Citation Impact
Citing Papers
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells
2003 StandoutScience
Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice
2008 StandoutNobel
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
Effective expansion of alloantigen-specific Foxp3 + CD25 + CD4 + regulatory T cells by dendritic cells during the mixed leukocyte reaction
2006 StandoutNobel
Induction of CD4+ T Cell Alloantigen-Specific Hyporesponsiveness by IL-10 and TGF-β
1999
Adenoviral Transfer of the Viral IL-10 Gene Periarticularly to Mouse Paws Suppresses Development of Collagen-Induced Arthritis in Both Injected and Uninjected Paws
1999
Interleukin 10 (IL-10): an immunosuppressive factor and independent predictor in patients with metastatic renal cell carcinoma
1999
Functional diversity of helper T lymphocytes
1996 StandoutNature
Interleukin-10 Stimulation of Phosphatidylinositol 3-Kinase and p70 S6 Kinase Is Required for the Proliferative but Not the Antiinflammatory Effects of the Cytokine
1996
Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus
2000
IL-10 AS A THERAPEUTIC STRATEGY IN THE TREATMENT OF RHEUMATOID ARTHRITIS
1998
RETROVIRAL DELIVERY OF VIRAL INTERLEUKIN-10 INTO MYELOID DENDRITIC CELLS MARKEDLY INHIBITS THEIR ALLOSTIMULATORY ACTIVITY AND PROMOTES THE INDUCTION OF T-CELL HYPORESPONSIVENESS1,2
1998
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
2009 StandoutNature
The role of B7 co‐stimulation in activation and differentiation ofCD4+and CD8+T cells
1998
IL-10 Inhibits the Primary Allogeneic T Cell Response to Human Peripheral Blood Dendritic Cells
1995
Interleukin‐10: Potential Benefits and Possible Risks in Clinical Infectious Diseases
1998
Suppressive Effects of Interleukin‐10 on Human Mononuclear Phagocyte Function againstCandida albicansandStaphylococcus aureus
1998
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
2000 StandoutNature
IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
1998
IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response
1999
Cells’ Perception of Position in a Concentration Gradient
1998 StandoutNobel
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature
Regulatory T Cells
2000 StandoutNobel
Effect of interleukin‐10 on dendritic cell maturation and function
1997
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells
1994
Activation of naive, memory and effector T cells
1994
Paralysis of B7 co-stimulation through the effect of viral IL-10 on T cells as a mechanism of local tolerance induction
1998
SYSTEMIC ADMINISTRATION OF ANTI-INTERLEUKIN-10 ANTIBODY PROLONGS ORGAN ALLOGRAFT SURVIVAL IN NORMAL AND PRESENSITIZED RECIPIENTS1,2
1998
Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.
1993
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
2007 StandoutNature
Gene transfer of virally encoded chemokine antagonists vMIP-II and MC148 prolongs cardiac allograft survival and inhibits donor-specific immunity
2000
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Interleukin‐10 inhibition of the progression of established collagen‐induced arthritis
1996
Modifications of CD8+ T Cell Function during In Vivo Memory or Tolerance Induction
1998
IL-10 immunosuppression in transplantation
1995
In vivo effects of locally secreted IL-10 on the murine antitumor immune response
1996
Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation
1999
Tumor-Associated Macrophages: From Mechanisms to Therapy
2014 Standout
Mechanisms of allergen-specific immunotherapy
2011
T‐cell cytokines may control the balance of functionally distinct macrophage populations
1997
SYSTEMIC ADMINISTRATION OF CELLULAR INTERLEUKIN-10 CAN EXACERBATE CARDIAC ALLOGRAFT REJECTION IN MICE1,2
1996
IL-10: Evolving concepts☆☆☆★★★
1998
Interleukin-10 (IL-10) Augments Allograft Arterial Disease
1999
Interleukin‐10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin‐4 and granulocyte/ macrophage‐colony‐stimulating factor
1997
The development of allergic inflammation
2008 StandoutNature
Enhancement of endotoxin‐induced interleukin‐10 production by SR 31747A, a sigma ligand
1995
Adenovirus-Mediated Gene Transfer of Viral Interleukin-10 Inhibits the Immune Response to Both Alloantigen and Adenoviral Antigen
1997
T cell stimulation upon long-term secretion of viral IL-10
1999
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
1997 StandoutNature
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Specific and non-specific immunity to Candida albicans a lesson from genetically modified animals
1998
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo
2003
Atherosclerosis — An Inflammatory Disease
1999 Standout
Human CD4+ T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Th1 Immune Responses
2000
A PILOT TRIAL OF RECOMBINANT HUMAN INTERLEUKIN-10 IN KIDNEY TRANSPLANT RECIPIENTS RECEIVING OKT3 INDUCTION THERAPY1,2
1997
Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses
1994
Regulatory T cells in the control of immune pathology
2001
A microbial symbiosis factor prevents intestinal inflammatory disease
2008 StandoutNature
Antigen presentation to naive CD4 T cells in the lymph node
2003
Role of interleukin 10 in specific immunotherapy.
1998 Standout
Interleukin‐12 and B7.1 co‐stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors
1996
Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes
1994
Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner
2011
Regulatory T cells and inflammatory bowel disease
1999
Systemic Release of Interleukin–10 During Orthotopic Liver Transplantation
1994
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
2003
DIFFERENTIAL EFFECTS OF EXOGENOUS INTERLEUKIN-10 ON CARDIAC ALLOGRAFT SURVIVAL1,2
1999
AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER
1997
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
1998 StandoutNature
Selective enhancement of endothelial cell VCAM‐1 expression by interleukin‐10 in the presence of activated leucocytes
1997
GM-CSF and B7-1 (CD80) co-stimulatory signals co-operate in the induction of effective anti-tumor immunity in syngeneic mice
1997
Implantation and the placenta: key pieces of the development puzzle
1994 StandoutScience
Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
2002
Establishment and Persistence of Virus‐Specific CD4+ and CD8+ T Cell Memory
1996 StandoutNobel
Characterization of Recombinant Extracellular Domain of Human Interleukin-10 Receptor
1995
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
2006 StandoutNature
Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation
1992
Antifungal type 1 responses are upregulated in IL-10-deficient mice
1999
Involvement of CD40 Ligand-CD40 and CTLA4-B7 Pathways in Murine Acute Graft-Versus-Host Disease Induced by Allogeneic T Cells Lacking CD28
1998
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis
1998
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+T cell responses
1999 StandoutNobel
T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing Both T Cell and APC Function
1999
The Central Role of CD4+ T Cells in the Antitumor Immune Response
1998
Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasis
1997
Interleukin -10and Related Cytokines and Receptors
2004
IL-10 augments CD23 expression on U937 cells and down-regulates IL-4-driven CD23 expression on cultured human blood monocytes: effects of IL-10 and other cytokines on cell phenotype and phagocytosis.
1995
Modulation of host immune responses by nematode cystatins
2003
Coupling of Peripheral Tolerance to Endogenous Interleukin 10 Promotes Effective Modulation of Myelin-Activated T Cells and Ameliorates Experimental Allergic Encephalomyelitis
2000
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.
1995
CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
1998 StandoutNobel
Lack of interleukin 10 regulation of antigen presentation‐associated molecules expressed on colonic epithelial cells
1999
Interleukin 10 production by human melanoma.
1996
Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.
1996
Phenotypic Analysis of Antigen-Specific T Lymphocytes
1996 StandoutScience
Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells
1997
Identification of an IL-10-Producing HLA-DR-Negative Monocyte Subset in the Malignant Ascites of Patients with Ovarian Carcinoma That Inhibits Cytokine Protein Expression and Proliferation of Autologous T Cells
1999
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
1995 StandoutNobel
Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.
1996
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
2000 StandoutNobel
CD28/B7 SYSTEM OF T CELL COSTIMULATION
1996 Standout
Regulatory function ofin vivoanergized CD4+T cells
2001
Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo
1998
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation.
1995
Interleukin‐10‐induced CD8 cell proliferation
1999
Treatment with anti-interleukin-10 monoclonal antibody enhances early resistance to but impairs complete clearance of Listeria monocytogenes infection in mice
1994
Immunoregulation in experimental murine Trypanosoma congolense infection: anti‐IL‐10 antibodies reverse trypanosome‐mediated suppression of lymphocyte proliferation in vitro and moderately prolong the lifespan of genetically susceptible BALB/c mice
1998
Interleukin 10 (IL-10) regulation of tumour necrosis factor alpha (TNF-alpha) from human alveolar macrophages and peripheral blood monocytes.
1996
Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii
1997
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
Differential Regulation of Immune Responses by Highly and Weakly VirulentCryptococcus neoformansIsolates
1999
Altered Immune Responses in Interleukin 10 Transgenic Mice
1997
Induction of hapten-specific tolerance by interleukin 10 in vivo.
1994
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
On the Edge of Autoimmunity
2005
IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.
1996
TRACP Influences Th1 Pathways by Affecting Dendritic Cell Function
2006 StandoutNobel
Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.
1994
Human interleukin-10 can directly inhibit T-cell growth
1993
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Constitutive IL-10 Production Accounts for the High NK Sensitivity, Low MHC Class I Expression, and Poor Transporter Associated with Antigen Processing (TAP)-1/2 Function in the Prototype NK Target YAC-1
1998
CD40‐deficient dendritic cells producing interleukin‐10, but not interleukin‐12, induce T‐cell hyporesponsiveness in vitro and prevent acute allograft rejection
1999
The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
2004
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
1994
Viral interleukin 10 is critical for the induction of B cell growth transformation by Epstein-Barr virus.
1993
Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.
1994
Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis
2002
Anergic T Cells as Suppressor Cells in Vitro
1994 Science
Lack of Evidence for the Dichotomy of T H 1 and T H 2 Predominance in HIV-Infected Individuals
1994 Science
Interleukin-10 Upregulates Tumor Necrosis Factor Receptor Type-II (p75) Gene Expression in Endotoxin-Stimulated Human Monocytes
1997
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
1993
Resistance of Rheumatoid Synovial Dendritic Cells to the Immunosuppressive Effects of IL-10
1999
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+T cells
2000 StandoutNobel
Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells.
1998
Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta.
1999
IL-10 enhances IL-2-induced proliferation and cytotoxicity by human intestinal lymphocytes
2000
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines
2002
Tumor Necrosis Factor Alpha-Mediated Toxic Shock inTrypanosoma cruzi-Infected Interleukin 10-Deficient Mice
2000
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists
1995 Science
Nonproliferating Bystander CD4+ T Cells Lacking Activation Markers Support HIV Replication During Immune Activation
2001 StandoutNobel
The Role of B7‐1/B7‐2:CD28/CLTA‐4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down‐Regulation of the Immune Response
1996
Inhibitory and Stimulatory Effects of IL-10 on Human CD8+ T Cells
1998
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Works of Linna Ding being referenced
Activation of CD4+ T cells by delivery of the B7 costimulatory signal on bystander antigen‐presenting cells (trans‐costimulation)
1994
IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function
1992
B7/CD28-dependent and -independent induction of CD40 ligand expression.
1995
IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.
1993