Citation Impact
Citing Papers
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
2010 StandoutScience
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Roles of tau protein in health and disease
2017
Developmental neurotoxicity of industrial chemicals
2006 Standout
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis
2003
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease
2007
Determinants of Nuclear and Cytoplasmic Ubiquitin-mediated Degradation of MyoD
2003 StandoutNobel
Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination
2003 StandoutNobel
Treatment Strategies Targeting Amyloid -Protein
2012
A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1
2003 StandoutNobel
Alternative isoform regulation in human tissue transcriptomes
2008 StandoutNature
Ubiquitin-Proteasome-mediated Degradation of Id1 Is Modulated by MyoD
2004 StandoutNobel
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors
2007
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
The role of autophagy in neurodegenerative disease
2013 Standout
Huntington's disease
2007 Standout
A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice
2016
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
2010
Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
2003 Standout
Cognitive Dysfunction Precedes Neuropathology and Motor Abnormalities in the YAC128 Mouse Model of Huntington's Disease
2005
Memory formation and retention are affected in adult miR-132/212 knockout mice
2015
SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning
2010 StandoutNobel
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
2009 Standout
Cell Death
2004 Standout
The controls of eating: a shift from nutritional homeostasis to behavioral neuroscience
2000
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Metazoan MicroRNAs
2018 Standout
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Cognitive deficits and associated neurological complications in individuals with Down's syndrome
2010
Revealing Global Regulatory Features of Mammalian Alternative Splicing Using a Quantitative Microarray Platform
2004
Visualizing Sexual Dimorphism in the Brain
2004 StandoutNobel
Behavioural study of the -galactose induced aging model in C57BL/6J mice
2004 Standout
Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination
2004 StandoutNobel
Molecular mechanisms of caspase regulation during apoptosis
2004 Standout
Environmental enrichment reduces the mnemonic and neural benefits of estrogen
2004
Alzheimer's Disease
2010 Standout
The ubiquitin system: pathogenesis of human diseases and drug targeting
2004 StandoutNobel
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
2008 Standout
Obesity and the Regulation of Energy Balance
2001 Standout
Down's syndrome
2003 Standout
Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease
2011
The Tumor Suppressor Protein p16 and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System
2004 StandoutNobel
A network dysfunction perspective on neurodegenerative diseases
2006 Nature
The amyloid state and its association with protein misfolding diseases
2014 Standout
A γ‐secretase inhibitor decreases amyloid‐β production in the central nervous system
2009
The ubiquitin system
2000 StandoutNobel
Caspase Activation Inhibits Proteasome Function during Apoptosis
2004 StandoutNobel
Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
2011
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators
2005 Nature
Iron Catalysis in Organic Synthesis
2015 Standout
Synthesis of Sulfones by Iron‐Catalyzed Decomposition of Sulfonylhydrazones
2011
Down Syndrome
2020 Standout
The Golden Age of Transfer Hydrogenation
2015 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators
2012
Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion
2001
Ruthenium(II) Complexes Bearing a Pyridyl-Supported Pyrazolyl−N-Heterocyclic Carbene (NNC) Ligand and Their Catalytic Activity in the Transfer Hydrogenation of Ketones
2008
A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits.
2002
Oxadiazoles in Medicinal Chemistry
2011 Standout
Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes
2018 StandoutNobel
N-Heterocyclic Carbenes in Late Transition Metal Catalysis
2009 Standout
An Essential Role of N-Terminal Arginylation in Cardiovascular Development
2002 Science
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
A Model System for Study of Sex Chromosome Effects on Sexually Dimorphic Neural and Behavioral Traits
2002
The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules
2016
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
BACE inhibitors in clinical development for the treatment of Alzheimer’s disease
2018
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
RGS4 and RGS5 are in vivo substrates of the N-end rule pathway
2005
Quality control in the endoplasmic reticulum
2003 Standout
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
2000 Standout
Completely N1-Selective Palladium-Catalyzed Arylation of Unsymmetric Imidazoles: Application to the Synthesis of Nilotinib
2011
Works of Lynn A. Hyde being referenced
Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators
2010
Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability
2009
Water version of the radial-arm maze: Learning in three inbred strains of mice
1998
Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse
2006
Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease
2006
Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice
2005
Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein
2003
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology
2015
Tricyclic sulfones as orally active γ-secretase inhibitors: Synthesis and structure–activity relationship studies
2010
Motor learning in Ts65Dn mice, a model for Down syndrome
2000
Working memory deficits in BXSB mice with neocortical ectopias
2000
Increased seizure threshold and severity in young transgenic CRND8 mice
2004
Differential learning strategies in spatial and nonspatial versions of the Morris water maze in the C57BL/6J inbred mouse strain
2002
Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
2001
Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators
2011
Spatial ability of XY sex-reversed female mice
2000
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors
2007
Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment
1996
The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators
2010
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage
2017
Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway
2000
Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease.
2001