Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Oxidative Stress
2017 Standout
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
2009
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α
2007
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Genetic evidence for a tumor suppressor role of HIF-2α
2005
Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities
2009
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
2006
Acute postnatal ablation of Hif-2 α results in anemia
2007
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells
2004
Hallmarks of Cancer: The Next Generation
2011 Standout
Regulation of hypoxia‐inducible factor‐α isoforms and redox state by carotid body neural activity in rats
2014 StandoutNobel
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia
2007
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Cardiopulmonary function in two human disorders of the hypoxia‐inducible factor (HIF) pathway: von Hippel‐Lindau disease and HIF‐2α gain‐of‐function mutation
2011 StandoutNobel
Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis
2009
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea
2015 StandoutNobel
Biology of hypoxia-inducible factor-2α in development and disease
2008
Molecular chaperones and proteostasis regulation during redox imbalance
2014
Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells
2011
Age-related changes of myocardial ATP supply and demand mechanisms
2013
Responses to reductive stress in the cardiovascular system
2016
Atomic model of the type III secretion system needle
2012 StandoutNatureNobel
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1
2007 StandoutNobel
HIF-1: upstream and downstream of cancer metabolism
2009 StandoutNobel
Selective targeting of an antioxidant to mitochondria
1999
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
2002
Protein carbonylation, cellular dysfunction, and disease progression
2006
Oxidative stress and gene regulation
2000
Roles of Hypoxia-Inducible Factor-1α (Hif-1α) Versus Hif-2α in the Survival of Hepatocellular Tumor Spheroids
2010
Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species
1999
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by Hsp27 expression
2004
Class B Scavenger Receptors CD36 and SR-BI Are Receptors for Hypochlorite-modified Low Density Lipoprotein
2003
Telomere states and cell fates
2000 StandoutNatureNobel
Mitochondria and Cancer: Warburg Addressed
2005
Involvement of Hypoxia-Inducible Factor 1 in Pulmonary Pathophysiology
2005 StandoutNobel
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
2004
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
The essence of senescence: Figure 1.
2010 Standout
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
1997
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Impact of Oxidative Stress on the Heart and Vasculature
2017
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Genetic analysis of ageing: role of oxidative damage and environmental stresses
1996
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
2007
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
2007
Role of oxidative carbonylation in protein quality control and senescence
2005
Chromatin as an oxygen sensor and active player in the hypoxia response
2011
Free radicals and senescence
2008
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers
2010
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
2013 StandoutNobel
Mitochondria and cancer
2012 Standout
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
2009
Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase
2006
Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage
2019
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Oxygen homeostasis
2009 StandoutNobel
Cellular senescence: from physiology to pathology
2014 Standout
Free radicals, reactive oxygen species, oxidative stress and its classification
2014
Feedback between p21 and reactive oxygen production is necessary for cell senescence
2010
Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication
1998
Life with Oxygen
2007 StandoutScienceNobel
Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein
2000
Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation
1999
The Free Radical Theory of Aging Matures
1998 Standout
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
2009 Science
Quality Control by DNA Repair
1999 StandoutScienceNobel
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
2005
Biochemistry and pathology of radical-mediated protein oxidation
1997
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
2009
Ku is associated with the telomere in mammals
1999 StandoutNobel
Hypoxia-induced methylation of a pontin chromatin remodeling factor
2011
Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
1998
Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
2018
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
2014 Standout
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Redox Signaling in Cardiac Physiology and Pathology
2012
Essential Role of Developmentally Activated Hypoxia-Inducible Factor 1α for Cardiac Morphogenesis and Function
2008
DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine
1998
Redox Proteomics: Chemical Principles, Methodological Approaches and Biological/Biomedical Promises
2012
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
2013 StandoutNobel
Oxidation of LDL by Myeloperoxidase and Reactive Nitrogen Species
2000
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
2004 StandoutNobel
Mammalian Tissue Oxygen Levels Modulate Iron-Regulatory Protein Activities in Vivo
2004 Science
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Bioinorganic Chemistry of Alzheimer’s Disease
2012
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
The signals and pathways activating cellular senescence
2004
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
2015 StandoutNobel
Erythrocytosis: the HIF pathway in control
2013
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Oxidative Stress Signaling to Chromatin in Health and Disease
2016
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
2007 StandoutNobel
A cell nanoinjector based on carbon nanotubes
2007 StandoutNobel
Does vitamin C act as a pro‐oxidant under physiological conditions?
1999
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
Erythropoietin: Powerful protection of ischemic and post-ischemic brain
2014
Longevity, Genes, and Aging
1996 Science
DNA damage is able to induce senescence in tumor cells in vitro and in vivo.
2002
Aconitases: Non-redox Iron–Sulfur Proteins Sensitive to Reactive Species
2019
Works of Liang‐Jun Yan being referenced
Comparison between copper-mediated and hypochlorite-mediated modifications of human low density lipoproteins evaluated by protein carbonyl formation
1997
Hypoxia-inducible Factor 2α Regulates Expression of the Mitochondrial Aconitase Chaperone Protein Frataxin
2007
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice
2003
Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells
2006
Gel Electrophoretic Quantitation of Protein Carbonyls Derivatized with Tritiated Sodium Borohydride
1998
Urine Sample-Derived Cerebral Organoids Suitable for Studying Neurodevelopment and Pharmacological Responses
2020
Neuroprotective Actions of Methylene Blue and Its Derivatives
2012
The Lipoic Acid Analogue 1,2-Diselenolane-3-pentanoic Acid Protects Human Low Density Lipoprotein against Oxidative Modification Mediated by Copper Ion
1997
Efficacy of Hypochlorous Acid Scavengers in the Prevention of Protein Carbonyl Formation
1996
Effects of aging and hyperoxia on oxidative damage to cytochrome c in the housefly, Musca domestica
2000
Mass spectrometry‐based survey of age‐associated protein carbonylation in rat brain mitochondria
2007
Positive oxidative stress in aging and aging-related disease tolerance
2014
Chemical probes for analysis of carbonylated proteins: A review
2010
Human αB-Crystallin Mutation Causes Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy in Mice
2007
Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage
2002
Protein Redox Modification as a Cellular Defense Mechanism against Tissue Ischemic Injury
2014
Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress
2014
Oxidative damage during aging targets mitochondrial aconitase
1997
Protein Oxidative Modifications: Beneficial Roles in Disease and Health.
2013
Oxidative DNA damage and senescence of human diploid fibroblast cells.
1995
Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
1998