Standout Papers

High serum procalcitonin concentrations in patients with sepsis and infection 1993 2026 2004 2015 1.6k
  1. High serum procalcitonin concentrations in patients with sepsis and infection (1993)
    M. Assicot, Claude Bohuon et al. The Lancet

Citation Impact

Citing Papers

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19
2020 Standout
Infection, inflammation, height, and longevity
2005 Standout
Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society
2016 Standout
Systematic review and meta-analysis of the diagnostic accuracy of procalcitonin, C-reactive protein and white blood cell count for suspected acute appendicitis
2012
Procalcitonin as a marker of bacterial infection in the emergency department: an observational study
2003
Impact of interleukin-10, soluble CD25 and interferon-γ on the prognosis and early diagnosis of bacteremic systemic inflammatory response syndrome: a prospective observational study
2013
Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit
2002
Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction
2004
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
2022 StandoutNobel
Biomarkers of sepsis
2006
Relationship between procalcitonin plasma levels and severity of injury, sepsis, organ failure, and mortality in injured patients
2000
Procalcitonin and interleukin‐6 in the diagnosis of early‐onset sepsis of the neonate
2003
Procalcitonin and neopterin as indicators of infection in critically ill patients
2002
Amino acid imbalance early in septic encephalopathy
2002
Sepsis biomarkers: a review
2010 Standout
Procalcitonin used as a marker of infection in the intensive care unit
1999
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
2020 Standout
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
2001 Standout
QM/MM Methods for Biomolecular Systems
2009 Standout
Is Caregiving Hazardous to One's Physical Health? A Meta-Analysis.
2003 Standout
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
2004 Standout
PROGNOSTIC VALUE OF INTERLEUKIN 6, PROCALCITONIN, AND C-REACTIVE PROTEIN LEVELS IN INTENSIVE CARE UNIT PATIENTS DURING FIRST INCREASE OF FEVER
2006
Semi-quantitative Procalcitonin Test for the Diagnosis of Bacterial Infection: Clinical Use and Experience in Japan
2010
Outcome Prediction by Traditional and New Markers of Inflammation in Patients with Sepsis
1999
Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis
2013 Standout
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients
2007
Usefulness of procalcitonin for diagnosis of infection in cardiac surgical patients
2000
Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis, severe sepsis, and septic shock
2006
Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial
2004
Detection of Acute Phase Response and Infection. The Role of Procalcitonin and C-Reactive Protein
1999
Biomarkers of sepsis
2009
Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery
2005
Procalcitonin and cytokine levels: Relationship to organ failure and mortality in pediatric septic shock
2000
Procalcitonin in children admitted to hospital with community acquired pneumonia
2001
Procalcitonin (PCT) in cardiac surgery: diagnostic value in systemic inflammatory response syndrome (SIRS), sepsis and after heart transplantation (HTX)
2000
Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis
2005 Standout
Melioidosis
2012 Standout
Shock, inflammation and PARP
2005
Procalcitonin assay in systemic inflammation, infection, and sepsis: Clinical utility and limitations
2008
Assessment of procalcitonin as a diagnostic and prognostic marker in patients with solid tumors and febrile neutropenia
2004
Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial
2015 StandoutNobel
Comparison of procalcitonin and C-reactive protein as markers of sepsis
2003
Procalcitonin and C-Reactive Protein Levels in Community-Acquired Pneumonia: Correlation with Etiology and Prognosis
2000
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
2013 Standout
Oxidative stress in septic shock and disseminated intravascular coagulation
2002
Procalcitonin in fever of unknown origin after liver transplantation: A variable to differentiate acute rejection from infection
2000
Severe Sepsis and Septic Shock
2013 Standout
Diagnostic and Prognostic Values of Admission Procalcitonin Levels in Community–Acquired Pneumonia in an Intensive Care Unit
2005
Catecholaminergic suppression of immunocompetent cells
1998
Combination of biphasic transmittance waveform with blood procalcitonin levels for diagnosis of sepsis in acutely ill patients
2008
Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis-related cytokines in vitro
1999
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
IL-6 as a keystone cytokine in health and disease
2015 Standout
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
Antibacterial resistance worldwide: causes, challenges and responses
2004 Standout
C-reactive protein as a marker of infection in critically ill patients
2005
Procalcitonin — A new indicator of the systemic response to severe infections
1997
Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit
2000
Procalcitonine et méningites virales : réduction des traitements antibiotiques inutiles par le dosage en routine au cours d’une épidémie
2002
Diagnostic markers of infection: comparison of procalcitonin with C reactive protein and leucocyte count
1999
Postoperative plasma concentrations of procalcitonin after different types of surgery
1998
Decrease of serum dipeptidylpeptidase activity in severe sepsis patients: relationship to procalcitonin
2002
Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro
2000
Synthesis and Release of Dopamine in Rat Brain: Comparison Between Substantia Nigra Pars Compacta, Pars Reticulata, and Striatum
1989 StandoutNobel
Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study
2006
Usefulness of Procalcitonin as a Marker of Systemic Infection in Emergency Department Patients: A Prospective Study
2002
Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management
2015 Standout
Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections
1999
Sepsis and septic shock
2018 Standout
The Clinical Value of Procalcitonin and Neopterin in Predicting Sepsis and Organ Failure After Major Trauma
2003
EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT
2009
Polyphenols: food sources and bioavailability
2004 Standout
Serum procalcitonin levels in bacterial and abacterial meningitis
2000
C-reactive protein: a valuable marker of sepsis
2002
Procalcitonin in preoperative diagnosis of abdominal sepsis
2007
Early increase of procalcitonin after cardiovascular surgery in patients with postoperative complications
2002
Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome
2005
Fièvre et tumeur solide : valeur diagnostique de la procalcitonine et de la protéine C réactive
2001
Should procalcitonin be introduced in the diagnostic criteria for the systemic inflammatory response syndrome and sepsis?
2004
Purification methods of mammalian catechol-O-methyltransferases
1996
Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
2007
Myocarditis
2000 Standout
CLINICAL TRIALS FOR SEVERE SEPSIS
1999
Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine
2003
Serum Calcitonin Precursors in Sepsis and Systemic Inflammation1
1998
The Pathophysiology and Treatment of Sepsis
2003 Standout
Valor de la determinación de la proteína C reactiva como marcador pronóstico y de infección en pacientes críticos
2005
Reliability of Procalcitonin Concentrations for the Diagnosis of Sepsis in Critically III Neonates
1998
Can procalcitonin help identify associated bacterial infection in patients with severe influenza pneumonia? A multicentre study
2011
Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6
2000
Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
2010 Standout
Hyperprocalcitonemia in Patients with Noninfectious SIRS and Pulmonary Dysfunction Associated with Cardiopulmonary Bypass 
1998
The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function
2001
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
2003 Standout
Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock
2012
Usefulness of procalcitonin and C-reactive protein rapid tests for the management of children with urinary tract infection
2001
The immunopathology of sepsis and potential therapeutic targets
2017 Standout
Procalcitonin—a sepsis parameter in severe burn injuries
1998
Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis
2006
Circulating endothelin-1 and tumor necrosis factor-α: early predictors of mortality in patients with septic shock
2000
Plasma procalcitonin and C-reactive protein in acute septic shock: Clinical and biological correlates
2002
Endotoxin and immune activation in chronic heart failure: a prospective cohort study
1999
Procalcitonin: a marker to clearly differentiate systemic inflammatory response syndrome and sepsis in the critically ill patient?
2002
Comparison of Procalcitonin, sCD14 and Interleukin-6 Values in Septic Patients
2000
Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin
2001
Origin of noradrenergic innervation of the spleen in rats
1989
Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
2002
Sensitivity and specificity of various markers of inflammation for the prediction of tumor necrosis factor-α and interleukin-6 in patients with sepsis
1999
Is nitric oxide overproduction the target of choice for the management of septic shock?
2001
Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis
2004 Standout
Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
2001
Discriminative Value of Inflammatory Biomarkers for Suspected Sepsis
2011
Procalcitonin in the diagnosis of inflammation in intensive care units
2006
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine
2014 Standout
Hemodynamic monitoring in shock and implications for management
2007
High Sensitivity and Specificity of Serum Procalcitonin Levels in Adults with Bacterial Meningitis
1999
Inducible nitric oxide synthase gene knockout mice have increased resistance to gut injury and bacterial translocation after an intestinal ischemia-reperfusion injury
2000
Endotoxin, Cytokines, and Procalcitonin in Febrile Patients Admitted to the Hospital: Identification of Subjects at High Risk of Mortality
2000
Procalcitonin Kinetics as a Prognostic Marker of Ventilator-associated Pneumonia
2004
Diagnostic Value of Procalcitonin, Interleukin-6, and Interleukin-8 in Critically Ill Patients Admitted with Suspected Sepsis
2001
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
2012 Standout
Medullary Thyroid Cancer: Management Guidelines of the American Thyroid Association
2009 Standout
Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management
2015 Standout
New Approaches to Sepsis: Molecular Diagnostics and Biomarkers
2012
New isoflavones, inhibiting catechol-O-methyltransferase, produced by Streptomyces.
1975
Acinetobacter baumannii : Emergence of a Successful Pathogen
2008 Standout
Reliability of Procalcitonin as a Severity Marker in Critically Ill Patients with Inflammatory Response
2002
Christian Raetz: Scientist and Friend Extraordinaire
2013 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes:  Applications to Drug Design
1997 Standout
Assessment of Clinical Criteria for Sepsis
2016 Standout
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
Serpin Structure, Mechanism, and Function
2002 Standout
Procalcitonin: THE marker of sepsis?
2000
Melioidosis: Epidemiology, Pathophysiology, and Management
2005 Standout
Current concepts in the diagnosis and management of cytokine release syndrome
2014 Standout
Kinetic Analysis of the Zinc-Dependent Deacetylase in the Lipid A Biosynthetic Pathway
2005
Evaluation of Neutrophil CD64 Expression and Procalcitonin as Useful Markers in Early Diagnosis of Sepsis
2008
Postoperative plasma concentrations of procalcitonin after different types of surgery
1998
Plasma Level of a Triggering Receptor Expressed on Myeloid Cells-1: Its Diagnostic Accuracy in Patients with Suspected Sepsis
2004
Procalcitonin: A Marker of Bacteraemia in SIRS
2003
Pneumonitis-Associated Hyperprocalcitoninemia
1996
Prediction of Microbial Infection and Mortality in Medical Patients with Fever: Plasma Procalcitonin, Neutrophilic Elastase‐α‐Antitrypsin, and Lactoferrin Compared with Clinical Variables
1999
Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
2011 StandoutScience
Refined Solution Structure of the LpxC−TU-514 Complex and pKa Analysis of an Active Site Histidine:  Insights into the Mechanism and Inhibitor Design,
2005
Deactivation of Norepinephrine by Peroxynitrite as a New Pathogenesis in the Hypotension of Septic Shock
2003
Pathophysiology of polytrauma
2005
Toward Resolving the Challenges of Sepsis Diagnosis
2004
Recent Advances in Zinc Enzymology
1996 Nobel
Diagnostic Efficacy and Prognostic Value of Serum Procalcitonin Concentration in Patients With Suspected Sepsis
2008
Role of infection and antimicrobial therapy in acute exacerbations of chronic obstructive pulmonary disease
2006
Noradrenaline: Fate and Control of Its Biosynthesis
1971 ScienceNobel
Isolation and characterization of a novel human pancreas-specific gene,pancpin, that is down-regulated in pancreatic cancer cells
1998
Diagnostic and prognostic value of procalcitonin in patients with septic shock
2004
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
2000 Standout
Pneumonitis-Associated Hyperprocalcitoninemia
1996
Peptide Hydrolysis in Thermolysin:  Ab Initio QM/MM Investigation of the Glu143-Assisted Water Addition Mechanism
2007
Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo.
2001
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Practice Guidelines for the Management of Bacterial Meningitis
2004 Standout
Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock
2012 Standout
Immunohistochemical demonstration of catechol-O-methyltransferase in mammalian brain
1979
Procalcitonin as an Acute Phase Marker
2001
Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS
1999
Serum procalcitonin and C‐reactive protein in children with diarrhoea of various aetiologies
2004
Early identification of bacteremia by biochemical markers of systemic inflammation
2001
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
2013
Uridine-Based Inhibitors as New Leads for Antibiotics Targeting Escherichia coli LpxC
2009 StandoutNobel
Proton-Coupled Electron Transfer
2012 Standout
Procalcitonin correlates with C-reactive protein as an acute-phase reactant in pediatric patients.
2000
La procalcitonine (PCT) est-elle le marqueur spécifique du choc septique ?
2003

Works of M. Assicot being referenced

Serum procalcitonin concentrations in acute malaria
1994
Elevated Serum Procalcitonin Levels in Patients with Melioidosis
1995
High serum procalcitonin concentrations in patients with sepsis and infection
1993 Standout
Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations
1997
Procalcitonin release patterns in a baboon model of trauma and sepsis: Relationship to cytokines and neopterin
2000
Measurement of Procalcitonin Levels in Children with Bacterial or Viral Meningitis
1997
Procalcitonin (PCT) is useful in predicting the bacterial origin of an acute circulatory failure in critically ill patients
2000
The Role of Histidine 231 in Thermolysin-like Enzymes.
1995
Procalcitonin as a marker for the early diagnosis of neonatal infection
1996
Procalcitonin as a marker of bacterial sepsis in patients infected with HIV-1
1997
POSSIBLE ROLE OF TNF ON PROCALCITONIN RELEASE IN A BABOON MODEL OF SEPSIS
2001
Presence of two distinct catechol -O- methyltransferase activities in red blood cells
1971
[Procalcitonin in severe trauma].
1998
Procalcitonin Is a Marker of Severity of Renal Lesions in Pyelonephritis
1998
Purification and Studies of Catechol‐O‐Methyltransferase of Rat Liver
1970
183 Procalcitonin Concentrations in Pleural Effusion as a Marker of Human Septic Response
1995
[Procalcitonin, a marker of bacterial meningitis in children].
1998
[Procalcitonin, C-reactive protein and interleukin 6 in bacterial and viral meningitis in children].
1998
Catechol-O-methyltransferase activity and aminergic binding sites distribution in human peripheral blood lymphocyte subpopulations
1983
Procalcitonin increase after endotoxin injection in normal subjects.
1994
Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome
1998
Production of antibodies to catechol-O-methyltransferase (EC 2.1.1.6) of rat liver
1969
Étude de l'immunoréactivité calcitonin-likeau cours des processus infectieux
1994
Changes in procalcitonin and interleukin 6 levels among treated African patients with different clinical forms of malaria
1997
Rankless by CCL
2026