Citation Impact
Citing Papers
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
2008
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
2009 Nature
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
2005 StandoutNobel
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
2008 Standout
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
2005 StandoutNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
2014
Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia
2007
A view on drug resistance in cancer
2019 StandoutNature
Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs
2002
BH3-only proteins: Orchestrators of apoptosis
2010
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
2013
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
2008
Antioxidant up-regulation and increased nuclear DNA protection play key roles in adaptation to oxidative stress in epithelial cells
2005
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL
2010
Structural and Biochemical Characterization of the Therapeutic Anabaena variabilis Phenylalanine Ammonia Lyase
2008
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology
2002
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
Cancer drug resistance: an evolving paradigm
2013 Standout
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Role of the pro-survival molecule Bfl-1 in melanoma
2014
Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1
2008
The Beclin 1 interactome
2010
BCL-2 family antagonists for cancer therapy
2008
The Bcl2 family: regulators of the cellular life-or-death switch
2002 Standout
Decoding ALS: from genes to mechanism
2016 StandoutNature
Structure-Based Redesign of the Binding Specificity of Anti-Apoptotic Bcl-xL
2012
Apoptosomes: engines for caspase activation
2002
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
The origins and impact of primate segmental duplications
2009
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
2011
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
2011 StandoutNature
The NOD: a signaling module that regulates apoptosis and host defense against pathogens
2001
Mcl‐1–Bim complexes accommodate surprising point mutations via minor structural changes
2010
Autophagy in the Pathogenesis of Disease
2008 Standout
Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis
2011
Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1
2010
Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist
2007
The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
2011
Programmed Anuclear Cell Death Delimits Platelet Life Span
2007
Ways of dying: multiple pathways to apoptosis
2003
Immune Regulation by helminth parasites: cellular and molecular mechanisms
2003 Standout
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Methods in Mammalian Autophagy Research
2010 Standout
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
2007
Mechanism‐Inspired Engineering of Phenylalanine Aminomutase for Enhanced β‐Regioselective Asymmetric Amination of Cinnamates
2011 StandoutNobel
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
2012
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
2015
Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
2013
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim
2001
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
The Hallmarks of Aging
2013 Standout
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Global gene disruption in human cells to assign genes to phenotypes by deep sequencing
2011
BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis
2013
Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1
2010
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood
2003 Standout
The Human Condition—A Molecular Approach
2014 StandoutNobel
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
2009
Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML
2012
The BCL-2 Family Reunion
2010
BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts
2007
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
2009
Mcl‐1; the molecular regulation of protein function
2010
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
2007
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis
2001
From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display
2013
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
2012
Structural insights into the degradation of Mcl-1 induced by BH3 domains
2007
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Two partially homologous adjacent light-inducible maize chloroplast genes encoding polypeptides of the P700 chlorophyll a-protein complex of photosystem I.
1985
Observations on Screening-Based Research and Some Concerning Trends in the Literature
2010
BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
2010
The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity
2010
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
Discovery of Two Cyanobacterial Phenylalanine Ammonia Lyases: Kinetic and Structural Characterization,
2007
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
2016 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors
2011
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
2008
Three-dimensional structure of cyanobacterial photosystem I at 2.5 Å resolution
2001 StandoutNature
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
2012
ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
2013
The Danger Model: A Renewed Sense of Self
2002 StandoutScience
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases
2017
Maximum likelihood inference of protein phylogeny and the origin of chloroplasts
1990
Unusually rapid evolution of Neuroligin-4 in mice
2008 StandoutNobel
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
2010
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
2012
Expression of a gene encoding a novel ferredoxin in the cyanobacterium Synechococcus 6301
1988 StandoutNobel
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
2008
Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease
2011
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad
2009
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Lin Chen being referenced
Cloning and Characterization of a Calcium-binding, Histamine-releasing Protein from Schistosoma mansoni
2002
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
2006
Sequencing human–gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites
2008
Development of Pegylated Forms of Recombinant Rhodosporidium toruloides Phenylalanine Ammonia-Lyase for the Treatment of Classical Phenylketonuria
2005
Light damage induced changes in mouse retinal gene expression
2004
Nucleotide sequence of a multiple-copy gene for the B protein of photosystem II of a cyanobacterium
1984
Demonstration of thein vivointeraction of key cell death regulators by structure-based design of second-site suppressors
2000