptors
2004
An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.
1992
IL-10 augments CD23 expression on U937 cells and down-regulates IL-4-driven CD23 expression on cultured human blood monocytes: effects of IL-10 and other cytokines on cell phenotype and phagocytosis.
1995
Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta.
1995
IL-10 Converts Human Dendritic Cells into Macrophage-Like Cells with Increased Antibacterial Activity Against Virulent Mycobacterium tuberculosis
2000
The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor
1998
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Interleukin 5 induces S mu-S gamma 1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: a three component model for Ig class switching.
1993
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.
1995
IL-10 Gene Knockout Mice Show Enhanced Th1-Like Protective Immunity and Absent Granuloma Formation FollowingChlamydia trachomatisLung Infection
1999
Interleukin 4 (B-cell growth factor II/eosinophil differentiation factor) is a mitogen and differentiation factor for preactivated murine B lymphocytes.
1986
A Single Amino Acid Determines the Immunostimulatory Activity of Interleukin 10
2000
Factors Affecting B-Cell Growth and Differentiation
1985
Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway.
1994
Coupling of Peripheral Tolerance to Endogenous Interleukin 10 Promotes Effective Modulation of Myelin-Activated T Cells and Ameliorates Experimental Allergic Encephalomyelitis
2000
Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells
1999
Characterization of interleukin-10 receptors on human and mouse cells.
1993
Endogenous IL-10 protects mice from death during septic peritonitis
1995
Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo
1999
Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.
1989
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
The Cytokine Profile Expressed by Human Dendritic Cells Is Dependent on Cell Subtype and Mode of Activation
1998
Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.
1986
Treatment of Experimental Viral Myocarditis With Interleukin-10
1999
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.
1992
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.
1995
Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses.
1995
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.
1987
Interleukin-10 protects neonatal mice from lethal group B streptococcal infection
1996
Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4
1995
In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: differential modulation by cyclosporin A.
1993
Reversal of Proinflammatory Responses by Ligating the Macrophage Fcγ Receptor Type I
1998
A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages
2000
Epstein-Barr virus recombinants with specifically mutated BCRF1 genes
1993
Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.
1993
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.
1992
Adaptation of Lymphadenopathy Associated Virus (LAV) to Replication in EBV-Transformed B Lymphoblastoid Cell Lines
1984 StandoutScienceNobel
The Biochemistry, Biology, and Role of Interleukin 2 in the Induction of Cytotoxic T Cell and Antibody‐Forming B Cell Responses
1982
Production of interleukin-10 by human bronchogenic carcinoma.
1994
Serum levels of interleukin-10 in patients with diffuse large cell lymphoma: lack of correlation with prognosis [see comments]
1995
Identification of an IL-10-Producing HLA-DR-Negative Monocyte Subset in the Malignant Ascites of Patients with Ovarian Carcinoma That Inhibits Cytokine Protein Expression and Proliferation of Autologous T Cells
1999
Defects in the regulation of anti-DNA antibody production in aged lupus-prone (NZB x NZW)F1 mice: analysis of T-cell lymphokine synthesis.
1995
Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.
1996
Functional Regions of the Mouse Interleukin-10 Receptor Cytoplasmic Domain
1995
Phorbol myristate acetate inhibits anti-IgM-mediated signaling in resting B cells.
1986
Interleukin 4 induces membrane Thy-1 expression on normal murine B cells.
1988
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.
1994
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
1998
Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.
1993
Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity
1995
Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue
1986 StandoutNobel
Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.
1991
Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.
1994
Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation.
1995
Regulation of Ig Class Secretion by Soluble Products of Certain T‐Cell Lines
1984
Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts
1995
Exogenous cytokine modulation or neutralization of interleukin‐10 enhance survival in lipopolysaccharide‐hyporesponsive C3H/HeJ mice with Klebsiella infection
1999
IL-12 Acts Selectively on CD8α− Dendritic Cells to Enhance Presentation of a Tumor Peptide In Vivo
1999
Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees.
1994
Interleukin 10 reduces mortality from severe peritonitis in mice
1995
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
2004 StandoutNobel
Interleukin‐10‐induced CD8 cell proliferation
1999
Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.
1991
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.
1996
Treatment with anti-interleukin-10 monoclonal antibody enhances early resistance to but impairs complete clearance of Listeria monocytogenes infection in mice
1994
A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells
1999
Regulation by Interleukin-10 and Interleukin-4 of Cyclooxygenase-2 Expression in Human Neutrophils
1997
Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia.
1997
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
1993 StandoutScience
Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers
1996
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
1984 Nature
Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II
1986 StandoutNatureNobel
Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.
1987 StandoutNobel
Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.
1992
Anti-Programmed Cell Death 1 Antibody Reduces CD4+PD-1+ T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice
2010 StandoutNobel
Crystal structure of recombinant human interleukin-4.
1992
The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.
1996
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
2004
Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.
1994
Transcription of the interleukin 4 gene is regulated by multiple promoter elements.
1993
Altered Immune Responses in Interleukin 10 Transgenic Mice
1997
Induction of hapten-specific tolerance by interleukin 10 in vivo.
1994
B Cell Growth and Differentiation Factors
1984
Macrophage deactivation by interleukin 10.
1991
IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections.
1993
IFN-α Priming Results in a Gain of Proinflammatory Function by IL-10: Implications for Systemic Lupus Erythematosus Pathogenesis
2004
IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.
1996
Interleukin-10 Inhibits Activation of Coagulation and Fibrinolysis During Human Endotoxemia
1997
IT 9302, a synthetic interleukin-10 agonist, diminishes acute lung injury in rabbits with acute necrotizing pancreatitis
1998
Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.
1991 Standout
IL-10 Is a Major Mediator of Sepsis-Induced Impairment in Lung Antibacterial Host Defense
1999
Phenotypic and Functional Analysis of Activated B Cells of Autoimmune NZB × NZW F1 Mice
1998
Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.
1994
Human interleukin-10 can directly inhibit T-cell growth
1993
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Molecular dissection of the mouse interleukin-4 promoter.
1993
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.
1989 Standout
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Lipopolysaccharide-dependent induction of IL-10 receptor expression on murine fibroblasts.
1994
Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.
1984
Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.
1986
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter
1986 StandoutNatureNobel
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.
1994
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Constitutive IL-10 Production Accounts for the High NK Sensitivity, Low MHC Class I Expression, and Poor Transporter Associated with Antigen Processing (TAP)-1/2 Function in the Prototype NK Target YAC-1
1998
Factors Controlling the B-Cell Cycle
1986
Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.
1982
The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
2004
Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor
1993
Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock
1993
Seppuku and Autoimmunity
1992 StandoutScienceNobel
Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia
1994 StandoutNobel
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
1994
Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection
1986 StandoutNatureNobel
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
Regulation of Growth and Proliferation in B Cell Subpopulations
1982
A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice.
1997
Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.
1994
Sequences and Factors: A Guide to MHC Class-II Transcription
1992
Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.
1986
Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.
1999
Maintenance of in Vivo Tolerance by Persistence of Antigen
1992 StandoutScienceNobel
Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis.
1996
Lack of Evidence for the Dichotomy of T H 1 and T H 2 Predominance in HIV-Infected Individuals
1994 Science
Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.
1993
Interleukin-10 Upregulates Tumor Necrosis Factor Receptor Type-II (p75) Gene Expression in Endotoxin-Stimulated Human Monocytes
1997
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.
1990
Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10
1992
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
1993
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.
1983
IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice
1998
Immunoregulatory role of interleukin 10 in rheumatoid arthritis.
1994
Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis
1999
Interleukin-10 inhibits interleukin-8 production in human neutrophils
1994
Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells.
1998
Cutting Edge: Clustered AU-Rich Elements Are the Target of IL-10-Mediated mRNA Destabilization in Mouse Macrophages
1999
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis.
1984
Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells
1997
High levels of interleukin 10 in serum are associated with fatality in meningococcal disease
1995
Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta.
1999
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis.
1996
B-cell growth factor: distinction from T-cell growth factor and B-cell maturation factor.
1982
Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.
1986
Chlorpromazine specifically inhibits peripheral and brain TNF production, and up-regulates IL-10 production, in mice.
1994
Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2.
1994
Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).
1985
Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium.
1987 StandoutNobel
Listeria meningitis: identification of a cerebrospinal fluid inhibitor of macrophage listericidal function as interleukin 10.
1993
Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1
1985 Nature
Tumor Necrosis Factor Alpha-Mediated Toxic Shock inTrypanosoma cruzi-Infected Interleukin 10-Deficient Mice
2000
Effect of IL-10 on collagen-induced arthritis in mice
1996
Dendritic cells induce T lymphocytes to release B cell-stimulating factors by an interleukin 2-dependent mechanism.
1983
Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.
1984
In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen.
1993
Dual Role of Interleukin-10 in Murine Lyme Disease: Regulation of Arthritis Severity and Host Defense
1999
IL-12 acts selectively on CD8 alpha- dendritic cells to enhance presentation of a tumor peptide in vivo.
1999
Tolerant B Lymphocytes Acquire Resistance to Fas-mediated Apoptosis after Treatment with Interleukin 4 but Not after Treatment with Specific Antigen Unless a Surface Immunoglobulin Threshold Is Exceeded
1998
Interleukin 10 inhibits growth and granulocyte/macrophage colony-stimulating factor production in chronic myelomonocytic leukemia cells.
1996
Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.
1993
The biology of interleukin-6
1989 Standout
STF-IL-4: a novel IL-4-induced signal transducing factor.
1994
Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II.
1987 StandoutNobel
Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.
1982
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
2000
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
1991 Standout
Regulation by Interleukin-10 and Interleukin-4 of Cyclooxygenase-2 Expression in Human Neutrophils
1997
Molecular cloning of cDNA encoding human interleukin-2 receptor
1984 StandoutNatureNobel
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.
1994
Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation.
1994
Interleukin-4 and Interleukin-10 Are Involved in Host Resistance toStaphylococcus aureusInfection through Regulation of Gamma Interferon
2000
Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.
1992
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.
1992
Identification of functional domains on human interleukin 10
1997
Interleukin-10 inhibits motility in murine and human B lymphocytes.
1994
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.
1995
Dual Roles for Immunity in Gastrointestinal Cancers
2010
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.
1994
Inhibitory and Stimulatory Effects of IL-10 on Human CD8+ T Cells
1998
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Partial biochemical characterization of IgG1‐inducing factor
1985
Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis
1995
Release of interleukin-12 in experimental Escherichia coli septic shock in baboons: relation to plasma levels of interleukin-10 and interferon- gamma
1996
Origin and Characteristics of Ultraviolet-B Radiation-Induced Suppressor T Lymphocytes
1998
Works of M Howard being referenced
Induction of antigen-specific proliferation in affinity-purified small B lymphocytes: requirement for BSF-1 by type 2 but not type 1 thymus-independent antigens.
1986
Structure of the IL4 receptor and signal transduction mechanism of IL4
1993
Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin.
1993
Local cytokine production in a murine model of Escherichia coli pyelonephritis.
1992
Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding.
1990
Identification of an essential region for growth signal transduction in the cytoplasmic domain of the human interleukin-4 receptor
1992
Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.
1983
Up-regulation of interleukin 4 receptor expression on immature (Lyt-2-/L3T4-) thymocytes.
1988
Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression.
1996
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.
1994
Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2.
1983
Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells.
1988
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
1991 Standout
Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation.
1983
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.
1982
Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.
1990
B lymphocyte subpopulations separated by velocity sedimentation. I. Characterization of immune function in an in vitro splenic focus assay.
1978
Long-term culture of normal mouse B lymphocytes.
1981
IL-10 inhibits cytokine production by activated macrophages
1991 Standout
Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny.
1987
Protective effects of IL-4 and IL-10 against immune complex-induced lung injury.
1993
Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells
1996
Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-I.
1983
Soluble factors involved in B cell differentiation: identification of two distinct T cell-replacing factors (TRF).
1983
Interleukin 10 protects mice from lethal endotoxemia.
1993
Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice.
1994 StandoutNobel
IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production.
1997
Responses of B cells from autoimmune mice to IL-5.
1989
Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.
1992