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Citing Papers
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
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Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O -GlcNAc in diabetes-associated erectile dysfunction
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2008
Oxidative stress indices in IDDM subjects with and without long-term diabetic complications
2001
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2005
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2010
Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells
1998
Advanced glycosylation end products induce inducible nitric oxide synthase (iNOS) expression via a p38 MAPK-dependent pathway
2004
Inflammation and metabolic disorders
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Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats
1997
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
2000 StandoutNature
Long-term Treatment with Suberythropoietic Epo is Vaso- and Neuroprotective in Experimental Diabetic Retinopathy
2011
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation
2005
Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins.
1992
Dynamic Covalent Chemistry
2002 StandoutNobel
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
1999 StandoutNature
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2009
Insulin Enhances Macrophage Scavenger Receptor-mediated Endocytic Uptake of Advanced Glycation End Products
1998
Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats.
1993
Discovery and Confirmation of O-GlcNAcylated Proteins in Rat Liver Mitochondria by Combination of Mass Spectrometry and Immunological Methods
2013
Chemoselective ligation reactions with proteins, oligosaccharides and cells
1998
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.
1998
High Glucose Inhibits Insulin-stimulated Nitric Oxide Production without Reducing Endothelial Nitric-oxide Synthase Ser1177 Phosphorylation in Human Aortic Endothelial Cells
2003
Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose
1995
Advanced Glycation End Product-induced Apoptosis and Overexpression of Vascular Endothelial Growth Factor and Monocyte Chemoattractant Protein-1 in Human-cultured Mesangial Cells
2002
Intervention strategies to inhibit protein carbonylation by lipoxidation‐derived reactive carbonyls
2006
Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro
1993
Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1α
2007
O-GlcNAc cycling: Implications for neurodegenerative disorders
2009
Nitric oxide synthases: structure, function and inhibition
2001 Standout
Advanced glycation end products increase retinal vascular endothelial growth factor expression.
1998
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells
1998
Synergism through direct covalent bonding between agents: A strategy for rational design of chemotherapeutic combinations
1990
Glycation induces expansion of the molecular packing of collagen
1988
RAGE (receptor for advanced glycation end products): a central player in the inflammatory response
2004
Role of nitric oxide in diabetic nephropathy
2004
Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients.
1997
Metabolic Delivery of Ketone Groups to Sialic Acid Residues
1998 StandoutNobel
A New Perspective on Therapeutic Inhibition of Advanced Glycation in Diabetic Microvascular Complications: Common Downstream Endpoints Achieved Through Disparate Therapeutic Approaches?
2009
SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy
2007
Macrophage Responses to Hypoxia
2005
Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat
2002
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine
2009
The Role of Oxidative Stress in Diabetic Complications
2005
Insulin Resistance of Glycogen Synthase Mediated byO-Linked N-Acetylglucosamine
2003
O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress
2004
Free radicals and antioxidants in normal physiological functions and human disease
2006 Standout
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells
2003
Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility
1997
Fibulin-5/DANCE is essential for elastogenesis in vivo
2002 StandoutNatureNobel
Atherosclerosis — An Inflammatory Disease
1999 Standout
Inflammation in atherosclerosis
2002 StandoutNature
Origin and physiological roles of inflammation
2008 StandoutNature
Inhibitors of Advanced Glycation End Product Formation and Neurovascular Dysfunction in Experimental Diabetes
2005
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Multiple Metabolic Hits Converge on CD36 as Novel Mediator of Tubular Epithelial Apoptosis in Diabetic Nephropathy
2005
Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications
2005
O‐GlcNAc turns twenty: functional implications for post‐translational modification of nuclear and cytosolic proteins with a sugar
2003
O-GlcNAc modification of nucleocytoplasmic proteins and diabetes
2005
Clinical Score for Predicting Recurrence After Hepatic Resection for Metastatic Colorectal Cancer
1999 Standout
Retinopathy in animal models of diabetes
1995
Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.
1994
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
2007 Nature
Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease
2004
Diabetic Retinopathy
2003
Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195
1999
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
1988 Standout
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
2003
Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy
2010
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
2006
Matrix protein glycation impairs agonist‐induced intracellular Ca2+ signaling in endothelial cells
2002
Molecular mechanisms of ageing in connective tissues
2001
Liquid chromatography-based determination of urinary free and total N(epsilon)-(carboxymethyl)lysine excretion in normal and diabetic subjects
2003
Possible role of tumor necrosis factor and interleukin-1 in the development of diabetic nephropathy
1991
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
2003
Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats
2010
The formation of reactive intermediate(s) of glucose 6-phosphate and lysine capable of rapidly reacting with DNA
1987
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
2015 StandoutNobel
The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code"
2005
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
Modulatory effects of HMG‐CoA reductase inhibitors in diabetic microangiopathy
2004
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction
2006 Standout
Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia
2001
Retinal Expression of Vascular Endothelial Growth Factor Is Mediated by Angiotensin Type 1 and Type 2 Receptors
2004
Advanced Glycation End Products
2006 Standout
Exploiting Differences in Sialoside Expression for Selective Targeting of MRI Contrast Reagents
1999 StandoutNobel
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
Compromised Arterial Function in Human Type 2 Diabetic Patients
2005
Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals.
1991
Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.
1996
Molecular Coproscopy: Dung and Diet of the Extinct Ground Sloth Nothrotheriops shastensis
1998 StandoutScienceNobel
Chemical Glycobiology
2001 StandoutScienceNobel
Functional Polymorphisms of UCP2 and UCP3 Are Associated With a Reduced Prevalence of Diabetic Neuropathy in Patients With Type 1 Diabetes
2006
Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis
2004
Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells
2002
Hyperglycemia Potentiates Collagen-Induced Platelet Activation Through Mitochondrial Superoxide Overproduction
2001
The breakdown of pre‐existing advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes
2003
The Pathobiology of Diabetic Complications
2005 Standout
Cell Surface Engineering by a Modified Staudinger Reaction
2000 StandoutScienceNobel
Rous-Whipple Award Lecture. Atherosclerosis: a defense mechanism gone awry.
1993
Oxidative Stress and Diabetic Complications
2010 Standout
A chemical approach for identifying O -GlcNAc-modified proteins in cells
2003 StandoutNobel
Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration
2011
Diabetes Complications: Why Is Glucose Potentially Toxic?
1996 Science
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
2006
Altered proliferation of retinal microvascular cells on glycated matrix.
1995
Protein Modification by O-Linked GlcNAc Reduces Angiogenesis by Inhibiting Akt Activity in Endothelial Cells
2008
Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats.
1997
Advanced glycation end products in vitreous: Structural and functional implications for diabetic vitreopathy.
1998
Investigating Cellular Metabolism of Synthetic Azidosugars with the Staudinger Ligation
2002 StandoutNobel
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
2003 StandoutNobel
Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling
1988 Science
Activation of Receptor for Advanced Glycation End Products
1999
ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING
1995
Mechanisms of Diabetic Complications
2013 Standout
Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy
1998
Understanding RAGE, the receptor for advanced glycation end products
2005
Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides
2003 StandoutNobel
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase
2003
Imaging the glycome
2008 StandoutNobel
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy
2006
Glucosamine-Induced Endoplasmic Reticulum Dysfunction Is Associated With Accelerated Atherosclerosis in a Hyperglycemic Mouse Model
2006
Uncoupling Proteins Prevent Glucose-Induced Neuronal Oxidative Stress and Programmed Cell Death
2004
Acid−Base Controllable Molecular Shuttles
1998 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins.
1991
Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?
2003
Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia
2002
Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.
1992
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
Advanced Glycosylation End Products Up-Regulate Connective Tissue Growth Factor (Insulin-Like Growth Factor-Binding Protein-Related Protein 2) in Human Fibroblasts: A Potential Mechanism for Expansion of Extracellular Matrix in Diabetes Mellitus*
2001
THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE
2005
Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi‐mutated herpes simplex virus type‐1 (G207)
1999
Diabetic Nephropathy Is Associated With Gene Expression Levels of Oxidative Phosphorylation and Related Pathways
2006
Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus
2011
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Identification of Galectin-3 As a High-Affinity Binding Protein for Advanced Glycation End Products (AGE): A New Member of the AGE-Receptor Complex
1995
Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells
1997
Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells
2004
Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the Risk of Future 10-Year Progression of Diabetic Retinopathy and Nephropathy in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications Participants With Type 1 Diabetes
2005
Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy.
1991
Benfotiamine Counteracts Glucose Toxicity Effects on Endothelial Progenitor Cell Differentiation via Akt/FoxO Signaling
2006
Surface molecular recognition
2001 StandoutNobel
Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis
1997 StandoutScienceNobel
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Glyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic Complications
1994
Delayed Treatment with Aminoguanidine Decreases Focal Cerebral Ischemic Damage and Enhances Neurologic Recovery in Rats
1998
The effect of nonenzymatic glucosylation on the binding of the main noncollagenous NC1 domain to type IV collagen.
1988
Works of M. Brownlee being referenced
Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide
2005
Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product N e -(carboxymethyl) lysine independently of glycohaemoglobin concentrations
1999
The pathological implications of protein glycation.
1995
Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon.
1997
Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells
2004
Secondary intervention with aminoguanidine retards the progression of diabetic retinopathy in the rat model
1995
Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes
2008
Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
2010
Differential accumulation of advanced glycation end products in the course of diabetic retinopathy
1999
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
2001
Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology
2011
Aminoguanidine does not inhibit the initial phase of experimental diabetic retinopathy in rats
1995
Glycosylation Products as Toxic Mediators of Diabetic Complications
1991
BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.
1996
Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats
1992
Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes
2003
Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat
1994
Nonenzymatic glycosylation products on collagen covalently trap low-density lipoprotein
1985
Nonenzymatic glycosylation: role in the pathogenesis of diabetic complications.
1986
Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat.
1998
High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules.
1985
Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors.
1986
Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy.
1991
Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking
1986 Science
Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine
1992
Specific macrophage receptor activity for advanced glycosylation end products inversely correlates with insulin levels in vivo
1988
Trapped immunoglobulins on peripheral nerve myelin from patients with diabetes mellitus
1986
Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen.
1992
The Biochemistry of the Complications of Diabetes Mellitus
1981
Advanced glycosylation endproducts on erythrocyte cell surface induce receptor-mediated phagocytosis by macrophages. A model for turnover of aging cells.
1987
Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.
1998