Citation Impact
Citing Papers
Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer–Associated Fibroblasts
2010
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
2009
A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer
2012
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
2013
Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding
2011
Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
2011
Small-molecule modulators of the Sonic Hedgehog signaling pathway
2009
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
2017 Standout
Two Distinct Sites in Sonic Hedgehog Combine for Heparan Sulfate Interactions and Cell Signaling Functions
2011
Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis
2009
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
2012 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Carcinoma‐associated fibroblasts: Non‐neoplastic tumour‐promoting mesenchymal cells
2013
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Pancreatic cancer
2004 Standout
Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
2009 Standout
Ageing and vision: structure, stability and function of lens crystallins
2003
In vitro and in vivo characterization of a novel hedgehog signaling antagonist in human glioblastoma cell lines
2011
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
Cancer to bone: a fatal attraction
2011 Standout
Genetically engineered mouse models of pancreatic adenocarcinoma
2013
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
2012 Standout
Peptide Epitope Identification by Affinity Selection on Bacteriophage MS2 Virus-Like Particles
2011
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
TGFβ signalling in context
2012 Standout
Marine natural products
1990 Standout
WNT signalling pathways as therapeutic targets in cancer
2012 Standout
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
2015 StandoutNature
The Hedgehog's tale: developing strategies for targeting cancer
2011
Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment
2014
Modulation of oxidative stress as an anticancer strategy
2013 Standout
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
2015 Standout
Modulators of the hedgehog signaling pathway
2010
The biology and function of fibroblasts in cancer
2016 Standout
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
2015
Canonical and Noncanonical Hedgehog/GLI Signaling in Hematological Malignancies
2012
Small‐Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
2010
Cancer stem cells revisited
2017 Standout
Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
2010
Cancer-associated fibroblasts and tumor growth – bystanders turning into key players
2009
The Role of Stromal Myofibroblast and Extracellular Matrix in Tumor Angiogenesis
2011
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Hallmarks of cancer: Interactions with the tumor stroma
2010
Interactions and chaperone function of αA‐crystallin with T5P γC‐crystallin mutant
2004
Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity
2012
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
2009
Pancreatic Adenocarcinoma
2014 Standout
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
The P23T Cataract Mutation Causes Loss of Solubility of Folded γD-Crystallin
2004
Nanomaterials for cancer immunotherapy
2017
MMTV-Wnt1 and -ΔN89β-Catenin Induce Canonical Signaling in Distinct Progenitors and Differentially Activate Hedgehog Signaling within Mammary Tumors
2009
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
2012
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
2009 Standout
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
Remodelling the extracellular matrix in development and disease
2014 Standout
Human Correlates of Provocative Questions in Pancreatic Pathology
2012
Mesenchymal Cells in Colon Cancer
2017
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
2009
Fibroblasts as architects of cancer pathogenesis
2012
Cooperative Hedgehog-EGFR signaling
2011
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
2023 Standout
Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
2011
Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
2010
The cancer stem cell: premises, promises and challenges
2011 Standout
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site
2010
Crystallin γB-I4F Mutant Protein Binds to α-Crystallin and Affects Lens Transparency
2005 StandoutNobel
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
2010
New developments in the discovery of small molecule Hedgehog pathway antagonists
2010
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
2010 Nature
Basic and Therapeutic Aspects of Angiogenesis
2011 Standout
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
2009
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
2011 Nature
Inflammation and cancer stem cells
2013
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Co-evolution of tumor cells and their microenvironment
2008
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
VEGF in Signaling and Disease: Beyond Discovery and Development
2019 Standout
Hedgehog Signaling in Development and Cancer
2008 Standout
Cancer stem cells: potential target for bioactive food components
2012
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug-Resistant Mutant of Smoothened
2011
Pancreatic cancer
2011 Standout
Tumor–stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition
2012
Pancreatic Cancer Stem Cells
2008
Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation
2010
Metastasis-Initiating Cells and Ecosystems
2021
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Synthesis and Structure Revision of Nakiterpiosin
2008
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
2009
Gli Proteins in Development and Disease
2011
Human colon cancer epithelial cells harbour active HEDGEHOG‐GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
2009
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
2012
Targeting Hedgehog — a Cancer Stem Cell Pathway
2010
Cataracts
2017 Standout
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Fibroblast heterogeneity in the cancer wound
2014
Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
2012
Genetics of Congenital Cataract
2016
Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents
2009
Paracrine Hedgehog Signaling in Cancer
2009
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
2014
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
2010
Works of Ling Fu being referenced
A Phase II, Randomized, Placebo-Controlled Study of Vismodegib as Maintenance Therapy in Patients with Ovarian Cancer in Second or Third Complete Remission
2012
Conformational change and destabilization of cataract γC‐crystallin T5P mutant
2002
The 2β2–2β3 loop of anthrax protective antigen contains a dominant neutralizing epitope
2006
Unfolding of human lens recombinant βB2- and γC-crystallins
2002
A paracrine requirement for hedgehog signalling in cancer
2008 Nature