Standout Papers
- Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. (1980)
- Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro (1978)
- Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor. (1979)
- Characterization by electrophoresis of epidermal growth factor stimulated phosphorylation using A-431 membranes (1980)
Citation Impact
Citing Papers
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Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia
2000
Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and -2
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Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine
2000
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
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Chemical remodelling of cell surfaces in living animals
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3 ACAT Inhibitors: The Search for a Novel and Effective Treatment of Hypercholesterolemia and Atherosclerosis
2002
Protein Tyrosine Kinase Activity and Its Endogenous Substrates in Rat Brain: A Subcellular and Regional Survey
1988
ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia
2009
Effect of ACAT Inhibition on the Progression of Coronary Atherosclerosis
2006
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages
2001
Toxins which produce pain
1975
EGF and TGF-α stimulate retinal neuroepithelial cell proliferation in vitro
1991
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Atherosclerosis
2000 StandoutNature
Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast
1990 StandoutNatureNobel
Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs
1994 StandoutNatureNobel
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
2000
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
1989 StandoutNatureNobel
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Atherosclerosis
2001 Standout
Enzymatic activation of voltage-gated potassium channels
2006 Nature
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
1993
Synthetic tyrosine polymers as substrates and inhibitors of tyrosine-specific protein kinases.
1984
The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
1985 StandoutScienceNobel
Epidermal growth factor rapidly stimulates prolactin gene transcription
1982 Nature
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system
1982 Nature
Protein tyrosine phosphorylation in synaptic vesicles.
1988
Epidermal growth factor modulates extracellular Ca2+ requirement for multiplication of normal human skin fibroblasts
1979
Epidermal growth factor induces electrically silent Na+ influx in human fibroblasts.
1982
Enhancement of polyoma virus middle T antigen tyrosine phosphorylation by epidermal growth factor
1983 Nature
Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver.
1982 StandoutNobel
Genetic Control of Differentiation of the Caenorhabditis elegans Touch Receptor Neurons
1989 StandoutScienceNobel
A calcium-dependent 35-kilodalton substrate for epidermal growth factor receptor/kinase isolated from normal tissue.
1986 StandoutNobel
Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.
1983
Anti-pp60src antibodies are substrates for EGF-stimulated protein kinase
1981 Nature
The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.
1985 StandoutNobel
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
2003
Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus.
1981
Phosphotyrosyl-specific protein phosphatase activity of a bovine skeletal acid phosphatase isoenzyme. Comparison with the phosphotyrosyl protein phosphatase activity of skeletal alkaline phosphatase.
1985
Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia
1992 StandoutScienceNobel
ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA
1984 StandoutNatureNobel
Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor.
1989
Epidermal growth factor stimulates the phosphorylation of the calcium-dependent 35,000-dalton substrate in intact A-431 cells.
1985 StandoutNobel
Calcineurin-mediated dephosphorylation of the human placental membrane receptor for epidermal growth factor urogastrone
1985
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.
1983
Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase
1983 Nature
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
An acid phosphatase in the plasma membranes of human astrocytoma showing marked specificity toward phosphotyrosine protein.
1982
Regulation of Cell Growth and Transformation by Tyrosine-Specific Protein Kinases: The Search for Important Cellular Substrate Proteins
1983
Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine.
1984
Epidermal growth factor and epidermal growth factor receptor-dependent phosphorylation of a Mr = 34,000 protein substrate for pp60src.
1983
Epidermal growth factor stimulates tyrosine phosphorylation of specific proteins in permeabilized human fibroblasts.
1985
[42] Detection and quantification of phosphotyrosine in proteins
1983
Phosphorylation of human growth hormone by the epidermal growth factor-stimulated tyrosine kinase.
1983
A monoclonal antibody to the human epidermal growth factor receptor
1982
Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors.
1981
Epidermal growth factor, its receptor, and related proteins
1986
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
The kinetics of tyrosine phosphorylation by the purified epidermal growth factor receptor kinase of A-431 cells.
1983 StandoutNobel
Internalization of functional epidermal growth factor:receptor/kinase complexes in A-431 cells.
1985 StandoutNobel
Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.
1982
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
Increased phosphotyrosine content and inhibition of proliferation in EGF-treated A431 cells
1981 Nature
The human carcinoma cell line A431 possesses large numbers of functional β‐adrenergic receptors
1984
Serine kinase activity associated with moloney murine sarcoma virus-124-encoded p37mos
1985
Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase.
1985 StandoutNobel
Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.
1980 StandoutNobel
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts
1983 StandoutNatureNobel
Production and characterization of antibody blocking epidermal growth factor: Receptor interactions
1980
Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor.
1982
Altered epidermal growth factor (EGF)-stimulated protein kinase activity in variant A431 cells with altered growth responses to EGF
1982
Isolation of a calcium-dependent 35-kilodalton substrate for the epidermal growth factor receptor/kinase from A-431 cells.
1984 StandoutNobel
Epidermal growth factor inhibits growth of A431 human epidermoid carcinoma in serum-free cell culture.
1982
Epidermal Growth Factor-Urogastrone, a Polypeptide Acquiring Hormonal Status
1980
Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration.
1982
Vaccinia virus-infected cells release a novel polypeptide functionally related to transforming and epidermal growth factors.
1985
ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver
2004 StandoutNobel
Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
1982 Science
Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells.
1982 StandoutNobel
Insulin Receptor: Evidence That It Is a Protein Kinase
1983 Science
Controlled proteolysis of EGF receptors: Evidence for transmembrane distribution of the EGF binding and phosphate acceptor sites
1980
Rapid and specific enhancement of phosphorylation of two normal rat kidney cell membrane polypeptides of Mr = 170,000 and 150,000 by epidermal growth factor in vitro.
1981
Biosynthesis and metabolic degradation of receptors for epidermal growth factor
1986
Characterization of the major protein-tyrosine-phosphatases of human placenta.
1988 StandoutNobel
The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains
1985
Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase
1983 StandoutNatureNobel
Proteolytic cleavage of epidermal growth factor receptor. A Ca2+-dependent, sulfhydryl-sensitive proteolytic system in A431 cells.
1982
Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.
1982
A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta.
1984
Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase.
1983
Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor.
1981
A major phosphotyrosyl-protein phosphatase from bovine heart is associated with a low-molecular-weight acid phosphatase
1985
Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors.
1979 StandoutNobel
Evidence that viral transforming gene products and epidermal growth factor stimulate phosphorylation of the same cellular protein with similar specificity.
1981
Immunofluorescent localization of a 39,000-dalton substrate of tyrosine protein kinases to the cytoplasmic surface of the plasma membrane.
1983
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Epidermal growth factor: relationship between receptor down regulation in cultured NRK cells and epidermal growth factor enhancement of phosphorylation of a 170,000 molecular weight membrane protein in vitro
1981
Gold-Based Therapeutic Agents
1999
Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts.
1982
Characterization of the insulin receptor kinase purified from human placental membranes.
1983
p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.
1986
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.
1984
Solubilization of membrane receptor for epidermal growth factor
1979
Glycosylation of the epidermal growth factor receptor in A-431 cells. The contribution of carbohydrate to receptor function.
1984
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System
1992 StandoutScience
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.
1982
Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the M r 95,000 receptor subunit is its own kinase
1983
Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate
1982 StandoutNobel
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
1984 StandoutNature
Substrates of the epidermal growth factor receptor-kinase
1984
Partial purification and characterization of phosphotyrosyl-protein phosphatase from Ehrlich ascites tumor cells
1982
Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor.
1979 StandoutNobel
Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability.
1981
Regulatory Mechanisms in the Control of Protein Kinase
1982
Resistance to phosphatase of thiophosphorylated epidermal growth factor receptor in A431 membranes.
1982
Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMP.
1984
Subcellular Location of an Abundant Substrate (p36) for Tyrosine-Specific Protein Kinases
1983 StandoutNobel
Rapid rounding of human epidermoid carcinoma cells A-431 induced by epidermal growth factor
1981 StandoutNobel
Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor
1979
Calcium-mediated degradation of epidermal growth factor receptor in dislodged A431 cells and membrane preparations.
1983
Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
1985 StandoutNatureNobel
Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain
1987 Science
Partial deficiency of erythrocyte spectrin in hereditary spherocytosis
1985 StandoutNatureNobel
Epidermal Growth Factor
1979 StandoutNobel
Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein
1985
Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes
1986 StandoutNatureNobel
A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.
1982 StandoutNobel
Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells
1981 StandoutNobel
Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor
1982 Nature
Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.
1979
Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.
1981
Characterization of the interaction of 5'-p-fluorosulfonylbenzoyl adenosine with the epidermal growth factor receptor/protein kinase in A431 cell membranes.
1983 StandoutNobel
Phosphotyrosyl-protein phosphatase of TCRC-2 cells.
1982
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes.
1982
The .beta. subunit of the insulin receptor kinase is an insulin-activated protein
1983
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells
1981
Purified EGF receptor–kinase interacts specifically with antibodies to Rous sarcoma virus transforming protein
1981 StandoutNatureNobel
Immunoprecipitation of Insulin Receptors from Cultured Human Lymphocytes (IM-9 Cells) by Antibodies to pp60 src
1985 Science
Effect of epidermal growth factor on prostaglandin E1‐stimulated accumulation of cyclic AMP in fibroblastic cells
1979
Cassette of Eight Exons Shared by Genes for LDL Receptor and EGF Precursor
1985 StandoutScienceNobel
Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies.
1983
Acyl coenzyme A : cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
2001
Epidermal growth factor-stimulated phosphorylation of tyrosine residues on a 120 000 dalton protein in mouse liver plasma membrane subfractions
1981
[62] 5′-p-fluorosulfonylbenzoyl adenosine as a probe of ATP-binding sites in hormone receptor-associated kinases
1985
Selective dephosphorylation of proteins containing phosphotyrosine by alkaline phosphatases.
1981 StandoutNobel
Works of Lloyd E. King being referenced
Epidermal growth factor and its receptor in the developing human nervous system
1991
Localization of immunoreactive epidermal growth factor receptors in human nervous system.
1988
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
2000
Calcium effects on human erythrocyte membrane proteins
1977
The EGF receptor-kinase has multiple phosphorylation sites
1982
Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.
1980 StandoutNobel
Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro
1978 StandoutNatureNobel
Interaction of Brown Recluse Spider Venom on Cell Membranes: The Inciting Mechanism?
1984
Lichenoid dermatitis after consumption of gold-containing liquor
1997
Calcium facilitates endogenous proteolysis of the EGF receptor-kinase
1982
The visualization of human erythrocyte membrane proteins and glycoproteins in SDS polyacrylamide gels employing a single staining procedure
1976
Different forms of the epidermal growth factor receptor kinase have different autophosphorylation sites
1985
Characterization by electrophoresis of epidermal growth factor stimulated phosphorylation using A-431 membranes
1980 StandoutNobel
Protein phosphorylation in human placenta stimulation by epidermal growth factor
1980
Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.
1979 StandoutNobel
Pathogenesis of local tetanus in rats: Neural ascent of tetanus toxin
1974