Standout Papers
Citation Impact
Citing Papers
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
2007 StandoutNobel
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Mispair-specific Recruitment of the Mlh1-Pms1 Complex Identifies Repair Substrates of the Saccharomyces cerevisiae Msh2-Msh3 Complex
2014
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses
2017
Brawn for Brains: The Role of MEF2 Proteins in the Developing Nervous System
2005
Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans
1995
The p38 MAPK stress pathway as a tumor suppressor or more?
2008
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
1993 Standout
EXO1 Plays a Role in Generating Type I and Type II Survivors in Budding Yeast
2004
Visualization of Eukaryotic DNA Mismatch Repair Reveals Distinct Recognition and Repair Intermediates
2011
Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo
1999
Signal integration by JNK and p38 MAPK pathways in cancer development
2009 Standout
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Feedback control of the protein kinase TAK1 by SAPK2a/p38
2003
Oxidative stress and gene regulation
2000
Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket
1998
Genetic analysis of resistance to viral infection
2007 StandoutNobel
The pathways to tumor suppression via route p38
2007
Post-translational control of the MEF2A transcriptional regulatory protein
1999
p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis
2000
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
2007
Mechanism of p38 MAP kinase activation in vivo
2003
Cell cycle regulation by p38 MAP kinases
2001
The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
2008
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Regulation of skeletal muscle gene expression by p38 MAP kinases
2005
Sequential Activation of Signaling Pathways during Innate Immune Responses in Drosophila
2002
β2-Adrenergic Receptor-induced p38 MAPK Activation Is Mediated by Protein Kinase A Rather than by Gi or Gβγ in Adult Mouse Cardiomyocytes
2000 StandoutNobel
Preferential Binding of Grb2 or Phosphatidylinositol 3-Kinase to the Met Receptor Has Opposite Effects on HGF-Induced Myoblast Proliferation
2002
A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation
2004
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Mismatch repair proteins: key regulators of genetic recombination
2004
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis
2009
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
RNA interference against viruses: strike and counterstrike
2007
The p38 signal transduction pathway Activation and function
2000
Mismatch repair and cancer susceptibility
1994
MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation
1999
Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
2009
p38MAPK in the Senescence of Human and Murine Fibroblasts
2010
Distinct carboxy‐termini confer divergent characteristics to the mitogen‐activated protein kinase p38α and its splice isoform Mxi2
2000
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase
1999
MEK Kinase 3 Directly Activates MKK6 and MKK7, Specific Activators of the p38 and c-Jun NH2-terminal Kinases
1999
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice
1999
Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone Deacetylases
2000
MyoD and the transcriptional control of myogenesis
2005
p38 MAP-Kinases pathway regulation, function and role in human diseases
2007
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Post‐transcriptional regulation of gene expression by mitogen‐activated protein kinase p38
2003
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Biochemical Characterization of the Interaction between the Saccharomyces cerevisiae MSH2-MSH6 Complex and Mispaired Bases in DNA
1999
The essence of senescence: Figure 1.
2010 Standout
The immune response of Drosophila
2003 StandoutNatureNobel
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
MAP kinase pathways
1999
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
1998
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
2003
Oncogene-induced senescence: the bright and dark side of the response
2010
Phosphorylation Motifs Regulating the Stability and Function of Myocyte Enhancer Factor 2A
2003
Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila
2009
Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38α in abrogating myoblast proliferation
2007
Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
2000
p38α: A Suppressor of Cell Proliferation and Tumorigenesis
2007
p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation
2007
Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1
2002
Requirement for p38α in Erythropoietin Expression
2000
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
New Insights into the Control of MAP Kinase Pathways
1999
p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
2007
Mekk3 is essential for early embryonic cardiovascular development
2000
Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications
2000
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
1995 StandoutScienceNobel
Promoter-Specific Regulation of MyoD Binding and Signal Transduction Cooperate to Pattern Gene Expression
2002
The Evolution of the MAP Kinase Pathways: Coduplication of Interacting Proteins Leads to New Signaling Cascades
1999
Meiotic Pachytene Arrest in MLH1-Deficient Mice
1996
Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases
1999
p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci
2004
Antiviral Immunity Directed by Small RNAs
2007
Senescence in tumours: evidence from mice and humans
2009
Involvement of p38α Mitogen-activated Protein Kinase in Lung Metastasis of Tumor Cells
2006
Cellular senescence: from physiology to pathology
2014 Standout
Mechanism of Induction and Suppression of Antiviral Immunity Directed by Virus-Derived Small RNAs in Drosophila
2008
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest
2000
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain‐induced cardiovascular differentiation
2006
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells
2000
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells
1995 StandoutScienceNobel
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
The evolution of RNAi as a defence against viruses and transposable elements
2008
p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps
2000
p38 Mitogen‐Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis
2006
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches.
1994
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair
2001 StandoutNobel
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
1996 StandoutNobel
GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells
1995 Science
EXO1 Plays a Role in Generating Type I and Type II Survivors in Budding Yeast
2004
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila
2010 StandoutNobel
Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy
2001
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.
1996
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene
1994
Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors
1999
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
2002 StandoutScience
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
1999
Akt2, a Novel Functional Link between p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Myogenesis
2004
p38-γ–dependent gene silencing restricts entry into the myogenic differentiation program
2009
Deficiency of the Stress Kinase P38α Results in Embryonic Lethality
2000
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
2000
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Single-Molecule FRET TACKLE Reveals Highly Dynamic Mismatched DNA−MutS Complexes
2010
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
1995 StandoutNobel
Satellite Cells and the Muscle Stem Cell Niche
2013 Standout
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Elimination of Protein Kinase MK5/PRAK Activity by Targeted Homologous Recombination
2003
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Map kinase signaling pathways and hematologic malignancies
2003
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase
2011
A Network of Mitogen-Activated Protein Kinases Links G Protein-Coupled Receptors to the c-jun Promoter: a Role for c-Jun NH2-Terminal Kinase, p38s, and Extracellular Signal-Regulated Kinase 5
1999
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
Mismatch Repair, Genetic Stability, and Cancer
1994 StandoutScienceNobel
Biochemistry and genetics of eukaryotic mismatch repair.
1996
DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair
1997 StandoutNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.
1994
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Liguo New being referenced
cDNA Cloning ofrasp-1,a Novel Gene Encoding a Plasma Protein Associated with Liver Regeneration
1996
Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase
1998
Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ
1997
The p38 MAP Kinase Pathway and Its Biological Function
1998
PRAK, a novel protein kinase regulated by the p38 MAP kinase
1998
PRAK Is Essential for ras-Induced Senescence and Tumor Suppression
2007
The yeast gene MSH3 defines a new class of eukaryotic MutS homologues
1993
Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression
2007 StandoutNobel
Urokinase Plasminogen Activator/Urokinase-specific Surface Receptor Expression and Matrix Invasion by Breast Cancer Cells Requires Constitutive p38α Mitogen-activated Protein Kinase Activity
2000
Cloning and Characterization of RLPK, a Novel RSK-related Protein Kinase
1999
Phosphorylation of eIF-4E on Ser 209 in Response to Mitogenic and Inflammatory Stimuli Is Faithfully Detected by Specific Antibodies
2000
Mitotic Crossovers between Diverged Sequences Are Regulated by Mismatch Repair Proteins in Saccharomyces cerevisiae
1996
Gene suppression by tristetraprolin and release by the p38 pathway
2001
Regulation of the MEF2 Family of Transcription Factors by p38
1999
MAPKK-Independent Activation of p38α Mediated by TAB1-Dependent Autophosphorylation of p38α
2002 Science
Regulation of PRAK Subcellular Location by p38 MAP Kinases
2003