Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
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2006
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription
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Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27
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2009
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The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins
2004
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2008
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
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2011
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2009
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2005
The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans
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Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
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Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
2006
Notch-GATA synergy promotes endoderm-specific expression of ref-1 in C. elegans
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The MES-2/MES-3/MES-6 Complex and Regulation of Histone H3 Methylation in C. elegans
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Signals and Combinatorial Functions of Histone Modifications
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PLU-1 Is an H3K4 Demethylase Involved in Transcriptional Repression and Breast Cancer Cell Proliferation
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The molecular hallmarks of epigenetic control
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Genome-wide analysis of Polycomb targets in Drosophila melanogaster
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SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex
2004
Elements of cancer immunity and the cancer–immune set point
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2008
Specificity and mechanism of the histone methyltransferase Pr-Set7
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Determinants and dynamics of genome accessibility
2011
Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes
2004
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
2011 Nature
Target Selectivity of Vertebrate Notch Proteins
2005
Epigenetic regulation of theINK4b-ARF-INK4alocus
2010
Polycomb Repressive Complexes Restrain the Expression of Lineage-Specific Regulators in Embryonic Stem Cells
2006
Identification and Characterization of a Novel Human Histone H3 Lysine 36-specific Methyltransferase
2005
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Transcriptional Silencing by Polycomb-Group Proteins
2014
Deconstruction of the SS18-SSX Fusion Oncoprotein Complex: Insights into Disease Etiology and Therapeutics
2012 Nobel
Polycomb group complexes – many combinations, many functions
2009
Non-histone protein methylation as a regulator of cellular signalling and function
2014
Nas transgenic mouse line allows visualization of Notch pathway activity in vivo
2006
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
2004
Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Genome imprinting regulated by the mouse Polycomb group protein Eed
2003
Molecular biology of the Ets family of transcription factors
2003
Chromatin Modifications and Their Function
2007 Standout
A model for transmission of the H3K27me3 epigenetic mark
2008
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Regulation of Set9-Mediated H4K20 Methylation by a PWWP Domain Protein
2009
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9
2005
PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis
2010
Histone methylation in transcriptional control
2002
Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells
2009
Polycomb silencers control cell fate, development and cancer
2006
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
2006
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells
2013
Role of Bmi-1 and Ring1A in H2A Ubiquitylation and Hox Gene Silencing
2005
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
2010
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
2004
Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination
2010
Histone methylation: a dynamic mark in health, disease and inheritance
2012 Standout
Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes
2011
Different Ezh2-Containing Complexes Target Methylation of Histone H1 or Nucleosomal Histone H3
2004
Targeted Recruitment of Set1 Histone Methylase by Elongating Pol II Provides a Localized Mark and Memory of Recent Transcriptional Activity
2003
Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression
2010
Polycomb Group Proteins Ring1A/B Link Ubiquitylation of Histone H2A to Heritable Gene Silencing and X Inactivation
2004
The REF-1 Family of bHLH Transcription Factors Pattern C. elegans Embryos through Notch-Dependent and Notch-Independent Pathways
2005
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3
2006
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association
2002
Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms
2008
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex
2006
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Methylation of Histone H4 Lysine 20 Controls Recruitment of Crb2 to Sites of DNA Damage
2004
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
2011 Nature
Jarid2 and PRC2, partners in regulating gene expression
2010
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force
2017
Ubiquitination of Histone H2B by Rad6 Is Required for Efficient Dot1-mediated Methylation of Histone H3 Lysine 79
2002
Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
2016
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
2007
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Characterization of Drosophila melanogaster JmjC+N histone demethylases
2008
Analyzing real-time PCR data by the comparative CT method
2008 Standout
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
2007
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
2010
Role of histone H2A ubiquitination in Polycomb silencing
2004 Nature
Regulation of MLL1 H3K4 methyltransferase activity by its core components
2006
Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas
2010
The key to development: interpreting the histone code?
2005
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
2002
Role of Protein Methylation in Regulation of Transcription
2005
Regulation of heterochromatin by histone methylation and small RNAs
2004
The Transcriptional and Epigenomic Foundations of Ground State Pluripotency
2012
A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation
2004
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
2010
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
2013 Standout
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis
2005
Myc-binding-site recognition in the human genome is determined by chromatin context
2006
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
2002
Role of the polycomb protein EED in the propagation of repressive histone marks
2009 Nature
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
Notch signalling: a simple pathway becomes complex
2006 Standout
Epigenetic regulation of stem cell fate
2008
Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors
2008
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
2004
A Switch in Mitotic Histone H4 Lysine 20 Methylation Status Is Linked to M Phase Defects upon Loss of HCF-1
2004
Immunity, Inflammation, and Cancer
2010 Standout
Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer
2008
AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2
2009
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities
2006
A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain
2009
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
2010 Nature
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
2003
The diverse functions of histone lysine methylation
2005 Standout
Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation
2010
Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling
2010
A MicroRNA Imparts Robustness against Environmental Fluctuation during Development
2009
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3
2004
Histone and chromatin cross-talk
2003
Molecular recognition of histone H3 by the WD40 protein WDR5
2006
mAM Facilitates Conversion by ESET of Dimethyl to Trimethyl Lysine 9 of Histone H3 to Cause Transcriptional Repression
2003
The emerging field of dynamic lysine methylation of non-histone proteins
2008
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
Polycomb Group Protein Ezh2 Controls Actin Polymerization and Cell Signaling
2005
Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases
2012
A histone H3 lysine 27 demethylase regulates animal posterior development
2007 Nature
Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro
2009
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
2003
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27
2004
2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association
2010
Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy
2018 StandoutNobel
Polycomb complexes repress developmental regulators in murine embryonic stem cells
2006 StandoutNature
Signaling Network Model of Chromatin
2002
Polycomb complexes and silencing mechanisms
2004
The Polycomb group protein EZH2 directly controls DNA methylation
2005 StandoutNature
Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2
2010
The H3K27 demethylase UTX‐1 regulates C. elegans lifespan in a germline‐independent, insulin‐dependent manner
2011
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers
2008
Stem Cells and Cancer
2004 Standout
A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers
2004
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
2007
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
2004
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
2004
Polycomb Complexes and the Propagation of the Methylation Mark at the Drosophila Ubx Gene
2006
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
2002
Hierarchical Recruitment of Polycomb Group Silencing Complexes
2004
Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
2003 Nature
The Hallmarks of Aging
2013 Standout
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Epigenetic modifications in pluripotent and differentiated cells
2010
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
Preferential Dimethylation of Histone H4 Lysine 20 by Suv4-20
2008
The many faces of histone lysine methylation
2002
Topological domains in mammalian genomes identified by analysis of chromatin interactions
2012 StandoutNature
MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters
2002
Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain
2002
Ring1b-mediated H2A Ubiquitination Associates with Inactive X Chromosomes and Is Involved in Initiation of X Inactivation
2004
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex
2004
EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency
2008
Comprehensive Catalog of Currently Documented Histone Modifications
2015
Low levels of miR‐92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma
2007
Suz12 binds to silenced regions of the genome in a cell-type-specific manner
2006
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
Polycomb complexes act redundantly to repress genomic repeats and genes
2010
Establishment of Histone H3 Methylation on the Inactive X Chromosome Requires Transient Recruitment of Eed-Enx1 Polycomb Group Complexes
2003
The Murine Polycomb Group Protein Eed Is Required for Global Histone H3 Lysine-27 Methylation
2005
Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome
2009
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination
2007 Science
Division of labor in Polycomb group repression
2004
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
2003
Controlling histone methylation via trans-histone pathways
2008
Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice
2009
MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in theC. elegansgerm line
2006
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair
2006
Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor
2008
Reactivation of the Paternal X Chromosome in Early Mouse Embryos
2004 StandoutScienceNobel
Chromatin Modifications by Methylation and Ubiquitination: Implications in the Regulation of Gene Expression
2006
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
2010
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity
2008
Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo
2008
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
2012 StandoutNobel
Histone Code Modifications on Pluripotential Nuclei of Reprogrammed Somatic Cells
2004
Recruitment ofDrosophilaPolycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae
2008
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
2007
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
2003
Epigenetic aspects of differentiation
2004
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
2012 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins
2004
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
2013 StandoutNobel
PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator
2005 StandoutScienceNobel
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2
2008
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
2012 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Inactivation of a histone methyltransferase by mutations in human cancers.
2003
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance
2009
An epigenetic road map for histone lysine methylation
2003
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Mechanisms of Polycomb gene silencing: knowns and unknowns
2009
Role of Histone H3 Lysine 27 Methylation in X Inactivation
2003 Science
NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression
2011
Works of Li Xia being referenced
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
2002 StandoutScience
A DNA Transcription Code for Cell-Specific Gene Activation by Notch Signaling
2005
Differential Regulation of Transcription through Distinct Suppressor of Hairless DNA Binding Site Architectures during Notch Signaling in Proneural Clusters
2010
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor
2002
Purification and Functional Characterization of SET8, a Nucleosomal Histone H4-Lysine 20-Specific Methyltransferase
2002
Identification and Functional Characterization of the p66/p68 Components of the MeCP1 Complex
2002