Citation Impact
Citing Papers
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
2012 StandoutScience
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
2009
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Phospholipid methylation controls Atg32‐mediated mitophagy and Atg8 recycling
2015 StandoutNobel
Immunotherapy of cancer in 2012
2012
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
2015 StandoutNobel
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Physiological functions of the HECT family of ubiquitin ligases
2009
Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8+ effector T cell responses
2016
Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
2012
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
2013
Autophagosomes form at ER–mitochondria contact sites
2013 StandoutNature
The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
2010
Identification and characterization of a loss-of-function human MPYS variant
2011
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
2013
Necroptosis and its role in inflammation
2015 StandoutNature
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
2010 Standout
Species‐specific detection of the antiviral small‐molecule compound CMA by STING
2013
Mitochondrion: an emerging platform critical for host antiviral signaling
2011
Atopic dermatitis
2015 Standout
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
The structural basis for the sensing and binding of cyclic di-GMP by STING
2012
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Cytosolic Sensing of Viruses
2013
Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP
2015
Recent insights into the complexity of Tank‐binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1
2013
STING and the innate immune response to nucleic acids in the cytosol
2012
Pattern Recognition Receptors and Inflammation
2010 Standout
Melioidosis
2012 Standout
Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response
2012
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
2014 Standout
Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein
2010 StandoutNobel
Severe Sepsis and Septic Shock
2013 Standout
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
2012
Autophagy: Renovation of Cells and Tissues
2011 Standout
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
2019 StandoutNobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
2014 StandoutNobel
Mitochondria: In Sickness and in Health
2012 Standout
Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
2013
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
2014
The JAK-STAT Pathway at Twenty
2012
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
2012
Intracellular DNA recognition
2010
Immune Sensing of DNA
2013
Methods in Mammalian Autophagy Research
2010 Standout
DNA recognition in immunity and disease
2013
TGFβ in Cancer
2008 Standout
Autophagy and Aging
2011 Standout
Autophagy and innate immunity: Triggering, targeting and tuning
2010
Mechanisms and Functions of Inflammasomes
2014 Standout
Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
2013
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA
2014
AKT/PKB Signaling: Navigating the Network
2017 Standout
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Early versus Late Parenteral Nutrition in Critically Ill Adults
2011 Standout
TRIM28 prevents autoinflammatory T cell development in vivo
2012 StandoutNobel
Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
2013
The functions and regulation of the PTEN tumour suppressor
2012 Standout
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
2014
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
2013
5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential
2012
The PI3K Pathway in Human Disease
2017 Standout
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
2013 Nature
Cytoplasmic DNA innate immune pathways
2011
IFI16 is an innate immune sensor for intracellular DNA
2010
Innate Immune Receptors
2016
Autophagy in immunity and inflammation
2011 StandoutNature
STING is a direct innate immune sensor of cyclic di-GMP
2011 Nature
Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
2013 StandoutNobel
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
PTEN
2014
TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides
2010
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Cytosolic DNA sensors regulating type I interferon induction
2011
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I
2015
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
2012
Nucleic Acid Recognition by the Innate Immune System
2011
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Regulation of innate immune responses by autophagy-related proteins
2010
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Hepatitis C Virus: Evading the Intracellular Innate Immunity
2020
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP
2011
Determinants and Functions of Mitochondrial Behavior
2014
Macrophage plasticity and polarization in tissue repair and remodelling
2012 Standout
Works of Lu Chen being referenced
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
2008
Ectopic T-bet Expression Licenses Dendritic Cells for IL-12-Independent Priming of Type 1 T Cells In Vitro
2009
Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
2011
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
2009
Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF-β1 Signaling Pathway
2012
Protein kinase C βII and TGFβRII in ω-3 fatty acid–mediated inhibition of colon carcinogenesis
2002
Intralesional Delivery of Dendritic Cells Engineered to Express T-bet Promotes Protective Type 1 Immunity and the Normalization of the Tumor Microenvironment
2010