Citation Impact
Citing Papers
Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
2013 Science
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
2014
2014
Ubiquitin Ligases: Structure, Function, and Regulation
2017
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
2014
Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
2013
Phospholipid methylation controls Atg32‐mediated mitophagy and Atg8 recycling
2015 StandoutNobel
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation
2015 StandoutNobel
Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy
2014
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
2012
A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment
2013
Loss of iron triggers PINK1/Parkin‐independent mitophagy
2013
A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
2013
The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
2015
Parkinson disease
2017 Standout
Autophagy in infection, inflammation and immunity
2013 Standout
Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells and Drosophila*
2013
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
2015
Mechanism and medical implications of mammalian autophagy
2018 Standout
Cargo recognition and degradation by selective autophagy
2018
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism
2013
The role of autophagy in neurodegenerative disease
2013 Standout
Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis
2012
Ubiquitin is phosphorylated by PINK1 to activate parkin
2014 Nature
Obligate biotroph parasitism: can we link genomes to lifestyles?
2012
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
Select E2 enzymes differentially regulate parkin activation and mitophagy
2014
Parkin and mitochondrial quality control: toward assembling the puzzle
2014
Ageing as a risk factor for neurodegenerative disease
2019 Standout
TRAP1 rescues PINK1 loss-of-function phenotypes
2013
Self and Nonself: How Autophagy Targets Mitochondria and Bacteria
2014
Candida albicanspathogenicity mechanisms
2013 Standout
Tau in physiology and pathology
2015 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
100 years of Lewy pathology
2012
Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy
2013
The role of iron and reactive oxygen species in cell death
2013 Standout
Tissue Kallikrein Inhibitors Based on the Sunflower Trypsin Inhibitor Scaffold – A Potential Therapeutic Intervention for Skin Diseases
2016 StandoutNobel
Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering
2014
Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses
2015
Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme
2011
Parkinson's disease
2015 Standout
The pharmacological regulation of cellular mitophagy
2017
Drug repurposing: progress, challenges and recommendations
2018 Standout
Deciphering the Molecular Signals of PINK1/Parkin Mitophagy
2016
PINK1/Parkin-mediated mitophagy in mammalian cells
2015
PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions
2014
Fluorescence nanoscopy in cell biology
2017 StandoutNobel
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
2013 Nature
UBE2N, UBE2L3 and UBE2D2/3 ubiquitin-conjugating enzymes are essential for parkin-dependent mitophagy
2014
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
2014
An emerging role of PARK2 in cancer
2013
Parkin and mitophagy in cancer
2016
Presenting your structures: theCCP4mgmolecular-graphics software
2011
Signaling Mechanisms in Pattern-Triggered Immunity (PTI)
2015 Standout
Evaluation of the Role of Candida albicans Agglutinin-Like Sequence (Als) Proteins in Human Oral Epithelial Cell Interactions
2012
The PI3K Pathway in Human Disease
2017 Standout
Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates
2016 StandoutNobel
PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila
2014
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin
2017
Structure of the human Parkin ligase domain in an autoinhibited state
2013
Fusobacterium nucleatum — symbiont, opportunist and oncobacterium
2018 Standout
Models of α-synuclein aggregation in Parkinson’s disease
2014
How Mitochondrial Dynamism Orchestrates Mitophagy
2015
Organellophagy: Eliminating cellular building blocks via selective autophagy
2014
Pathophysiology of Type 2 Diabetes Mellitus
2020 Standout
Spermidine in health and disease
2018 StandoutScience
Ubiquitin and Parkinson's disease through the looking glass of genetics
2017
Shuttling of PINK1 between Mitochondrial Microcompartments Resolved by Triple-Color Superresolution Microscopy
2015
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
2013
Phosphorylated ubiquitin chain is the genuine Parkin receptor
2015
Oxidative stress, mitochondrial damage and neurodegenerative diseases.
2013 Standout
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
2013
Cellular Components Mediating Coadherence of Candida albicans and Fusobacterium nucleatum
2015
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension
2012
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
2019 Standout
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
2018 Standout
Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions
2012
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
2014
Analog sensitive chemical inhibition of the DEAD ‐box protein DDX 3
2015 StandoutNobel
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
2014
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
2019 Standout
PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy
2016
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
2015
Works of Lynn Burchell being referenced
Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans
2011
A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
2013
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
2012
The structure of the genomicBacillus subtilisdUTPase: novel features in the Phe-lid
2010
Autoregulation of Parkin activity through its ubiquitin‐like domain
2011
Small, N-Terminal Tags Activate Parkin E3 Ubiquitin Ligase Activity by Disrupting Its Autoinhibited Conformation
2012