Standout Papers
Citation Impact
Citing Papers
T cell metabolism drives immunity
2015
Adult-onset pulmonary fibrosis caused by mutations in telomerase
2007
Accelerated telomere shortening in response to life stress
2004 StandoutNobel
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
Short telomeres are a risk factor for idiopathic pulmonary fibrosis
2008
Hallmarks of Cancer: The Next Generation
2011 Standout
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
2012
Linking functional decline of telomeres, mitochondria and stem cells during ageing
2010 Nature
The DNA-damage response in human biology and disease
2009 StandoutNature
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
2006
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
2016
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA
2005 StandoutNobel
The natural history of telomeres: tools for aging animals and exploring the aging process
2003
DNA and its associated processes as targets for cancer therapy
2002
Short Telomeres Initiate Telomere Recombination in Primary and Tumor Cells
2009 StandoutNobel
How Telomerase Reaches Its End: Mechanism of Telomerase Regulation by the Telomeric Complex
2008
Alternative isoform regulation in human tissue transcriptomes
2008 StandoutNature
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
The epigenetic regulation of mammalian telomeres
2007
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
2007 StandoutNobel
Crystal structure of parallel quadruplexes from human telomeric DNA
2002 StandoutNature
Cellular senescence: when bad things happen to good cells
2007 Standout
Regulation of Telomere Elongation by the Cyclin-Dependent Kinase CDK1
2006 StandoutNobel
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
2005
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice
2007
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
2002
Cellular senescence and organismal aging
2008
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
2009 StandoutNobel
Telomeres and telomerase in cancer
2009
Genetic Animal Models of Parkinson's Disease
2010
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
2011 Standout
Catalytically active human telomerase mutants with allele-specific biological properties
2003
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells
2009
Shortened telomeres join to DNA breaks interfering with their correct repair
2003
Axis of ageing: telomeres, p53 and mitochondria
2012
Telomeres in T and B cells
2002
Human Cancer Cells Harbor T-Stumps, a Distinct Class of Extremely Short Telomeres
2007 StandoutNobel
Telomere dysfunction and the initiation of genome instability
2003 StandoutNobel
Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence
2007 StandoutNobel
The telomere syndromes
2012 Nobel
RNA-binding proteins in neurodegeneration: Seq and you shall receive
2015
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
2006 StandoutNobel
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 Standout
How stem cells age and why this makes us grow old
2007
Telomeres and cancer: a tale with many endings
2003
No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells
2008
Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation
2005 StandoutNobel
Telomerase-independent Regulation of ATR by Human Telomerase RNA
2006
Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression
2003
Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging
2009 StandoutNobel
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States
2004
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
2009
Telomerase and Tel1p Preferentially Associate with Short Telomeres in S. cerevisiae
2007
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
2007
HITS-CLIP yields genome-wide insights into brain alternative RNA processing
2008 Nature
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans
2006
Chromosomal instability in ulcerative colitis is related to telomere shortening
2002
Ageing and telomeres: a study into organ- and gender-specific telomere shortening
2003
A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis
2008
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
HITS‐CLIP: panoramic views of protein–RNA regulation in living cells
2010
A G-Quadruplex-Interactive Potent Small-Molecule Inhibitor of Telomerase Exhibiting in Vitro and in Vivo Antitumor Activity
2002
The role of senescent cells in ageing
2014 StandoutNature
The telomerase activator TA‐65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
2011
mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription
2012
The Hallmarks of Aging
2013 Standout
Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency
2006 Nobel
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis
2002 StandoutNobel
The role of telomeres and telomerase in stem cell aging
2010
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
Tel1p Preferentially Associates with Short Telomeres to Stimulate Their Elongation
2007
Extensive allelic variation and ultrashort telomeres in senescent human cells
2003
ATM-like kinases and regulation of telomerase: lessons from yeast and mammals
2008
Frailty in elderly people
2013 Standout
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Cell senescence and cancer
2001
Haploinsufficiency of mTR results in defects in telomere elongation
2002 StandoutNobel
Telomerase core components protect Candida telomeres from aberrant overhang accumulation
2007 StandoutNobel
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres
2005
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres
2006 StandoutNobel
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
2018 Standout
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Whole chromosome loss is promoted by telomere dysfunction in primary cells
2010
Syndromes of Telomere Shortening
2009
The effect of TERC haploinsufficiency on the inheritance of telomere length
2005
Kinase-Independent Functions of TEL1 in Telomere Maintenance
2009 StandoutNobel
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
2003 StandoutNobel
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert
2002
MEC3,MEC1,andDDC2Are Essential Components of a Telomere Checkpoint Pathway Required for Cell Cycle Arrest during Senescence inSaccharomyces cerevisiae
2002
Short Telomeres Induce a DNA Damage Response inSaccharomyces cerevisiae
2003 StandoutNobel
Haploinsufficiency of t e lomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita
2005 StandoutNobel
How Shelterin Protects Mammalian Telomeres
2008 Standout
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation
2015 Nature
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
2003
End Resection Initiates Genomic Instability in the Absence of Telomerase
2003 StandoutNobel
Works of Ling-Yang Hao being referenced
Programmed Death-1 Controls T Cell Survival by Regulating Oxidative Metabolism
2015
Anaplerotic Metabolism of Alloreactive T Cells Provides a Metabolic Approach To Treat Graft-Versus-Host Disease
2014
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
Inflammasomes in inflammatory bowel disease pathogenesis
2013
Phosphorylation of H2AX at Short Telomeres in T Cells and Fibroblasts
2004 StandoutNobel
Genomic instability in�both wild-type and telomerase null MEFs
2004
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways
2008