Standout Papers
Citation Impact
Citing Papers
Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines
2007 StandoutNobel
Palladium‐Catalyzed Cross‐Coupling Reactions in Total Synthesis
2005 Standout
Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract
2004
Inhibition of DNA Biosynthesis in HeLa Cells by Cytotoxic and Antitumor Sesquiterpene Lactones
1981
Biological activities of sesquiterpene lactones
1986 Standout
Cancer chemoprevention with dietary phytochemicals
2003 Standout
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
XPB, a subunit of TFIIH, is a target of the natural product triptolide
2011 Standout
Purification, crystallization, and preliminary x-ray diffraction analysis of an M.HhaI-AdoMet complex
1992 StandoutNobel
Chemistry, Biochemistry, and Safety of Acrylamide. A Review
2003 Standout
What made sesquiterpene lactones reach cancer clinical trials?
2010 Standout
Use of self-organizing maps and molecular descriptors to predict the cytotoxic activity of sesquiterpene lactones
2008
Linking tumor cell cytotoxicity to mechanism of drug action: An integrated analysis of gene expression, small‐molecule screening and structural databases
2005
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
The biochemistry and medical significance of the flavonoids
2002 Standout
NF-κB and IKK as therapeutic targets in cancer
2006 Standout
Advances in flavonoid research since 1992
2000 Standout
Helenanolide-type sesquiterpene lactones—III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules
1997
Phosphine-triggered synthesis of functionalized cyclic compounds
2008 Standout
A biologically active lipophilic flavonol from Tanacetum parthenium
1995
Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolate
1990
Quantitative structure–activity relationship of sesquiterpene lactones with cytotoxic activity
2007
Design and Enantioselective Synthesis of Cashmeran Odorants by Using “Enol Catalysis”
2015 StandoutNobel
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase
2004 Nature
An NMR Spectroscopic Method to Identify and Classify Thiol‐Trapping Agents: Revival of Michael Acceptors for Drug Discovery?
2010
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
2006 Standout
Inhibition of elongation growth by two sesquiterpene lactones isolated from Helianthus annuus L.
1982
Iron-Catalyzed Reactions in Organic Synthesis
2004 Standout
Sesquiterpene lactones from Podanthus ovatifolius
1973
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
2002 Standout
Antifungal activity of helenin and isohelenin
1983
Selective Alkylation: A Biomimetic Reaction of the Antileukemic Triptolides?
1974 Science
Toxicity and mutagenicity of hymenoxon, a sequiterpene lactone
1981
Novel and selective α-substitution of ketones and other carbonyl compounds based on Pd-catalyzed cross coupling of α,β-unsaturated carbonyl derivatives containing α-halogen or α-metal groups
1999 StandoutNobel
Role of Nrf2 in Oxidative Stress and Toxicity
2013 Standout
The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65
1998 Standout
Natural Product Synthesis Using Multicomponent Reaction Strategies
2009 Standout
The Preparation and Properties of Gel-Filtered Rabbit-Reticulocyte Lysate Protein-Synthesis Systems
1983 StandoutNobel
Method for the Parallel Synthesis of α-Methylene-γ-lactones from a Fluorous Acrylate
2006
Regiospecific michael additions to α-methylene cyclopentenones
1984
Glutathione. 8. The effects of glutathione disulfide on initiation of protein synthesis.
1972
Synthesis and Antiproliferative Activity of a New Compound Containing an α-Methylene-γ-Lactone Group
2002
Calculating Structures and Free Energies of Complex Molecules: Combining Molecular Mechanics and Continuum Models
2000 Standout
Antitumor Agents XXX: Evaluation of α-methylene-γ-lactone-Containing Agents for Inhibition of Tumor Growth, Respiration, and Nucleic Acid Synthesis
1978
Specific binding of phorbol ester tumor promoters
1980 Standout
Quantitative Structure−Activity Relationship of Sesquiterpene Lactones as Inhibitors of the Transcription Factor NF-κB
2004
Synthesis, crystal structure, theoretical calculation and cytotoxic effect of new Pt(ii), Pd(ii) and Cu(ii) complexes with pyridine-pyrazoles derivatives
2008
Induction of deoxyribonucleic acid damage in HeLa S3 cells by cytotoxic and antitumor sesquiterpene lactones
1981
Phosphine Organocatalysis
2018 Standout
Antibiotics from basidiomycetes
1981
Susceptibility of Cholangiocarcinoma Cells to Parthenolide-Induced Apoptosis
2005
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
2001
The formation of novel 1,3-dioxolanes: atypical Baylis–Hillman reaction of a sesquiterpene lactone parthenin
2007
Molluscicidal activity of sesquiterpene lactones
1984
Free-Radical Carbon-Carbon Bond Formation in Organic Synthesis
1984 Science
Theoretical Studies Suggest a New Antifolate as a More Potent Inhibitor of Thymidylate Synthase
2000
Sesquiterpenoids Lactones: Benefits to Plants and People
2013 Standout
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Electrophilicity Index
2006 Standout
Bakkenolide-A. Its distribution in Petasites species and cytotoxic properties
1976
Deterrent activity of sesquiterpene lactones from the umbelliferae against storage pests
1983
Conversion of Parthenin to Anhydroparthenin Using Microwave Irradiation
1999
Rapid Methylation for the Synthesis of a 11C-Labeled Tolylisocarbacyclin Imaging the IP2 Receptor in a Living Human Brain
2000 StandoutNobel
Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action
1999
Sulferalin, a novel sulfonyl pseudoguaianolide sesquiterpene lactone from Sendai Helenium autumnale L.
1977
Zanvil Alexander Cohn 1926-1993.
1994 StandoutNobel
Structure d'une lactone allergisante: Le frullanolide—I
1972
Olefin Metathesis and Beyond
2000 Standout
A direct, highly convergent route to α-methylene-γ-lactones fused to medium and large rings
1999
Inactivation of glycogen synthase by the tumor inhibitor vernolepin
1972
Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione
1979
One-pot synthesis of functionalized furamide derivatives via a three-component reaction between an amine, diketene and dibenzoylacetylene in the presence of triphenylphosphine
2007
The structural relationship of phorbol and cortisol: A possible mechanism for the tumor promoting activity of phorbol
1976
Baylis–Hillman chemistry: synthesis of cis- and trans-α-methylene-γ-lactones
2006
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
2005 Standout
Synthesis, preliminary cytotoxicity evaluation of new 3-formylchromone hydrazones and phosphorohydrazone derivatives of coumarin and chromone
2011
GLUTATHIONE TRANSFERASES
2004 Standout
Lewis Acid Induced α‐Alkylation of Carbonyl Compounds
1982
Glutathione
1972
Structure‐activity aspects of 4 allergenic sesquiterpene lactones tacking the exocyclic α‐methylene at the lactone ring
1985
Chemoprophylactic agents in schistosomiasis: eremanthine, costunolide, α-cyclocostunolide and bisabolol
1972
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Biological activities of sesquiterpene lactones
1976 Standout
ETHNOPHARMACOLOGY OF MEXICAN ASTERACEAE (COMPOSITAE)
1998
Structure−Cytotoxicity Relationships of Some Helenanolide-Type Sesquiterpene Lactones
1997
Allergic Contact Dermatitis Caused by Artemisia and Chrysanthemum Species
1971
Dietary Carcinogens and Anticarcinogens
1983 StandoutScience
New synthetic reactions of allyl alkyl carbonates, allyl .beta.-keto carboxylates, and allyl vinylic carbonates catalyzed by palladium complexes
1987
Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics.
1983
Synthetic potential of the tertiary-amine-catalysed reaction of activated vinyl carbanions with aldehydes
1988 Standout
Antimicrobial activity of the heliangolide chromolaenide and related sesquiterpene lactones
1980
Triterpene Biosynthesis in Plants
2014 Standout
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
2000 Standout
Helenanolide type sesquiterpene lactones Part 1. Conformations and molecular dynamics of helenalin, its esters and 11,13-dihydro derivatives
1996
Biological activity of vernoflexuoside on the basis ofAllium test
1976
Microwave assisted organic synthesis—a review
2001 Standout
Chemical and biochemical modifications of parthenin
1999
Antitumor Agents XLI: Effects of Eupaformosanin on Nucleic Acid, Protein, and Anaerobic and Aerobic Glycolytic Metabolism of Ehrlich Ascites Cells
1980
Advances in the Baylis–Hillman reaction-assisted synthesis of cyclic frameworks
2008 Standout
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Anti-Inflammatory Activity of Sesquiterpene Lactones and Related Compounds
1979
Expeditious synthesis of 3-arylidenelactams and 3-arylidenelactones from N-tosylaziridine derivatives
2007
Mutagenic activity of hymenovin in Salmonella typhimurium: Association with the bishemiacetal functional group
1978
Sesquiterpene Antitumor Agents: Inhibitors of Cellular Metabolism
1977 Science
Synthesis of 4‐[(1,3‐diaminopyrrolo[3′,4′:4,5]pyrido[2,3‐d]‐pyrimidin‐8‐yl)benzoyl]‐L‐glutamic acid as a potential antifolate
1993
Synthesis of α-Methylene-γ-Butyrolactones
1975
Antineoplastic agents 32. The pseudoguaianolide helenalin
1973
The C-H.cntdot..cntdot..cntdot.O hydrogen bond in crystals: what is it?
1991 Standout
The Essential Medicinal Chemistry of Curcumin
2017 Standout
Inhibition of Phosphofructokinase by Quinone Methide and α-Methylene Lactone Tumor Inhibitors
1970 Science
Recent Advances in the Baylis−Hillman Reaction and Applications
2003 Standout
The effect of cyclic AMP and related compounds on the control of protein synthesis in reticulocyte lysates
1974 StandoutNobel
Hydrogen peroxide from cellular metabolism of cystine. A requirement for lysis of murine tumor cells by vernolepin, a glutathione-depleting antineoplastic.
1985
Chemical Implications for Antitumor and Antiviral Prostaglandins: Reaction of Δ7-Prostaglandin A1 and Prostaglandin A1 Methyl Esters with Thiols
1997 StandoutNobel
Works of M. Allan Eakin being referenced
Quinuclidine Inhibitors of 2,3-Oxidosqualene Cyclase-Lanosterol Synthase: Optimization from Lipid Profiles
1999
Reactions of Alpha Methylene Lactone Tumor Inhibitors with Model Biological Nucleophiles
1970 Science
Tumor inhibitors. LVII. Reaction of endocyclic .alpha.,.beta.-unsaturated .gamma.-lactones with thiols
1970
Tumor inhibitors. 69. Structure-cytotoxicity relations among the sesquiterpene lactones
1971 Standout
Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent
1985