Citation Impact
Citing Papers
NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching
2004
The Spatial Organization of the Human Genome
2013
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis
2015
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Origins of Specificity in Protein-DNA Recognition
2010
Probing Allostery Through DNA
2013 Science
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
2006 StandoutNobel
Comprehensive Identification of Human bZIP Interactions with Coiled-Coil Arrays
2003 Science
Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans
2008 Science
How do dynamic cellular signals travel long distances?
2011
An EGFR/Ebi/Sno Pathway Promotes Delta Expression by Inactivating Su(H)/SMRTER Repression during Inductive Notch Signaling
2002
Repression by Suppressor of Hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo
2000
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway
2002
Genetic and Epigenetic Determinants of Neurogenesis and Myogenesis
2012
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Classification of human genomic regions based on experimentally determined binding sites of more than 100 transcription-related factors
2012
Functional Diversity among Notch1, Notch2, and Notch3 Receptors
2002
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Notch pathway: Making sense of Suppressor of Hairless
2001
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons
2017 StandoutNobel
Eukaryotic regulatory RNAs: an answer to the ‘genome complexity’ conundrum
2007
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
2006 StandoutNature
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
2006 Nature
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
2002
Single-cell chromatin accessibility reveals principles of regulatory variation
2015 Nature
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Photochemical regulation of the activity of an endonuclease BamHI using an azobenzene moiety incorporated site-selectively into the dimer interface
2004
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
NFAT Signaling
2002
Store-Operated CRAC Channels Regulate Gene Expression and Proliferation in Neural Progenitor Cells
2014
Mapping Neural Circuits with Activity-Dependent Nuclear Import of a Transcription Factor
2012
Calcium signalling in lymphocyte activation and disease
2007
Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors
2009
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
2003
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
Solution structure of the single-strand break repair protein XRCC1 N-terminal domain.
1999
Normalization of a chromosomal contact map
2012
Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases
1999
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
2000
The Human Transcription Factors
2018 Standout
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
T-cell anergy
2004
Regulation of Marginal Zone B Cell Development by MINT, a Suppressor of Notch/RBP-J Signaling Pathway
2003 StandoutNobel
Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes
2006
NFAT signaling in vertebrate development
2001
The Transcription Factor NFAT3 Mediates Neuronal Survival
2004
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
2006 StandoutNature
Notch signalling: a simple pathway becomes complex
2006 Standout
Ca2+/calcineurin signalling in cells of the immune system
2003
SOCE in neurons: Signaling or just refilling?
2015
Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5
2000 StandoutNobel
Analysis of variation at transcription factor binding sites in Drosophila and humans
2012
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Multiparameter functional diversity of human C2H2 zinc finger proteins
2016
NFAT activation by membrane potential follows a calcium pathway distinct from other activity-related transcription factors in skeletal muscle cells
2008
Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA
2006
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
2004
Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein
2010
Deciphering the role of Notch signaling in lymphopoiesis
2002
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
A Notch-Independent Activity of Suppressor of Hairless Is Required for Normal Mechanoreceptor Physiology
2000
Geometric analysis and comparison of protein-DNA interfaces: why is there no simple code for recognition? 1 1Edited by R. Ebright
2000
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis
2000
Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid
2008
Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models
2008
Notch Signaling: From the Outside In
2000
Transcription Factor Effector Domains
2011
Absence of a simple code: how transcription factors read the genome
2014
A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis
2004
Life in the balance: how BH3-only proteins induce apoptosis
2005
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
1998 Standout
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
2014 Standout
Long noncoding RNAs: functional surprises from the RNA world
2009 Standout
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
2012
The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
2001
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
2006
Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
2002
The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector
2004
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Iterative correction of Hi-C data reveals hallmarks of chromosome organization
2012
Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra)
2010
Single-cell Hi-C reveals cell-to-cell variability in chromosome structure
2013 Nature
Epstein–Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter
2000
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Signaling in Myocardial Hypertrophy
1999
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Quality Control by DNA Repair
1999 StandoutScienceNobel
Calcineurin Mediates the Gonadotropin-Releasing Hormone Effect on Expression of Both Subunits of the Follicle-Stimulating Hormone through Distinct Mechanisms
2011
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
1985 StandoutNobel
Calcium‐dependent deceleration of the cell cycle in muscle cells by simulated microgravity
2013
NFAT isoforms control activity-dependent muscle fiber type specification
2009
A model Notch response element detects Suppressor of Hairless–dependent molecular switch
2001
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Inhibition Mechanism of the Acetylcholine Receptor by α-Neurotoxins as Revealed by Normal-Mode Dynamics
2008 StandoutNobel
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
Structure of the human NF-kappa B p52 homodimer-DNA complex at 2.1Aresolution
1997
Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex
2001
A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT
2005 Science
The cardenolide UNBS1450 is able to deactivate nuclear factor κB–mediated cytoprotective effects in human non–small cell lung cancer cells
2006
Principles of Allosteric Interactions in Cell Signaling
2014
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin
2016
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function
2000
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
1997
Regulation of Notch Signaling Activity
2004
Works of Lin Chen being referenced
Structure of NFAT Bound to DNA as a Monomer
2003
DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation
2012
An asymmetric NFAT1 dimer on a pseudo-palindromic κB-like DNA site
2003
Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4
2004
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
1998 Nature
Transcriptional regulation by calcium, calcineurin, and NFAT
2003 Standout
Genome architectures revealed by tethered chromosome conformation capture and population-based modeling
2011
Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion
2013
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc
1997 Nature
Crystal Structure of NFAT Bound to the HIV-1 LTR Tandem κB Enhancer Element
2008
Structure of NFAT1 bound as a dimer to the HIV-1 LTR κB element
2003
Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 Å resolution
2007
DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity
2009 Science
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
1999
Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling
2013