Citation Impact
Citing Papers
Oxidative Stress
2017 Standout
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress–Induced DPP3–KEAP1 Interaction
2017
Sulforaphane treatment of autism spectrum disorder (ASD)
2014
Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
2005 StandoutNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Transcriptional Regulation by Nrf2
2017 Standout
Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling
2015
The multifaceted role of Nrf2 in mitochondrial function
2016
Hydrogen peroxide sensing, signaling and regulation of transcription factors
2014
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
2016
Kidney epithelium specific deletion of kelch-like ECH-associated protein 1 (Keap1) causes hydronephrosis in mice
2016
Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy
2017
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
2017
An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
2016
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
2017
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression
2017 Standout
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice
2017
IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model
2017
Role of Nrf2 and Autophagy in Acute Lung Injury
2016
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
Microbial tryptophan catabolites in health and disease
2018 Standout
Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP
2015
Autophagy and the Integrated Stress Response
2010 Standout
Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models
2018
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
2009 Standout
NRF2 immunolocalization in human breast cancer patients as a prognostic factor
2013
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction with improved binding and cellular activity
2013
Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2
2015
Nrf2 regulates ROS production by mitochondria and NADPH oxidase
2014
Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405
2015
NRF2 and the Hallmarks of Cancer
2018
The Keap1–Nrf2 system and diabetes mellitus
2014
Cardiac autophagy is a maladaptive response to hemodynamic stress
2007 Standout
Regulation of stress signaling pathways by nitro-fatty acids
2018
C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
2018
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
2014
Immunogenic cell death in cancer and infectious disease
2016 Standout
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
2016 Standout
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis (cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action
2015
NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology
2017
The KEAP1–NRF2 System in Cancer
2017
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
2015
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
2013
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Decoding ALS: from genes to mechanism
2016 StandoutNature
Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency
2017
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation
2016
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II–induced contraction of glomerular mesangial cells
2012
MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)
2013
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
2018 Standout
Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney
2012
Mechanisms and functions of Nrf2 signaling in Drosophila
2015
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
2015
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Redox stress and signaling during vertebrate embryonic development: Regulation and responses
2017
The Keap1–Nrf2 protein–protein interaction: A suitable target for small molecules
2017
Oxidative Stress in Cancer
2020 Standout
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
2014 Standout
Molecular basis of the Keap1–Nrf2 system
2015
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity
2011
Targeting ferroptosis as a vulnerability in cancer
2022 Standout
Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity
2017
Keap1 as the redox sensor of the antioxidant response
2016
Autophagy in cell death: an innocent convict?
2005 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents
2015
NRF2/Long Noncoding RNA ROR Signaling Regulates Mammary Stem Cell Expansion and Protects against Estrogen Genotoxicity
2014
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
2017
The Hallmarks of Aging
2013 Standout
Discovery and resupply of pharmacologically active plant-derived natural products: A review
2015 Standout
Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction
2013
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress
2017
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
2016 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
The amyloid state and its association with protein misfolding diseases
2014 Standout
Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding
2016
Thermodynamic profiling of inhibitors of Nrf2:Keap1 interactions
2015
Regulation of stress signaling pathways by protein lipoxidation
2019
Nrf2 activation improves experimental rheumatoid arthritis
2023 StandoutNobel
An Overview of the Advantages of KEAP1-NRF2 System Activation During Inflammatory Disease Treatment
2017
Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response
2014
TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System
2015
Principles in Redox Signaling: From Chemistry to Functional Significance
2012
NFE2L2/NRF2 Activity Is Linked to Mitochondria and AMP-Activated Protein Kinase Signaling in Cancers Through miR-181c/Mitochondria-Encoded Cytochrome c Oxidase Regulation
2017
Nrf2, the Master Regulator of Anti-Oxidative Responses
2017
Nrf2 affects the efficiency of mitochondrial fatty acid oxidation
2013
Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism
2016
The Cyclopentenone Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes
2015
Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time
2017
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis
2012
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
2015
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP
2016
Identification of Non-Electrophilic Nrf2 Activators from Approved Drugs
2017
Fluorescence Lifetime Measurements and Biological Imaging
2010 Standout
Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle‐age period
2016
IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways
2018
Recent applications of click chemistry in drug discovery
2019
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1
2013
Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function
2016
Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria
2015
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy
2012
mTOR: a pharmacologic target for autophagy regulation
2015 Standout
A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity
2014
Membrane Morphology Is Actively Transformed by Covalent Binding of the Protein Atg8 to PE-Lipids
2014 StandoutNobel
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy
2018
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases
2018
Redox Signaling by Reactive Electrophiles and Oxidants
2018
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)
2017
Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice
2017 StandoutNobel
Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions
2016
Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients
2014
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Liam Baird being referenced
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
2015
NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth
2016
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
2019
Diffusion dynamics of the Keap1–Cullin3 interaction in single live cells
2013
The cytoprotective role of the Keap1–Nrf2 pathway
2011
Monitoring Keap1–Nrf2 interactions in single live cells
2014
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
2017
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
2013
Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells
2016
Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction
2015
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
2013
Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes
2014
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
2020
A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways
2016
The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics
2015
Discovery of an NRF 1‐specific inducer from a large‐scale chemical library using a direct NRF 1‐protein monitoring system
2015