Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 + T lymphocytes are prognostic factors of human ovarian cancer
2007 StandoutNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
TGF-β and cancer
1999
Inflammation and cancer
2002 StandoutNature
Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: Repression ofE6/E7-oncogene expression and induction of apoptosis
1996
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
The genetic regulation of apoptosis
1995
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β
2000
Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
2000 Standout
Strand-specific Mismatch Repair in Mammalian Cells
1997 StandoutNobel
Role of Transforming Growth Factor β in Human Disease
2000 Standout
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
1995
Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas
1997
Tumor Suppressing Pathways
1998
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Tumor surveillance via the ARF–p53 pathway
1998
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair
1997
Alteration of cell growth and morphology by overexpression of transforming growth factor β type II receptor in human lung adenocarcinoma cells
2001
The multistep nature of cancer
1993
When Checkpoints Fail
1997 StandoutNobel
A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF‐β signals
1998
The Hallmarks of Cancer
2000 Standout
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
The role of the E6-p53 interaction in the molecular pathogenesis of HPV
1999
Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes
1999
TGF-β singaling and cancer: structural and functional consequences of mutations in Smads
1998
p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1
1995
Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer
1994
Mutations of the transforming growth factor β type II receptor gene and microsatellite instability in gastric cancer
1996
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
2005
Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers
1997
KLF4, p21 and context-dependent opposing forces in cancer
2005
Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis
2000
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
1996
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
1996 StandoutNature
TGF-β receptor signaling
1997
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
1999
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Biochemical properties and biological effects of p53
1995
Taking dendritic cells into medicine
2007 StandoutNatureNobel
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Signaling of transforming growth factor‐β family members through Smad proteins
2000
A structural basis for mutational inactivation of the tumour suppressor Smad4
1997 Nature
Smad3 Mutant Mice Develop Metastatic Colorectal Cancer
1998
Spinning molecular immunology into successful immunotherapy
2002
Microsatellite Instability in Human Cancer: A Prognostic Marker for Chemotherapy?
1999
The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis
2001
Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes
1998
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
1999
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
1995 StandoutScienceNobel
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
1996
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers
1998
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion
1998
Cancer-related inflammation
2008 StandoutNature
TGF-β signaling by Smad proteins
2000
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
1994 Standout
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
1997 Nature
Cancer immunotherapy with mRNA‐transfected dendritic cells
2004
Crystal Structure of a Smad MH1 Domain Bound to DNA
1998
The Roles of E6-AP and MDM2 in p53 Regulation in Human Papillomavirus-Positive Cervical Cancer Cells
2000
Analyses of microsatellite instability and the transforming growth factor‐β receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features
1999
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
1997
TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
1998
TGF-β signaling by Smad proteins
2000
Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription
1999
Tumor suppressor activity of the TGF-β pathway in human cancers
1996
Characterization of Functional Domains within Smad4/DPC4
1997
Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer.
2000
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway
2000
Ubiquitination of p53 and p21 Is Differentially Affected by Ionizing and UV Radiation
1997
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
1998
TGF-β SIGNAL TRANSDUCTION
1998 Standout
G 1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation
1999
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
1994
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.
1997
Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis
2000
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells
1995 StandoutScienceNobel
Blocking transforming growth factor beta signaling in transgenic epidermis accelerates chemical carcinogenesis: a mechanism associated with increased angiogenesis.
1999
Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.
2001
Quality Control by DNA Repair
1999 StandoutScienceNobel
Induction of apoptosis in HeLa cells by trans-activation-deficient p53.
1995
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
1994
hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.
1994
Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.
1994
Specificity, diversity, and regulation in TGF-beta superfamily signaling.
1999
Cancer Cell Cycles
1996 StandoutScience
Increased Antigen Presentation Efficiency by Coupling Antigens to MHC Class I Trafficking Signals
2008
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Induction of cellular p53 activity by DNA-damaging agents and growth arrest.
1993
Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.
1996
Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program
2001
TGF-β–induced Phosphorylation of Smad3 Regulates Its Interaction with Coactivator p300/CREB-binding Protein
1998
Transforming growth factor-? responsiveness inDPC4/SMAD4-null cancer cells
1999
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells
1999
Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 Protein
1994 Science
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition
1997
Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator
1998
Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells.
1995
Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction
1999
Activation of p53 in cervical carcinoma cells by small molecules
2000
HUMAN T CELL RESPONSES AGAINST MELANOMA
2005
The S387Y mutations of the transforming growth factor-beta receptor type I gene is uncommon in metastases of breast cancer and other common types of adenocarcinoma.
1999
Interaction of Papillomavirus E6 Oncoproteins with a Putative Calcium-Binding Protein
1995 Science
TGF-β signalling through the Smad pathway
1997
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.
1995
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.
1999
Human DNA Repair Genes
2001 StandoutScienceNobel
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.
1994
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.
1994
Testing the Role of p53 in the Expression of Genetic Instability and Apoptosis in Ataxia-telangiectasia
1994
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Frequency of Smad gene mutations in human cancers.
1997
TbetaR-I(6A) is a candidate tumor susceptibility allele.
1999
Specificity, diversity, and regulation in TGF‐β superfamily signaling
1999
Transforming growth factor-beta receptor type I gene is frequently mutated in ovarian carcinomas.
2001
TGF-β and cancer
2005
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
1995 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
p53-Independent Role of MDM2 in TGF-β1 Resistance
1998 Science
Shared role of the pRB-related p130 and p107 proteins in limb development.
1996
Biochemistry and genetics of eukaryotic mismatch repair.
1996
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Another p53 Doppelgänger?
1998 StandoutScienceNobel
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
1996 StandoutScience
Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis
1998 Science
Works of Lora Hedrick being referenced
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
1993
The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas
1994
Cell adhesion molecules as tumour suppressors
1993
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
1994
Expression of HPV16 E6 or E7 increases integration of foreign DNA.
1996
DPC4 gene in various tumor types.
1996
A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.
1995
Microsatellite instability in endometrial carcinoma.
1994
p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells.
1995
Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens.
1995
Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.
1995