Standout Papers
Citation Impact
Citing Papers
Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs
2018 StandoutNobel
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
2017
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
2014
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
2017 Standout
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
2018
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
2016
Poly-ubiquitination in TNFR1-mediated necroptosis
2016
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
2016
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
2015
An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client
2016
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
2013
Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis
2013
A positive feedback loop between RIP 3 and JNK controls non‐alcoholic steatohepatitis
2014
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
2013
Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it
2015
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
2020
RIP3: a molecular switch for necrosis and inflammation
2013
Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse
2016
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture
2020
Necroptosis and its role in inflammation
2015 StandoutNature
Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death
2015
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis
2016
Dying cells actively regulate adaptive immune responses
2017
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
2018
A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development
2013
Chronic inflammation in the etiology of disease across the life span
2019 Standout
Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis
2014
Regulated cell death and inflammation: an auto-amplification loop causes organ failure
2014
Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis
2018
Death by TNF: a road to inflammation
2022
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis
2014
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis
2017
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
2017
Concepts of tissue injury and cell death in inflammation: a historical perspective
2013
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
2013
Activation and regulation of the inflammasomes
2013 Standout
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
Necroptosis in the Pathophysiology of Disease
2019
Live to die another way: modes of programmed cell death and the signals emanating from dying cells
2015
Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death
2015
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis
2016
O-Pair Search with MetaMorpheus for O-glycopeptide characterization
2020 StandoutNobel
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
2015
CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis
2016
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
2014 Nature
Necroptosis and neutrophil-associated disorders
2018
Complete nitrification by Nitrospira bacteria
2015 StandoutNature
Immunogenic cell death in cancer and infectious disease
2016 Standout
The molecular machinery of regulated cell death
2019 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis
2016
Decoding ALS: from genes to mechanism
2016 StandoutNature
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
2016
Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms
2019
Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans
2016
Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis
2016
Metazoan MicroRNAs
2018 Standout
Assignment of Saccharide Identities through Analysis of Oxonium Ion Fragmentation Profiles in LC–MS/MS of Glycopeptides
2014
Differential roles of caspase-1 and caspase-11 in infection and inflammation
2017
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition
2013
The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways
2012
Glutaminolysis and Transferrin Regulate Ferroptosis
2015 Standout
MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation
2017
Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome
2012
The diverse role of RIP kinases in necroptosis and inflammation
2015
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity
2016
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity
2021
Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells
2016
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
2014
Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy
2016
Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma
2017
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
2014
Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation
2013
Necroptosis in development and diseases
2018
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Regulation of tumour necrosis factor signalling: live or let die
2015
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
2014
Regulated necrosis: disease relevance and therapeutic opportunities
2016
Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System
2018
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
2014
Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy
2018 StandoutNobel
Necroptosis in development, inflammation and disease
2016
RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice
2015
Targeting autophagy in cancer
2017 Standout
Developmental checkpoints guarded by regulated necrosis
2016
Mitochondria as multifaceted regulators of cell death
2019 Standout
CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3
2016
The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis
2012
Newly described pattern recognition receptors team up against intracellular pathogens
2013
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3
2015
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
2016 Standout
Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
2013
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
2018
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
A 20-year retrospective review of global aquaculture
2021 StandoutNature
RIPK3 as a potential therapeutic target for Gaucher's disease
2014
Ferroptosis and Necroptosis in the Kidney
2020
A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy
2013
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
2018
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
2017
The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
2015
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
2014
RIPK3-Mediated Necroptosis Regulates Cardiac Allograft Rejection
2014
Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection
2017
Crosstalk between apoptosis, necrosis and autophagy
2013
Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons
2017 StandoutNobel
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation
2018
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI
2016
Exosomes
2019 Standout
Necroptosis: Mechanisms and Relevance to Disease
2016
Control of Life-or-Death Decisions by RIP1 Kinase
2013
Inflammatory outcomes of apoptosis, necrosis and necroptosis
2014
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
2017 Standout
Caspase‐8 functions as a key mediator of inflammation and pro‐IL‐1β processing via both canonical and non‐canonical pathways
2015
Programmed Necrosis in the Cross Talk of Cell Death and Inflammation
2014
Metabolic control of cell death
2014 Science
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential
2007 Standout
Pronecrotic mixed lineage kinase domain‐like protein expression is a prognostic biomarker in patients with early‐stage resected pancreatic adenocarcinoma
2013
Gasdermins and their role in immunity and inflammation
2019
IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection
2018
Structure-Based Design of Functional Amyloid Materials
2014 StandoutNobel
Electron-Based Dissociation Is Needed for O-Glycopeptides Derived from OpeRATOR Proteolysis
2020 StandoutNobel
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium
2017
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
2018
The interplay of IKK , NF ‐κB and RIPK 1 signaling in the regulation of cell death, tissue homeostasis and inflammation
2017
Cytokine Storm
2020 Standout
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
2012
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release
2019
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
2014
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Spermidine in health and disease
2018 StandoutScience
The impacts of suspended mariculture on coastal zones in China and the scope for Integrated Multi-Trophic Aquaculture
2017
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming
2016
MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D
2017
The polycomb repressive complex 2 governs life and death of peripheral T cells
2014
Cell death: a review of the major forms of apoptosis, necrosis and autophagy
2019 Standout
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways
2016
Chaperone-mediated autophagy is involved in the execution of ferroptosis
2019
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis
2019
Mechanism and disease implications of necroptosis and neuronal inflammation
2018
An annexin A1–FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions
2014
Programmed necrosis in inflammation: Toward identification of the effector molecules
2016 Science
Works of Liming Sun being referenced
Potential of the marine sponge Hymeniacidon perleve as a bioremediator of pathogenic bacteria in integrated aquaculture ecosystems
2006
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
2013 Nature
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
Neural detection of gases — carbon dioxide, oxygen — in vertebrates and invertebrates
2009
Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
2014
A Plug Release Mechanism for Membrane Permeation by MLKL
2014
Necrosome core machinery: MLKL
2016
A new kind of cell suicide: mechanisms and functions of programmed necrosis
2014
Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein
2014