Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells
2019 StandoutNobel
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Lipid Rafts As a Membrane-Organizing Principle
2009 StandoutScience
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
2013
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
2020 StandoutNobel
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
2013 Science
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans
2008 Science
Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors
2011
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
2013
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
2013
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Accurate classification of BRCA1 variants with saturation genome editing
2018 Nature
Emerging tools for bioluminescence imaging
2021
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
2016 Standout
Species‐specific detection of the antiviral small‐molecule compound CMA by STING
2013
Three-dimensional structure of human γ-secretase
2014 Nature
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Pyrin Activates the ASC Pyroptosome in Response to Engagement by Autoinflammatory PSTPIP1 Mutants
2007
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
A Naturally Occurring Repeat Protein with High Internal Sequence Identity Defines a New Class of TPR-like Proteins
2015
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
2004
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
2009 StandoutNature
Structure and function of haemoglobins
2017
Maintenance of the DNA-Damage Checkpoint Requires DNA-Damage-Induced Mediator Protein Oligomerization
2009
Mitochondria: In Sickness and in Health
2012 Standout
Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
2013
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
2014
The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities
2018
The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
2014
MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
2005
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
2012
Steric trapping reveals a cooperativity network in the intramembrane protease GlpG
2016
A Glimpse of Structural Biology through X-Ray Crystallography
2014
Immune Sensing of DNA
2013
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
2013
Inactivation of HAUSP in vivo modulates p53 function
2009
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Membrane lipids: where they are and how they behave
2008 Standout
Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom
2012
Mapping the energy landscape for second-stage folding of a single membrane protein
2015
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
2009
Origin and physiological roles of inflammation
2008 StandoutNature
Histone Modifications and Chromatin Remodeling during Bacterial Infections
2008
How to build a pathogen detector: structural basis of NB-LRR function
2012
The Inflammasomes
2010 Standout
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
2014
Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation
2007
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Life in the balance: how BH3-only proteins induce apoptosis
2005
Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1
2007
Engulfment of apoptotic cells: signals for a good meal
2007
Resistance proteins: molecular switches of plant defence
2006
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
Structure and function of γ-secretase
2008
The plant immune system
2006 StandoutNature
Inflammasomes in health and disease
2012 StandoutNature
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
Pivoting the Plant Immune System from Dissection to Deployment
2013 StandoutScience
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
2018 StandoutNobel
The BCL-2–like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2– and EAT-3/Opa1–dependent mitochondrial fusion
2009
Repurposing Peptide Nanomaterials as Synthetic Biomolecular Condensates in Bacteria
2022
DOG-1 Is the Caenorhabditis elegans BRIP1/FANCJ Homologue and Functions in Interstrand Cross-Link Repair
2007
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors
2019
De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity
2024 StandoutNobel
EVOLUTIONARY RELATIONSHIPS AND STRUCTURAL MECHANISMS OF AAA+ PROTEINS
2006
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Self-Assembled Crystalline Bundles in Soluble Metal–Organic Nanotubes
2023 StandoutNobel
C−C Bond-Forming Lyases in Organic Synthesis
2011
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
2013 Standout
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
2013
Applications of bioluminescence in biotechnology and beyond
2021
The Distribution and Function of Phosphatidylserine in Cellular Membranes
2010
Genetic and Biochemical Analysis of Non-Vesicular Lipid Traffic
2009
Metal-organic nanotubes: Designs, structures and functions
2019
Reshaping de Novo Protein Switches into Bioresponsive Materials for Biomarker, Toxin, and Viral Detection
2022 StandoutNobel
Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release
2017 StandoutNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Works of Lichuan Gu being referenced
Phase transfer catalyst supported, room-temperature biphasic synthesis: a facile approach to the synthesis of coordination polymers
2012
Structure of an acidic phospholipase A2from the venom ofDeinagkistrodon acutus
2001
Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility
2012
Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4
2004
Molecular Mechanism of AHSP-Mediated Stabilization of α-Hemoglobin
2004
Structural basis for the catalytic mechanism of phosphothreonine lyase
2007
Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway
2006
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
2012
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
2006
Structure of the CED-4–CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
2005 Nature
Structural Basis for Activation and Inhibition of the Secreted Chlamydia Protease CPAF
2008
An efficient method for N-acetyl-d-neuraminic acid production using coupled bacterial cells with a safe temperature-induced system
2009
Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide
2004
C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1
2007
Structure of oxidized α-haemoglobin bound to AHSP reveals a protective mechanism for haem
2005 Nature
cybLuc: An Effective Aminoluciferin Derivative for Deep Bioluminescence Imaging
2017
T5 exonuclease-dependent assembly offers a low-cost method for efficient cloning and site-directed mutagenesis
2018