Standout Papers
Citation Impact
Citing Papers
5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
2009
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes
2008
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Characterization of a canine homolog of hepatitis C virus
2011 StandoutNobel
Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
2009
Functional Genomic Analysis of RNA Interference in C. elegans
2005 StandoutScienceNobel
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans
2006 StandoutScienceNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Cutting Edge: Polyinosinic:Polycytidylic Acid Boosts the Generation of Memory CD8 T Cells through Melanoma Differentiation-Associated Protein 5 Expressed in Stromal Cells
2010
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Nucleotide sequence homology requirements of HIV-1-specific short hairpin RNA
2003
RNA interference is an antiviral defence mechanism in Caenorhabditis elegans
2005 Nature
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
MicroRNAs
2004 Standout
Interfering with hepatitis C virus RNA replication
2004 StandoutNobel
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
2009
Type I Interferons in Host Defense
2006
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
2007 StandoutNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Genetic analysis of resistance to viral infection
2007 StandoutNobel
Down-regulation of viral replication by adenoviral-mediated expression of siRNA against cellular cofactors for hepatitis C virus
2004
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster
2006
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
Pattern recognition of viral nucleic acids by RIG-I-like helicases
2010
ATP-sensitive potassium channels mediate survival during infection in mammals and insects
2007 StandoutNobel
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
RNA interference against viruses: strike and counterstrike
2007
RNAi Targeting of West Nile Virus in Mosquito Midguts Promotes Virus Diversification
2009
Stable suppression of tumorigenicity by virus-mediated RNA interference
2002
RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection
2010
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques
2009 StandoutNobel
Immune Signaling by RIG-I-like Receptors
2011
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Killing the messenger: short RNAs that silence gene expression
2003
Interferons induce an antiviral state in human pancreatic islet cells
2007
Gene silencing in mammals by small interfering RNAs
2002
Heat Shock Protein gp96 Is a Master Chaperone for Toll-like Receptors and Is Important in the Innate Function of Macrophages
2007
Activation of the interferon system by short-interfering RNAs
2003
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction
2016
Replication in Cells of Hematopoietic Origin Is Necessary for Dengue Virus Dissemination
2012
Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5
2009
Is RNA interference involved in intrinsic antiviral immunity in mammals?
2006
Mechanisms of gene silencing by double-stranded RNA
2004 StandoutNature
The functions of animal microRNAs
2004 StandoutNatureNobel
Cellular RNA-Dependent RNA Polymerase Involved in Posttranscriptional Gene Silencing Has Two Distinct Activity Modes
2002
Cytosolic 5′-Triphosphate Ended Viral Leader Transcript of Measles Virus as Activator of the RIG I-Mediated Interferon Response
2007
Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses
2006
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development
2015
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
2003
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
2010 StandoutNobel
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
2009 StandoutNobel
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Allele-specific silencing of dominant disease genes
2003
Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus
2014 StandoutNobel
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
2011
Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro
2012 StandoutNobel
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
2008
Viral evasion and subversion of pattern-recognition receptor signalling
2008
Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis
2019
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
2011 StandoutNobel
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses
2007
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila
2010 StandoutNobel
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Human Immunodeficiency Virus Type 1 Escape from RNA Interference
2003
Genetic diversity and evolution of hepatitis C virus – 15 years on
2004
Interference of hepatitis C virus RNA replication by short interfering RNAs
2003
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
2015 Science
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm
2019
Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1
2007
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
2002 StandoutNobel
Short Interfering RNA-Mediated Inhibition of Herpes Simplex Virus Type 1 Gene Expression and Function during Infection of Human Keratinocytes
2004 StandoutNobel
RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster
2006
RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells
2003
5'-Triphosphate RNA Is the Ligand for RIG-I
2006 StandoutScience
Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8 + T cells
2010 StandoutNobel
TLR3 Is Essential for the Induction of Protective Immunity against Punta Toro Virus Infection by the Double-Stranded RNA (dsRNA), Poly(I:C12U), but not Poly(I:C): Differential Recognition of Synthetic dsRNA Molecules
2007
Progress toward the therapy of hepatitis with RNAi† ‡
2005
Susceptibility of Human Hepatitis Delta Virus RNAs to Small Interfering RNA Action
2003
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates
2006 StandoutScience
TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection
2019
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
2003 StandoutNobel
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Leonid Gitlin being referenced
Poliovirus Escape from RNA Interference: Short Interfering RNA-Target Recognition and Implications for Therapeutic Approaches
2004
Short interfering RNA confers intracellular antiviral immunity in human cells
2002 Nature
MDA-5 Recognition of a Murine Norovirus
2008
MDA5 Participates in the Detection of Paramyxovirus Infection and Is Essential for the Early Activation of Dendritic Cells in Response to Sendai Virus Defective Interfering Particles
2008
Nucleic Acid-Based Immune System: the Antiviral Potential of Mammalian RNA Silencing
2003
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel