Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils
2001 Science
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
2008 StandoutScience
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
2010 StandoutScience
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2006 StandoutScience
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
2003
Roles of tau protein in health and disease
2017
The Ensembl Variant Effect Predictor
2016 Standout
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
2004
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Potent amyloidogenicity and pathogenicity of Aβ43
2011
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Cooexpression of FTDP-17 tau and GSK-3β in transgenic mice induce tau polymerization and neurodegeneration
2005
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy
2005
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease
2004
Locus Reference Genomic: reference sequences for the reporting of clinically relevant sequence variants
2013
Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease
2005
Aβ Oligomers – a decade of discovery
2007 Standout
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
2004
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
2003 Nature
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?
2002
Alzheimer's disease: Aβ, tau and synaptic dysfunction
2005
The Relationship between Lewy Body Disease, Parkinson's Disease, and Alzheimer's Disease
2003
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
2019 Standout
Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model
2010
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
2010
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
2005
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
ClinVar: public archive of relationships among sequence variation and human phenotype
2013 Standout
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
2011
Learning and Memory in Transgenic Mice Modeling Alzheimer's Disease
2001
Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau
2004
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Distinct Early Folding and Aggregation Properties of Alzheimer Amyloid-β Peptides Aβ40 and Aβ42
2006
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Transgenic models of Alzheimer’s disease: Learning from animals
2005
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)
2005
Tau phosphorylation: physiological and pathological consequences
2004
Protein folding and misfolding
2003 StandoutNature
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome
2004
Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease
2003
Deletion of Presenilin 1 Hydrophilic Loop Sequence Leads to Impaired γ-Secretase Activity and Exacerbated Amyloid Pathology
2006
Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles
2004
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles
2003 Standout
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
Lessons from a Failed γ-Secretase Alzheimer Trial
2014
Post-translational modifications of tau protein in Alzheimer’s disease
2004
Biomarker Modeling of Alzheimer’s Disease
2013
Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer Disease<subtitle>A Randomized Controlled Trial</subtitle>
2009
The Role of Apolipoprotein E in Alzheimer's Disease
2009
Selective α7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3β and decreases tau phosphorylation in vivo
2009
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
2005
Alzheimer's Disease
2010 Standout
Does my mouse have Alzheimer's disease?
2002
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
2017
Loss of autophagy in the central nervous system causes neurodegeneration in mice
2006 StandoutNature
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Resolving controversies on the path to Alzheimer's therapeutics
2011
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease
2006
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
2010
Revealing the world of RNA interference
2004 StandoutNatureNobel
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
2015
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
2004
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
2014
Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes
2014
Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium
2006
Genetics of Parkinsonʼs disease
2005
No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia
2006
Improving the Sequence Ontology terminology for genomic variant annotation
2015
ClinVar: public archive of interpretations of clinically relevant variants
2015 Standout
Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice
2010
Neurofibrillary Tangles Mediate the Association of Amyloid Load With Clinical Alzheimer Disease and Level of Cognitive Function
2004
Antibodies against β‐amyloid reduce aβ oligomers, glycogen synthase kinase‐3β activation and τ phosphorylation in vivo and in vitro
2005
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology
2002
Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice
2007
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
2007
Aβ40 Inhibits Amyloid DepositionIn Vivo
2007
Genetically engineered mouse models of neurodegenerative diseases
2002
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
2003
γ-Secretase and its modulators: Twenty years and beyond
2019
Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
2011
Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers
2006
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
2011
A Century of Alzheimer's Disease
2006 StandoutScience
Mutations causing neurodegenerative tauopathies
2004
Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies
2008
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Ion-dependent protein–surface interactions from intrinsic solvent response
2021 StandoutNobel
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease
2002
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Alzheimer’s Disease: The Challenge of the Second Century
2011
Tau-Mediated Cytotoxicity in a Pseudohyperphosphorylation Model of Alzheimer's Disease
2002
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
2013
Toxic Proteins in Neurodegenerative Disease
2002 Science
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
2005 StandoutScience
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
2012
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 StandoutScience
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
2002
Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
2015 Science
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
2016
Works of Lisa Skipper being referenced
Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease
2005
Linkage Disequilibrium and Association of MAPT H1 in Parkinson Disease
2004
Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice
2005
α‐Synuclein promoter confers susceptibility to Parkinson's disease
2004
dbVar and DGVa: public archives for genomic structural variation
2012
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
2001 Science