Standout Papers
Citation Impact
Citing Papers
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
2006
Shh Pathway Activity Is Down-Regulated in Cultured Medulloblastoma Cells: Implications for Preclinical Studies
2006
Small-molecule modulators of the Sonic Hedgehog signaling pathway
2009
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo
2006 StandoutNobel
Basal cell carcinomas: attack of the hedgehog
2008 Standout
Deregulation of Dorsoventral Patterning by FGF Confers Trilineage Differentiation Capacity on CNS Stem Cells In Vitro
2003
Inhibition ofSmoothenedSignaling Prevents Ultraviolet B-Induced Basal Cell Carcinomas through Regulation of Fas Expression and Apoptosis
2004
Sonic hedgehog signaling in basal cell carcinomas
2004
Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer
2009
Hedgehog signalling in cancer formation and maintenance
2003 Standout
Hedgehog: functions and mechanisms
2008 Standout
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
2009 Standout
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
2006 Standout
Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
2014 Standout
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle
2004
Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors
2002
KIF1Bβ Functions as a Haploinsufficient Tumor Suppressor Gene Mapped to Chromosome 1p36.2 by Inducing Apoptotic Cell Death
2008
Cancer Metastasis: Building a Framework
2006 Standout
TGFβ signalling in context
2012 Standout
Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcoma
2004
Developmental biology informs cancer
2003
The Hedgehog's tale: developing strategies for targeting cancer
2011
Neuroblastoma: biological insights into a clinical enigma
2003 Standout
COVID-19: A promising cure for the global panic
2020 Standout
Canonical and Noncanonical Hedgehog/GLI Signaling in Hematological Malignancies
2012
Gene expression profiling and identification of novel prognostic marker genes in neuroblastoma
2004
Small‐Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
2010
Targeting the Hedgehog pathway in cancer
2006 Standout
A small molecule that binds Hedgehog and blocks its signaling in human cells
2009
Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2
2001
Cancer genes and the pathways they control
2004 Standout
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
2007
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
2002
In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice
2004
The cell biology of neurogenesis
2005 Standout
Tissue repair and stem cell renewal in carcinogenesis
2004 Nature
An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
2008 Standout
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
2009 Standout
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
Molecular requirements for epithelial–mesenchymal transition during tumor progression
2005 Standout
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
2013 Standout
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
2009
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
2011 Standout
TGFβ in Cancer
2008 Standout
Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
2010
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
2009
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor
2011
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
Drugging Hedgehog: signaling the pathway to translation
2013
Neuroblastoma
2007 Standout
Stem Cells and Cancer
2004 Standout
New cancer targets emerging from studies of the Von Hippel‐Lindau tumor suppressor protein
2010 StandoutNobel
Hedgehog–Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer
2003
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
2014 Standout
Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure
2008
Hepatocellular carcinoma pathogenesis: from genes to environment
2006 Standout
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice
2004
Hedgehog Signaling in Development and Cancer
2008 Standout
The primary cilium: a signalling centre during vertebrate development
2010 Standout
Constitutive Hedgehog Signaling in Chondrosarcoma Up-Regulates Tumor Cell Proliferation
2006
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
2002 Standout
Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug-Resistant Mutant of Smoothened
2011
The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
2008 StandoutNobel
Targeting Medulloblastoma: Small-Molecule Inhibitors of the Sonic Hedgehog Pathway as Potential Cancer Therapeutics
2005
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet
2020
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
2008
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
2009
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
2007 StandoutScience
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
The extracellular matrix: A dynamic niche in cancer progression
2012 Standout
Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach
2020 Standout
THE HEDGEHOG PATHWAY AND NEUROLOGICAL DISORDERS
2006
Small molecule modulation of Smoothened activity
2002 Standout
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
2006
Identification of Pancreatic Cancer Stem Cells
2007 Standout
Targeting Hedgehog — a Cancer Stem Cell Pathway
2010
Organokatalytische Synthese von enantiomerenreinen 2H‐ und 3H‐Pyrrolen: Inhibitoren des Hedgehog‐Signalwegs
2016 StandoutNobel
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug
2014 Standout
Hedgehog Signaling Promotes Prostate Xenograft Tumor Growth
2004
Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents
2009
The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report
2008 Standout
The Hedgehog Signaling Pathway in Cancer
2006
Applied Hydroformylation
2012 Standout
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
2010
Wound healing - A literature review
2016 Standout
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of Ling Chai being referenced
Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
2003
Homozygous deletion in a neuroblastoma cell line defined by a high‐density STS map spanning human chromosome band 1p36
2001
Overview of pharmacological activities ofAndrographis paniculataand its major compound andrographolide
2018 Standout