Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways
2008
Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras -Induced Premature Senescence
2002
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
2003 Nature
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis
1999
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis
2000
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
1999 StandoutNature
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome)
1996
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
2009 Standout
Alternative isoform regulation in human tissue transcriptomes
2008 StandoutNature
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
2005 Standout
Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes
2007
A Core MYC Gene Expression Signature Is Prominent in Basal-Like Breast Cancer but Only Partially Overlaps the Core Serum Response
2009
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
2009 StandoutNature
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
1995
Genetic instabilities in human cancers
1998 StandoutNature
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
2004
Telomeres and telomerase in cancer
2009
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
APC mutations occur early during colorectal tumorigenesis
1992 StandoutNature
The Hallmarks of Cancer
2000 Standout
Lessons from Hereditary Colorectal Cancer
1996 Standout
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
2008
APC Genotype, Polyp Number, and Surgical Options in Familial Adenomatous Polyposis
1998
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation
2005
The Bloom's syndrome gene product is homologous to RecQ helicases
1995
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
The Molecular Basis of Turcot's Syndrome
1995
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
2008
The ABC of APC
2001
Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation
1996
Genetic regulators of large-scale transcriptional signatures in cancer
2006
Immunity, Inflammation, and Cancer
2010 Standout
Intrinsic tumour suppression
2004 Nature
The essence of senescence: Figure 1.
2010 Standout
High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts
2004
Identification and expansion of human colon-cancer-initiating cells
2006 StandoutNature
Linking Colorectal Cancer to Wnt Signaling
2000
Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds
1997
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
1994
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
2003
Mutations of theAPC adenomatous polyposis coli) gene
1993
Genomic instability occurs in colorectal carcinomas but not in adenomas
1993
Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
2011
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
2007
Hereditary Gastrointestinal Polyposis and Nonpolyposis Syndromes
1994
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
2014
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
2004 Standout
Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
1993
Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients
1993
Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer
1993
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
2014
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
1995 StandoutScienceNobel
The Hallmarks of Aging
2013 Standout
β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection
1999
Cancer-related inflammation
2008 StandoutNature
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
1993
Inherited Colorectal Polyposis and Cancer Risk of the APC I1307K Polymorphism
1999
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
The evolution of gene expression levels in mammalian organs
2011 StandoutNatureNobel
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Hypermutability and mismatch repair deficiency in RER+ tumor cells
1993 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis.
1996
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
2002
Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene.
1995
Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis
2010
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis
1997
Wnt signaling and cancer
2000 Standout
Inherited Susceptibility to Colorectal Cancer
2005
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.
2000
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
1995
Evidence against dominant negative mechanisms of intestinal polyp formation by Apc gene mutations.
1995
Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis.
1999
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
2001 StandoutNobel
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
1995 StandoutNobel
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
2010
The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history
1998
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
1999
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis
2010
Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.
2001
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli
1996
Dimer formation by an N-terminal coiled coil in the APC protein.
1993
Apoptosis and APC in colorectal tumorigenesis.
1996
Chemical Glycoproteomics
2016 StandoutNobel
Works of Lisa Spirio being referenced
Alleles of the APC gene: An attenuated form of familial polyposis
1993
A CA repeat 30 – 70 KB downstream from the adenomatous polyposis coli (APC) gene
1991
Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps
1998
Long-Range Physical Map and Deletion Characterization of the 1100-kbNotI Restriction Fragment Harboring theAPCGene
1996
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
2001
Mutational analysis of patients with adenomatous polyposis: identical inactivating mutations in unrelated individuals.
1993
A CA-repeat polymorphism close to the adenomatous polyposis coli (APC) gene offers improved diagnostic testing for familial APC.
1993
Response of colon cancer cell lines to the introduction of APC, a colon-specific tumor suppressor gene.
1995
Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas.
1999
Alternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC.
1995
Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.
1992
A CA repeat 30–70 Kb downstream from the adenomatous polyposis coli (APC) gene
1992